Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Rami Jaafar"'
Autor:
Flavia Letícia Martins Peçanha, Rami Jaafar, Joao Pedro Werneck-de-Castro, Charalampia-Christina Apostolopolou, Anil Bhushan, Ernesto Bernal-Mizrachi
Identifying the mechanisms behind the b-cell adaptation-to-failure is important to develop strategies to manage type 2 diabetes (T2D). Using db/db mice at early stages of the disease process, we took advantage of unbiased RNAseq to identify genes/pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d876c2e3af2d4239aa58a7e2454ac54
https://doi.org/10.2337/figshare.19723336
https://doi.org/10.2337/figshare.19723336
Autor:
Rémy Bonnavion, Rami Jaafar, Julie Kerr-Conte, Fouzia Assade, Esther van Stralen, Emmanuelle Leteurtre, Célio Pouponnot, Sofia Gargani, François Pattou, Philippe Bertolino, Martine Cordier-Bussat, Jieli Lu, Chang Xian Zhang
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72194 (2013)
Pax4 and MafA (v-maf musculoaponeurotic fibrosarcoma oncogene homolog A) are two transcription factors crucial for normal functions of islet beta cells in the mouse. Intriguingly, recent studies indicate the existence of notable difference between hu
Externí odkaz:
https://doaj.org/article/0be19846c33a4159930cbefa9ae61f41
Autor:
Gao Sun, Anil Bhushan, Avital Swisa, Simone Giacometti, Piero Marchetti, Matthias Hebrok, Matilde Masini, Aleksey V. Matveyenko, Rami Jaafar, Stella Tran, Ernesto Bernal-Mizrachi, Suneil K. Koliwad, Guy A. Rutter, Ajit Shah, Martin Valdearcos, Yuval Dor
Publikováno v:
The Journal of clinical investigation, vol 129, iss 10
Pancreatic beta cells (β-cells) differentiate during fetal life, but only postnatally acquire the capacity for glucose-stimulated insulin secretion (GSIS). How this happens is not clear. In exploring what molecular mechanisms drive the maturation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7b80d25f5b501f3672e10c0bf13f82
http://hdl.handle.net/11568/998100
http://hdl.handle.net/11568/998100
Autor:
Delphine Goehrig, Rami Jaafar, Ana Hennino, Jérémie Charbord, Chang X. Zhang, Martine Cordier-Bussat, Romain Teinturier, Doriane Ripoche, Olov Andersson, Rémy Bonnavion, Philippe Bertolino, Olli Ritvos
Loss of pancreatic β-cell maturity occurs in diabetes and insulinomas. Although both physiological and pathological stresses are known to promote β-cell dedifferentiation, little is known about the molecules involved in this process. Here we demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a970c158ed00d48ab15445e3b9f5c58
https://europepmc.org/articles/PMC4760219/
https://europepmc.org/articles/PMC4760219/
Autor:
Luciano Pirola, Etienne Lefai, Georges Némoz, Antonio Di Grazia, Fabio Naro, Rami Jaafar, Hubert Vidal, Caroline Zeiller
Publikováno v:
Journal of Biological Chemistry 25 (286), 22609-22621. (2011)
How phospholipase D (PLD) is involved in myogenesis remains unclear. At the onset of myogenic differentiation of L6 cells induced by the PLD agonist vasopressin in the absence of serum, mTORC1 complex was rapidly activated, as reflected by phosphoryl
Autor:
Florian Lepinasse, Doriane Ripoche, Marie-Christine Vantyghem, Jean-Yves Scoazec, Philippe Bertolino, François Pattou, Valérie Hervieu, Jens F. Rehfeld, Yuan-Jia Chen, Romain Teinturier, Rami Jaafar, Emmanuelle Leteurtre, Rémy Bonnavion, Chang Xian Zhang
The cells of origin of pancreatic gastrinomas remain an enigma, since no gastrin-expressing cells are found in the normal adult pancreas. It was proposed that the cellular origin of pancreatic gastrinomas may come from either the pancreatic cells the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28b4e5cd01a6dda15207a424d7a710c
https://europepmc.org/articles/PMC4561729/
https://europepmc.org/articles/PMC4561729/
Publikováno v:
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2013, 1828 (2), pp.602-13. ⟨10.1016/j.bbamem.2012.10.006⟩
BBA-Biochimica et Biophysica Acta, Elsevier, 2013, 1828 (2), pp.602-13. ⟨10.1016/j.bbamem.2012.10.006⟩
International audience; Lipid composition and fatty acid analysis of the major classes of membrane phospholipids were determined during myogenic differentiation of L6 skeletal muscle cells. The cholesterol to glycerophospholipids ratio decreased duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61020cbbbc3b21841844ab64d5650a22
https://hal.archives-ouvertes.fr/hal-00917344
https://hal.archives-ouvertes.fr/hal-00917344
Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling
Autor:
Philippe Bertolino, Christine Durand, Joffrey De Larichaudy, Vanessa Euthine, Stéphanie Chanon, Hubert Vidal, Rami Jaafar, Georges Némoz, Etienne Lefai, Fabio Naro
Publikováno v:
Cell Communication and Signaling
Cell Communication and Signaling, BioMed Central, 2013, 11 (1), pp.55. ⟨10.1186/1478-811X-11-55⟩
Cell Communication and Signaling (11), . (2013)
Cell Communication and Signaling : CCS
Cell Communication and Signaling, 2013, 11 (1), pp.55. ⟨10.1186/1478-811X-11-55⟩
Cell Communication and Signaling, BioMed Central, 2013, 11 (1), pp.55. ⟨10.1186/1478-811X-11-55⟩
Cell Communication and Signaling (11), . (2013)
Cell Communication and Signaling : CCS
Cell Communication and Signaling, 2013, 11 (1), pp.55. ⟨10.1186/1478-811X-11-55⟩
mTOR is a major actor of skeletal muscle mass regulation in situations of atrophy or hypertrophy. It is established that Phospholipase D (PLD) activates mTOR signaling, through the binding of its product phosphatidic acid (PA) to mTOR protein. An inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40108f6967eebae970628dddfdf41e1
https://www.hal.inserm.fr/inserm-00868745
https://www.hal.inserm.fr/inserm-00868745
Autor:
Philippe Bertolino, Doriane Ripoche, Johann Gout, Roxane M. Pommier, Chang X. Zhang, Laurent Bartholin, Rami Jaafar
Publikováno v:
Genesis (New York, N.Y. : 2000). 51(2)
Alk4 is a type I receptor that belongs to the transforming growth factor-beta (TGF-β) family. It takes part in the signaling of TGF-β ligands such as Activins, Gdfs, and Nodal that had been demonstrated to participate in numerous mechanisms ranging
Autor:
Georges Némoz, Michel Lagarde, Luciano Pirola, Saida Mebarek, Rami Jaafar, Caroline Zeiller, Annie-France Prigent
Publikováno v:
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2009, 1793 (7), pp.1236-49. ⟨10.1016/j.bbamcr.2009.04.001⟩
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2009, 1793 (7), pp.1236-49. ⟨10.1016/j.bbamcr.2009.04.001⟩
International audience; Endothelial permeability is controlled by adhesive strengths which connect cells to each other through interendothelial junctions and by contractile forces associated with cytoskeleton reorganization. Phospholipase D (PLD) act