Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Rami A Namas"'
Autor:
Timothy R Billiar, Danielle S Gruen, Yoram Vodovotz, Jinman Cai, Isabel Billiar, Mazen S Zenati, Greg Gaski, Rami A Namas
Publikováno v:
Trauma Surgery & Acute Care Open, Vol 6, Iss 1 (2021)
Background Trauma elicits a complex inflammatory response that, among multiple presenting factors, is greatly impacted by the magnitude of injury severity. Herein, we compared the changes in circulating levels of mediators with known proinflammatory
Externí odkaz:
https://doaj.org/article/38ab72fced0f40ba98935fbc39864ead
Autor:
Khalid Almahmoud, Andrew Abboud, Rami A Namas, Ruben Zamora, Jason Sperry, Andrew B Peitzman, Michael S Truitt, Greg E Gaski, Todd O McKinley, Timothy R Billiar, Yoram Vodovotz
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217577 (2019)
Extremity and soft tissue injuries contribute significantly to inflammation and adverse in-hospital outcomes for trauma survivors; accordingly, we examined the complex association between clinical outcomes inflammatory responses in this setting using
Externí odkaz:
https://doaj.org/article/a9b8869f0963496aa01b65aee3824226
Autor:
Cordelia Ziraldo, Yoram Vodovotz, Rami A Namas, Khalid Almahmoud, Victor Tapias, Qi Mi, Derek Barclay, Bahiyyah S Jefferson, Guoqiang Chen, Timothy R Billiar, Ruben Zamora
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e79804 (2013)
The translation of in vitro findings to clinical outcomes is often elusive. Trauma/hemorrhagic shock (T/HS) results in hepatic hypoxia that drives inflammation. We hypothesize that in silico methods would help bridge in vitro hepatocyte data and clin
Externí odkaz:
https://doaj.org/article/a0d369c29fa54ab282c965e5412d265c
Autor:
Rami A Namas, John Bartels, Rosemary Hoffman, Derek Barclay, Timothy R Billiar, Ruben Zamora, Yoram Vodovotz
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67419 (2013)
We combined in silico, in vivo, and in vitro studies to gain insights into age-dependent changes in acute inflammation in response to bacterial endotoxin (LPS). Time-course cytokine, chemokine, and NO2 (-/)NO3 (-) data from "middle-aged" (6-8 months
Externí odkaz:
https://doaj.org/article/ba34745516f048ce90234c4fb626ade5
Autor:
Rami A. Namas, Maxim Mikheev, Jinling Yin, Derek Barclay, Bahiyyah Jefferson, Qi Mi, Timothy R. Billiar, Ruben Zamora, Jorg Gerlach, Yoram Vodovotz
Publikováno v:
Frontiers in Systems Biology, Vol 2 (2023)
Introduction: Systemic acute inflammation accompanies and underlies the pathobiology of sepsis but is also central to tissue healing. We demonstrated previously the in vivo feasibility of modulating the key inflammatory mediator tumor necrosis factor
Externí odkaz:
https://doaj.org/article/087deabccc294d3aa300bcd9a3fb6b09
Autor:
Greg E. Gaski, Ruben Zamora, Yoram Vodovotz, Todd O. McKinley, Li Shen, Qing Sun, Timothy R. Billiar, Rami A. Namas
Publikováno v:
Journal of Trauma and Acute Care Surgery. 90:441-450
Background Multiply injured patients (MIPs) are at risk of complications including infections, and acute and prolonged organ dysfunction. The immunologic response to injury has been shown to affect outcomes. Recent advances in computational capabilit
Autor:
Othman Abdul-Malak, Yoram Vodovotz, Akram Zaaqoq, Jesse Guardado, Khalid Almahmoud, Jinling Yin, Brian Zuckerbraun, Andrew B. Peitzman, Jason Sperry, Timothy R. Billiar, Rami A. Namas
Publikováno v:
Mediators of Inflammation, Vol 2016 (2016)
We hypothesized that elevated base deficit (BD) ≥ 4 mEq/L upon admission could be associated with an altered inflammatory response, which in turn may impact differential clinical trajectories. Using clinical and biobank data from 472 blunt trauma s
Externí odkaz:
https://doaj.org/article/0604dd9290374aecb4ae5adb9916c780
Autor:
Timothy R. Billiar, Rami A. Namas, Fayten El-Dehaibi, Maria Cohen, Yoram Vodovotz, Yan Xu, Ashley J. Lamparello, A. Kaynar, Lukas Schimunek
Publikováno v:
Shock
Acute illness is a complex constellation of responses involving dysregulated inflammatory and immune responses, which are ultimately associated with multiple organ dysfunction. Gene association studies have associated single-nucleotide polymorphisms
Autor:
Upendra K. Kar, Ruben Zamora, Jillian Bonaroti, Yoram Vodovotz, Todd O. McKinley, Timothy R. Billiar, Jason L. Sperry, Rami A. Namas, Sultan S Abdelhamid
Publikováno v:
Antioxid Redox Signal
Significance: The immunoinflammatory responses that follow trauma contribute to clinical trajectory and patient outcomes. While remarkable advances have been made in trauma services and injury management, clarity on how the immune system in humans re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b65741f568aa4c5dc168b818f5bbdbac
https://europepmc.org/articles/PMC8905234/
https://europepmc.org/articles/PMC8905234/
Autor:
Rami A. Namas, Julia Arciero, Allison Torsey, Tyler Borgard, Jared Barber, Amy Carpenter, Yoram Vodovotz
Publikováno v:
Frontiers in Systems Biology. 1
Sepsis is characterized by an overactive, dysregulated inflammatory response that drives organ dysfunction and often results in death. Mathematical modeling has emerged as an essential tool for understanding the underlying complex biological processe