Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Rami Al Batran"'
Publikováno v:
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2024 Jul; Vol. 39 (7), pp. 1450. Date of Electronic Publication: 2024 Apr 26.
Autor:
Stephanie Mourad, Abdualrahman Mohammed Abdualkader, Xiaobei Li, Shailee Jani, Rolando B. Ceddia, Rami Al Batran
Publikováno v:
Experimental Physiology, Vol 109, Iss 3, Pp 350-364 (2024)
Abstract Non‐alcoholic fatty liver disease (NAFLD) is projected to be the most common chronic liver disease worldwide and is closely linked to obesity, insulin resistance and type 2 diabetes. Currently, no pharmacological treatments are available t
Externí odkaz:
https://doaj.org/article/8aa6357aaacb4f15a81299f995fb6b9f
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 27 (2024)
Elevated levels of circulating branched-chain amino acids (BCAAs) and their associated metabolites have been strongly linked to insulin resistance and type 2 diabetes. Despite extensive research, the precise mechanisms linking increased BCAA levels w
Externí odkaz:
https://doaj.org/article/0e53105a49344e95a6a45ed9acbecc42
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 10 (2023)
Purpose of review: Glomerulonephritis refers to a rare group of diseases characterized by glomerular inflammation, which collectively are a common cause of kidney failure. Until recently, there was a lack of high-quality clinical trials to inform the
Externí odkaz:
https://doaj.org/article/08ab217732274b46a552171c82093f2f
Autor:
Golam M. Uddin, Liyan Zhang, Saumya Shah, Arata Fukushima, Cory S. Wagg, Keshav Gopal, Rami Al Batran, Simran Pherwani, Kim L. Ho, Jamie Boisvenue, Qutuba G. Karwi, Tariq Altamimi, David S. Wishart, Jason R. B. Dyck, John R. Ussher, Gavin Y. Oudit, Gary D. Lopaschuk
Publikováno v:
Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-12 (2019)
Abstract Background Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA accumulation occurs in patients with dilated cardiomyopathy (
Externí odkaz:
https://doaj.org/article/1825257d7b364b2bb61f4a044c96565b
Autor:
Keshav Gopal, Rami Al Batran, Tariq R. Altamimi, Amanda A. Greenwell, Christina T. Saed, Seyed Amirhossein Tabatabaei Dakhili, M. Toni E. Dimaano, Yongneng Zhang, Farah Eaton, Gopinath Sutendra, John R. Ussher
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108935- (2021)
Summary: Type 2 diabetes (T2D) increases the risk for diabetic cardiomyopathy and is characterized by diastolic dysfunction. Myocardial forkhead box O1 (FoxO1) activity is enhanced in T2D and upregulates pyruvate dehydrogenase (PDH) kinase 4 expressi
Externí odkaz:
https://doaj.org/article/c68c21dfb4204bab9f1c90e933d24e88
Autor:
Keshav Gopal, Abdualrahman Mohammed Abdualkader, Xiaobei Li, Amanda A. Greenwell, Qutuba G. Karwi, Christina Saed, Golam M. Uddin, Ahmed M. Darwesh, K Lockhart Jamieson, Tariq R. Altamimi, Ryekjang Kim, Farah Eaton, John M. Seubert, Gary D. Lopaschuk, John R. Ussher, Rami Al Batran
SUMMARYPyruvate dehydrogenase (PDH) is the rate-limiting enzyme for glucose oxidation that links glycolysis-derived pyruvate with the TCA cycle. Although skeletal muscle is a significant site for glucose oxidation and is closely linked with metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8354c8ea7210625299ebc48cd417067a
https://doi.org/10.1101/2023.05.10.540277
https://doi.org/10.1101/2023.05.10.540277
Autor:
Yean K. Yong, Alireza Saeidi, Hong Y. Tan, Mohamed Rosmawati, Philip F. Enström, Rami Al Batran, V. Vasuki, Indranil Chattopadhyay, Amudhan Murugesan, Ramachandran Vignesh, Adeeba Kamarulzaman, Jayakumar Rajarajeswaran, Abdul W. Ansari, Jamuna Vadivelu, James E. Ussher, Vijayakumar Velu, Marie Larsson, Esaki M. Shankar
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mucosal-associated invariant T (MAIT) cells, defined as CD161++TCR iVα7.2+ T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections. Here, we investigated the
Externí odkaz:
https://doaj.org/article/3de5a270ec254a57b7a02d7dad1d335b
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2018)
Obesity and type 2 diabetes (T2D) increase the risk for cardiomyopathy, which is the presence of ventricular dysfunction in the absence of underlying coronary artery disease and/or hypertension. As myocardial energy metabolism is altered during obesi
Externí odkaz:
https://doaj.org/article/340f687229c24e099d0fa6cac671cde1
Publikováno v:
Diabetes. 71(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb66f278c0c80e442766c3efa5d22c4e
https://pubmed.ncbi.nlm.nih.gov/36265015
https://pubmed.ncbi.nlm.nih.gov/36265015