Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Rami Käkönen"'
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Heparin-like polysaccharides reduce osteolytic bone destruction and tumor growth in a mouse model of breast cancer bone metastasis
Autor: Jussi M. Halleen, Khalid S. Mohammad, Sanna Maria Käkönen, Anni Wärri, Merja Perälä, Anne Marjamäki, Marjo Pihlavisto, Theresa A. Guise, Rami Käkönen, Olli Kallioniemi, Jukka P. Rissanen, Sirkku Pollari, Liisa Nissinen
Publikováno v: Pollari, S, Käkönen, R S, Mohammad, K S, Rissanen, J P, Halleen, J M, Wärri, A, Nissinen, L, Pihlavisto, M, Marjamäki, A, Perälä, M, Guise, T A, Kallioniemi, O & Käkönen, S-M 2012, ' Heparin-like polysaccharides reduce osteolytic bone destruction and tumor growth in a mouse model of breast cancer bone metastasis ', Molecular Cancer Research, vol. 10, no. 5, pp. 597-604 . https://doi.org/10.1158/1541-7786.MCR-11-0482
TGF-β regulates several steps in cancer metastasis, including the establishment of bone metastatic lesions. TGF-β is released from bone during osteoclastic bone resorption and it stimulates breast cancer cells to produce osteolytic factors such as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04db654cb6cf0dff2c8ed45a25806f83
https://cris.vtt.fi/en/publications/b94a935b-f2b8-4c76-bbad-a9084010e205
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3
O-Sulfated Bacterial Polysaccharides with Low Anticoagulant Activity Inhibit Metastasis
Autor: Markku Salmivirta, Anni Wärri, Anne Marjamäki, Rami Käkönen, Israel Vlodavsky, Sanna Maria Käkönen, Timo Veromaa, Benito Casu, Marjo Pihlavisto, Katri Hiilesvuo, Annamaria Naggi, Klaus Elenius, Marjut Borgenström, Giangiacomo Torri, Liisa Nissinen
Publikováno v: Seminars in Thrombosis and Hemostasis. 33:547-556
Heparin-like polysaccharides possess the capacity to inhibit cancer cell proliferation, angiogenesis, heparanase-mediated cancer cell invasion, and cancer cell adhesion to vascular endothelia via adhesion receptors, such as selectins. The clinical ap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1527f01e521b1d5b891bab8435ddd5de
https://doi.org/10.1055/s-2007-982087
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4
Survival benefit with radium-223 dichloride in a mouse model of breast cancer bone metastasis
Autor: Esa Alhoniemi, Sanna Maria Käkönen, Karl Ziegelbauer, Jukka P. Rissanen, Mari I. Suominen, Katja M. Fagerlund, Rami Käkönen, Jussi M. Halleen, Dominik Mumberg, Arne Scholz
Publikováno v: Journal of the National Cancer Institute. 105(12)
BACKGROUND Bone metastases are associated with increased morbidity and poor prognosis in breast cancer patients. Radium-223 dichloride is a calcium mimetic that localizes to bone, providing targeted therapy for skeletal metastasis. METHODS We investi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8905535daea3dc26adf1fee0a6867e26
https://pubmed.ncbi.nlm.nih.gov/23682134
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5
Detection of myeloma in skeleton of mice by whole-body optical fluorescence imaging
Autor: Steve Munoz, Christi L. Wideman, Babatunde O. Oyajobi, Barry Grubbs, Paul J. Williams, Gregory R. Mundy, Anjana Gupta, Rami Käkönen, I. Ross Garrett, William C. Dougall, Beryl Story, Allison P. Armstrong
Development of new therapies for myeloma has been hindered by the lack of suitable preclinical animal models of the disease in which widespread tumor foci in the skeleton can be detected reliably. Traditional means of detecting skeletal tumor infiltr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9753f4abb5e39078dddc279db20a94
https://europepmc.org/articles/PMC4482358/
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6
Effects of Cabozantinib Alone and in Combination with Bortezomib in the 5TGM1 Murine Multiple Myeloma Model
