Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rami, Fishler"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Large amounts of net electrical charge are known to accumulate on inhaled aerosols during their generation using commonly-available inhalers. This effect often leads to superfluous deposition in the extra-thoracic airways at the cost of more
Externí odkaz:
https://doaj.org/article/306011bf76c64f9382d87fd055145334
Autor:
Rami Fishler, Yan Ostrovski, Avital Frenkel, Simon Dorfman, Mordechai Vaknin, Dan Waisman, Netanel Korin, Josué Sznitman
Publikováno v:
European Journal of Pharmaceutical Sciences. 181:106359
The applicability of inhalation therapy to some severe pulmonary conditions is often compromised by limited delivery rates (i.e. total dose) and low deposition efficiencies in the respiratory tract, most notably in the deep pulmonary acinar airways.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baa62ea576a0868f905a6734df2c6f8
https://doi.org/10.1016/j.ejps.2022.106359
https://doi.org/10.1016/j.ejps.2022.106359
Publikováno v:
Journal of Biomechanics. 140:111131
Treating diseased lung regions using inhalation therapy is often limited due to airway constrictions and obstructions that significantly reduce aerosol deposition efficiency. Intratracheal administration of liquid foams is a potential strategy to imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9deea20fbbbe5bb02e9761dc23efa1
https://doi.org/10.1016/j.jbiomech.2022.111131
https://doi.org/10.1016/j.jbiomech.2022.111131
Autor:
Avital Frenkel, Dan Waisman, Tali Haas, Rami Fishler, Vera Brod, Yan Ostrovski, Josué Sznitman, Simon Dorfman
Lung surfactant dysfunction has a critical role in the pathophysiology of acute respiratory distress syndrome (ARDS). Yet, efforts to treat ARDS patients with liquid instillations of exogenous surfactant have so far failed. One of the ongoing challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca31baf32c6246325e4646fc80608700
https://doi.org/10.1101/2020.11.30.403337
https://doi.org/10.1101/2020.11.30.403337
Autor:
Rami, Fishler, Josué, Sznitman
Publikováno v:
Inhalation. 11(3)
This article discusses a novel method to estimate aerodynamic particle size distributions (APSDs) of pharmaceutical aerosols through direct measurement of particle settling velocities using image-based analysis and particle tracking techniques. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a13b5eb06c670b3843ff45c0f3cc5c3
https://pubmed.ncbi.nlm.nih.gov/28690715
https://pubmed.ncbi.nlm.nih.gov/28690715
Publikováno v:
Microfluidics and Nanofluidics. 15:491-500
Low-Reynolds-number flows in cavities, characterized by separating and recirculating flows are increasingly used in microfluidic applications such as mixing and sorting of fluids, cells, or particles. However, there is still a lack of guidelines avai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91765819138922a2f5a451282e9da0d4
https://doi.org/10.1007/s10404-013-1166-0
https://doi.org/10.1007/s10404-013-1166-0
Publikováno v:
Journal of Biomechanics
The dispersion of inhaled microparticles in the pulmonary acinus of the lungs is often attributed to the complex interplay between convective mixing, due to irreversible flows, and intrinsic particle motion (i.e. gravity and diffusion). However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eec26879476edb59b4956ca2cd9e615
https://europepmc.org/articles/PMC5198889/
https://europepmc.org/articles/PMC5198889/
Autor:
Rami Fishler, Josué Sznitman
Publikováno v:
Journal of Visualized Experiments.
Quantifying respiratory flow characteristics in the pulmonary acinar depths and how they influence inhaled aerosol transport is critical towards optimizing drug inhalation techniques as well as predicting deposition patterns of potentially toxic airb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ebcd10efabd54948b47ba617c8df04
https://doi.org/10.3791/53588
https://doi.org/10.3791/53588
Autor:
Ron Wolchinsky, Yoram Reiter, Elad Peer, Tova Waks, Zelig Eshhar, Arbel Artzy-Schnirman, Rami Fishler, Reuven Brener, Uri Sivan
Publikováno v:
Nano Letters. 12:4992-4996
Nanoscale organization of surface ligands often has a critical effect on cell-surface interactions. We have developed an experimental system that allows a high degree of control over the 2-D spatial distribution of ligands. As a proof of concept, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155a8180ca1de5b9a6f06ea1878eb053
https://doi.org/10.1021/nl302619p
https://doi.org/10.1021/nl302619p
Publikováno v:
Biomicrofluidics
The entire luminal surface of the lungs is populated with a complex yet confluent, uninterrupted airway epithelium in conjunction with an extracellular liquid lining layer that creates the air-liquid interface (ALI), a critical feature of healthy lun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d62ed32835a45bf64655654768f45f
https://doi.org/10.1063/1.5023034
https://doi.org/10.1063/1.5023034