Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Rami A. Namas"'
Autor:
Fayten El-Dehaibi, Ruben Zamora, Josiah Radder, Jinling Yin, Ashti M. Shah, Rami A. Namas, Michelle Situ, Yanwu Zhao, William Bain, Alison Morris, Bryan J. McVerry, Derek A. Barclay, Timothy R. Billiar, Yingze Zhang, Georgios D. Kitsios, Yoram Vodovotz
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108333- (2023)
Summary: Acute inflammation is heterogeneous in critical illness and predictive of outcome. We hypothesized that genetic variability in novel, yet common, gene variants contributes to this heterogeneity and could stratify patient outcomes. We searche
Externí odkaz:
https://doaj.org/article/e6ad255c4d9d4059bc04de1506bd127e
Autor:
Junru Wu, Anthony Cyr, Danielle S. Gruen, Tyler C. Lovelace, Panayiotis V. Benos, Jishnu Das, Upendra K. Kar, Tianmeng Chen, Francis X. Guyette, Mark H. Yazer, Brian J. Daley, Richard S. Miller, Brian G. Harbrecht, Jeffrey A. Claridge, Herb A. Phelan, Brian S. Zuckerbraun, Matthew D. Neal, Pär I. Johansson, Jakob Stensballe, Rami A. Namas, Yoram Vodovotz, Jason L. Sperry, Timothy R. Billiar, PAMPer study group
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Alterations in lipid metabolism and circulating lipid species have been reported in patients with acute critical illness. Here the authors show that selective rise in systemic phosphatidylethanolamine levels is a common feature of critical illness th
Externí odkaz:
https://doaj.org/article/878ce1521f7b4769bceaa30dfe45f017
Autor:
Rami A. Namas, Maxim Mikheev, Jinling Yin, Derek Barclay, Bahiyyah Jefferson, Qi Mi, Timothy R. Billiar, Ruben Zamora, Jorg Gerlach, Yoram Vodovotz
Publikováno v:
Frontiers in Systems Biology, Vol 2 (2023)
Introduction: Systemic acute inflammation accompanies and underlies the pathobiology of sepsis but is also central to tissue healing. We demonstrated previously the in vivo feasibility of modulating the key inflammatory mediator tumor necrosis factor
Externí odkaz:
https://doaj.org/article/087deabccc294d3aa300bcd9a3fb6b09
Autor:
Nabil Azhar, Rami A. Namas, Khalid Almahmoud, Akram Zaaqoq, Othman A. Malak, Derek Barclay, Jinling Yin, Fayten El-Dehaibi, Andrew Abboud, Richard L. Simmons, Ruben Zamora, Timothy R. Billiar, Yoram Vodovotz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Systemic inflammation is complex and likely drives clinical outcomes in critical illness such as that which ensues following severe injury. We obtained time course data on multiple inflammatory mediators in the blood of blunt trauma patients
Externí odkaz:
https://doaj.org/article/eaee90484a5b42d6b93c66d1d070bc50
Autor:
Tianmeng Chen, Julia Conroy, Xinjun Wang, Michelle Situ, Rami A. Namas, Yoram Vodovotz, Wei Chen, Harinder Singh, Timothy R. Billiar
Publikováno v:
EBioMedicine, Vol 76, Iss , Pp 103860- (2022)
Summary: Background: While bulk and single cell transcriptomic patterns in circulating leukocytes from trauma patients have been reported, how these relate to changes in open chromatin patterns remain unstudied. Here, we investigated whether single-c
Externí odkaz:
https://doaj.org/article/78811d949ef74a1f8e8eba8f9f316fcc
Autor:
Lukas Schimunek, Haley Lindberg, Maria Cohen, Rami A. Namas, Qi Mi, Jinling Yin, Derek Barclay, Fayten El-Dehaibi, Andrew Abboud, Ruben Zamora, Timothy Robert Billiar, Yoram Vodovotz
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Systemic inflammation ensues following traumatic injury, driving immune dysregulation and multiple organ dysfunction (MOD). While a balanced immune/inflammatory response is ideal for promoting tissue regeneration, most trauma patients exhibit variabl
Externí odkaz:
https://doaj.org/article/47a5bf8f328d42819b0b0f381a9e8e1a
Autor:
Tianmeng Chen, Matthew J. Delano, Kong Chen, Jason L. Sperry, Rami A. Namas, Ashley J. Lamparello, Meihong Deng, Julia Conroy, Lyle L. Moldawer, Philip A. Efron, Patricia Loughran, Christopher Seymour, Derek C. Angus, Yoram Vodovotz, Wei Chen, Timothy R. Billiar
Publikováno v:
JCI Insight, Vol 6, Iss 2 (2021)
Immune dysfunction is an important factor driving mortality and adverse outcomes after trauma but remains poorly understood, especially at the cellular level. To deconvolute the trauma-induced immune response, we applied single-cell RNA sequencing to
Externí odkaz:
https://doaj.org/article/aa87caa1bd944fb59beac3cbabf37d4a
Autor:
Dongmei Liu, Rami A. Namas, Yoram Vodovotz, Andrew B. Peitzman, Richard L. Simmons, Hong Yuan, Qi Mi, Timothy R. Billiar
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Purpose: We sought to identify a MODS score parameter that highly correlates with adverse outcomes and then use this parameter to test the hypothesis that multiple severity-based MODS clusters could be identified after blunt trauma.Methods: MOD score
Externí odkaz:
https://doaj.org/article/9facb1ed0dd9402fa354ee00b837fab1
Autor:
Lukas Schimunek, Rami A. Namas, Jinling Yin, Derek Barclay, Dongmei Liu, Fayten el-Dehaibi, Andrew Abboud, Maria Cohen, Ruben Zamora, Timothy R. Billiar, Yoram Vodovotz
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Trauma is a leading cause of morbidity and mortality. It is unclear why some trauma victims follow a complicated clinical course and die, while others, with apparently similar injury characteristics, do not. Interpatient genomic differences, in the f
Externí odkaz:
https://doaj.org/article/6fb0e64f2e3c4b7383c5b79717dfc222
Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma
Autor:
Akram M. Zaaqoq, Rami A. Namas, Othman Abdul-Malak, Khalid Almahmoud, Derek Barclay, Jinling Yin, Ruben Zamora, Matthew R. Rosengart, Timothy R. Billiar, Yoram Vodovotz
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Animal studies suggest that the time of day is a determinant of the immunological response to both injury and infection. We hypothesized that due to this diurnal variation, time of injury could affect the systemic inflammatory response and outcomes p
Externí odkaz:
https://doaj.org/article/acaade017e1b4a0db49f462127fef377