Autor: Mari I. Suominen, Jussi M. Halleen, Katja M. Fagerlund, Dana T. Aftab, Esa Alhoniemi, Jukka P. Rissanen, Rami Käkönen, Douglas O. Clary
Publikováno v: Blood. 124:3442-3442
Introduction: Cabozantinib (cabo) is an inhibitor of tyrosine kinases including MET, VEGFR2, RET, and the TAM family kinases TYRO3, AXL, and MER. Cabo has shown clinical activity in patients with castration-resistant prostate cancer and other solid t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::021d7d8c3287be53331fbb3fa1a38c05
https://doi.org/10.1182/blood.v124.21.3442.3442
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7
Abstract 734: Effects of Cabozantinib in the 5TGM1 murine multiple myeloma model
Autor: Esa Alhoniemi, Dana T. Aftab, Jussi M. Halleen, Mari I. Suominen, Rami Käkönen, Katja M. Fagerlund, Jukka P. Rissanen, Douglas O. Clary
Publikováno v: Cancer Research. 74:734-734
Cabozantinib is an inhibitor of tyrosine kinases including MET, VEGFR2, and RET, and has shown clinical activity in patients with castration-resistant prostate cancer and other solid tumors with bone metastases. Multiple myeloma (MM) is the second mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64239240da680144e25c6ee2696de673
https://doi.org/10.1158/1538-7445.am2014-734
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8
Abstract LB-105: Radium-223 dichloride monotherapy and combination therapy with zoledronic acid or doxorubicin improve survival in a mouse model of breast cancer bone metastasis
Autor: Sanna-Maria Käkönen, Jussi M. Halleen, Karl Ziegelbauer, Rami Käkönen, Mari I. Suominen, Jukka P. Rissanen, Dominik Mumberg, Esa Alhoniemi, Katja M. Fagerlund, Arne Scholz
Publikováno v: Cancer Research. 73:LB-105
Breast cancer metastasis to bone results in significant morbidity and poor prognosis. Radium-223 dichloride is an alpha-emitting calcium mimetic that localizes to bone and provides targeted radiation therapy. A phase III clinical study on prostate ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8053600bb6681093efcc5b8d28d549dd
https://doi.org/10.1158/1538-7445.am2013-lb-105
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9
Abstract 5712: Alpharadin (Radium-223 chloride) completely prevents tumor growth in bone and increases survival in a mouse model of breast cancer bone metastases in preventive and micro-metastatic settings
Autor: Dominik Mumberg, Arne Scholz, Jussi M. Halleen, Karl Ziegelbauer, Jukka P. Rissanen, Mari I. Suominen, Rami Käkönen
Publikováno v: Cancer Research. 72:5712-5712
Radium-223 chloride is an alpha-emitting radiopharmaceutical that has been shown to improve overall survival in the phase III clinical study (ALSYMPCA) in the treatment of castration resistant prostate cancer with bone metastases (Parker et al. ECCO/
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::258fb4d38dc3481a299aa9c00b2eb89d
https://doi.org/10.1158/1538-7445.am2012-5712
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10
Abstract 845: Heparin-like polysaccharides reduce osteolytic bone destruction and tumor growth in a mouse model of breast cancer bone metastasis
Autor: Sanna-Maria Käkönen, Jussi M. Halleen, Theresa A. Guise, Jukka P. Rissanen, Rami Käkönen, Khalid S. Mohammad, Anni Wärri, Liisa Nissinen, Marjo Pihlavisto, Olli Kallioniemi, Sirkku Pollari, Merja Perälä, Anne Marjamäki
Publikováno v: Cancer Research. 71:845-845
Transforming growth factor β (TGF-β) is a key regulator of several steps in cancer metastasis, including the establishment of bone metastatic lesions. TGF-β is released from bone during osteoclastic bone resorption and it stimulates breast cancer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fe64a31ded0f160cd3aac2568e2ed85
https://doi.org/10.1158/1538-7445.am2011-845
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