Synthesis and bioassay of 3-Aryl -1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]- triazin-4(3H)-ones as anti-cancer agents

Autor: Bassam Abu Thaher, Ihab Al-Masri, Kanan Wahedy, Rami Morjan, Saeb Aliwaini, Iman Mahmoud Al atter, Aayat Ahmed Elmabhouh, Areej khaled AL ibwaini, Saba Luay Alkhaldi, Basem Qeshta, Claus Jacob, Hans-Peter Deigner

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology.

Four novel 3-Aryl -1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]- triazin-4(3H)-ones derivatives (C1 to C4) have been designed, synthesized, and evaluated for their anticancer activity. The structure of compounds was characterized by IR,1H NMR, 13C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d686ded0bbf2bc5ba9bd9a26f7b11c
https://doi.org/10.1007/s00210-023-02433-5

Crystal structures of pure 3-(4-bromo-2-chloro­phen­yl)-1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]triazin-4(3H)-one and contaminated with 3-(4-bromo­phen­yl)-1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]triazin-4(3H)-one

Autor: Kanan Wahedy, Bassam Abu Thaher, Dieter Schollmeyer, Ihab Almasri, Rami Morjan, Basem Qeshta, Hans-Peter Deigner

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications, Vol 73, Iss 9, Pp 1341-1343 (2017)

The side product of the cyclo­condensation reaction between ethyl benzimidazole-2-carboxyl­ate and the nitrile imine of the corresponding hydrazonyl chloride, C20H11BrClN5O, crystallized in two crystal forms. Form (1) is a co-crystal of the target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba4f82d7d529f0efd06701ba7ab7735
http://europepmc.org/articles/PMC5588576

Synthesis and bioassay of 3-Aryl -1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]- triazin-4(3H)-ones as anti-cancer agents.

Autor: Thaher, Bassam Abu, Al-Masri, Ihab, Wahedy, Kanan, Morjan, Rami, Aliwaini, Saeb, Al atter, Iman Mahmoud, Elmabhouh, Aayat Ahmed, ibwaini, Areej khaled AL, Alkhaldi, Saba Luay, Qeshta, Basem, Jacob, Claus, Deigner, Hans-Peter

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology; Aug2023, Vol. 396 Issue 8, p1797-1810, 14p

Investigators at Islamic University of Gaza Discuss Findings in Breast Cancer [Synthesis and Bioassay of 3-aryl-1-(Pyridin-4-yl)Benzo[4,5] Imidazo[1,2-d][1,2,4]- Triazin-4(3h)-ones As Anti-cancer Agents].

Publikováno v: Women's Health Weekly; 4/18/2023, p369-369, 1p