Výsledky vyhledávání - "Rami N, Hannoush"

Akademický článek

Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region

Autor: Yanjie Li, Yuehua Wei, Mark Ultsch, Wei Li, Wanjian Tang, Benjamin Tombling, Xinxin Gao, Yoana Dimitrova, Christian Gampe, Jakob Fuhrmann, Yingnan Zhang, Rami N. Hannoush, Daniel Kirchhofer

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Cystine-knot peptides (CKPs) are naturally occurring peptides that exhibit exceptional chemical and proteolytic stability. We leveraged the CKP carboxypeptidase A1 inhibitor as a scaffold to construct phage-displayed CKP libraries and subseq

Externí odkaz: https://doaj.org/article/11f73166b3ab4e1eb0a08d5e402e1864

Zobrazit plný text záznamu

Akademický článek

Disulfide-constrained peptide scaffolds enable a robust peptide-therapeutic discovery platform.

Autor: Lijuan Zhou, Fei Cai, Yanjie Li, Xinxin Gao, Yuehua Wei, Anna Fedorova, Daniel Kirchhofer, Rami N Hannoush, Yingnan Zhang

Publikováno v: PLoS ONE, Vol 19, Iss 3, p e0300135 (2024)

Peptides present an alternative modality to immunoglobulin domains or small molecules for developing therapeutics to either agonize or antagonize cellular pathways associated with diseases. However, peptides often suffer from poor chemical and physic

Externí odkaz: https://doaj.org/article/875d8e01b17d45da81fe8d488c49ed25

Zobrazit plný text záznamu

Akademický článek

A phage-displayed disulfide constrained peptide discovery platform yields novel human plasma protein binders.

Autor: Xinxin Gao, Harini Kaluarachchi, Yingnan Zhang, Sunhee Hwang, Rami N Hannoush

Publikováno v: PLoS ONE, Vol 19, Iss 3, p e0299804 (2024)

Disulfide constrained peptides (DCPs) show great potential as templates for drug discovery. They are characterized by conserved cysteine residues that form intramolecular disulfide bonds. Taking advantage of phage display technology, we designed and

Externí odkaz: https://doaj.org/article/db99f590e84746bab2f519d2511bd2b0

Zobrazit plný text záznamu

Akademický článek

Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

Autor: Jina Yun, Simon Hansen, Otto Morris, David T. Madden, Clare Peters Libeu, Arjun J. Kumar, Cameron Wehrfritz, Aaron H. Nile, Yingnan Zhang, Lijuan Zhou, Yuxin Liang, Zora Modrusan, Michelle B. Chen, Christopher C. Overall, David Garfield, Judith Campisi, Birgit Schilling, Rami N. Hannoush, Heinrich Jasper

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Cellular senescence and associated secretory phenotype (SASP) are thought to contribute to aging and tissue dysfunction, though it is unclear how SASP impacts regeneration. Here the authors show that SASP factors impair regeneration, and that Ptk7 is

Externí odkaz: https://doaj.org/article/0efe9bd563954738a88ecc378c67fcb4

Zobrazit plný text záznamu

Akademický článek

Fatty acylation enhances the cellular internalization and cytosolic distribution of a cystine-knot peptide

Autor: Xinxin Gao, Ann De Mazière, Rhiannon Beard, Judith Klumperman, Rami N. Hannoush

Publikováno v: iScience, Vol 24, Iss 11, Pp 103220- (2021)

Summary: Delivering peptides into cells could open up possibilities for targeting intracellular proteins. Although fatty acylation of peptide therapeutics improves their systemic half-life, it remains unclear how it influences their cellular uptake.

Externí odkaz: https://doaj.org/article/287ac2a1e17845f6811e652189cbfe08

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání