Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rameshu Rallabandi"'
Autor:
Jie Yin, Yanyong Kang, Aaron P. McGrath, Karen Chapman, Megan Sjodt, Eiji Kimura, Atsutoshi Okabe, Tatsuki Koike, Yuhei Miyanohana, Yuji Shimizu, Rameshu Rallabandi, Peng Lian, Xiaochen Bai, Mack Flinspach, Jef K. De Brabander, Daniel M. Rosenbaum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract The OX2 orexin receptor (OX2R) is a highly expressed G protein-coupled receptor (GPCR) in the brain that regulates wakefulness and circadian rhythms in humans. Antagonism of OX2R is a proven therapeutic strategy for insomnia drugs, and agoni
Externí odkaz:
https://doaj.org/article/9405c8a136a547eebb4d8f70de895b56
Autor:
Jie Yin, Yanyong Kang, Aaron P. McGrath, Karen Chapman, Megan Sjodt, Eiji Kimura, Atsutoshi Okabe, Tatsuki Koike, Yuhei Miyanohana, Yuji Shimizu, Rameshu Rallabandi, Peng Lian, Xiaochen Bai, Mack Flinspach, Jef K. De Brabander, Daniel M. Rosenbaum
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/9a0f713de8cb43e89a329843e0e714da
Autor:
Rameshu Rallabandi, Jon D. Rainier, Alexander Wade, Steven Lucas, Aruna Gorusupudi, Catrina Oberg, Paul S. Bernstein
Publikováno v:
Organic & Biomolecular Chemistry. 19:5563-5566
This article describes the synthesis of VLC-PUFA 32:6 n-3, D2-labeled 32:6 n-3, and the uptake of 32:6 n-3 into mouse retinal tissue.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23130998cda9290d0add6419bef26714
https://doi.org/10.1039/d1ob00491c
https://doi.org/10.1039/d1ob00491c
Autor:
Yang Xie, David G. McFadden, Xin Bai, Jiwoong Kim, Joel Liou, Xuecheng Ye, Hong Chen, Jef K. De Brabander, Bruce A. Posner, Rameshu Rallabandi, Luke M. Rice, Juan Manuel Povedano
Publikováno v:
Journal of Medicinal Chemistry
A phenotypic high-throughput screen identified a benzamide small molecule with activity against small cell lung cancer cells. A "clickable" benzamide probe was designed that irreversibly bound a single 50 kDa cellular protein, identified by mass spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9816a8aeca96bbee3b4612e4fa966a
http://europepmc.org/articles/PMC7707623
http://europepmc.org/articles/PMC7707623
Autor:
Victoria Cheng, Rameshu Rallabandi, Aruna Gorusupudi, Steven Lucas, Gregory Rognon, Paul S. Bernstein, Jon D. Rainier, John C. Conboy
Publikováno v:
Biophysical journal. 121(14)
The unique attributes of very-long-chain polyunsaturated fatty acids (VLC-PUFAs), their long carbon chains (n 24) and high degree of unsaturation, impart unique chemical and physical properties to this class of fatty acids. The changes imparted by VL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f2d16a38b446b07c653c634d4c38ed
https://pubmed.ncbi.nlm.nih.gov/35711144
https://pubmed.ncbi.nlm.nih.gov/35711144
Autor:
Juan Manuel Povedano, Vicky Li, Katherine E. Lake, Xin Bai, Rameshu Rallabandi, Jiwoong Kim, Yang Xie, Jef K. De Brabander, David G. McFadden
Publikováno v:
Cell Chemical Biology. 29:1325-1332.e4
Ewing sarcoma (EWS) is a pediatric malignancy driven by the EWSR1-FLI1 fusion protein formed by the chromosomal translocation t(11; 22). The small molecule TK216 was developed as a first-in-class direct EWSR1-FLI1 inhibitor and is in phase II clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47ef3341484ca5645a948fac2882d61
https://doi.org/10.1016/j.chembiol.2022.06.002
https://doi.org/10.1016/j.chembiol.2022.06.002
Autor:
Ranganathan Arunkumar, John C. Conboy, Paul S. Bernstein, Aruna Gorusupudi, Binxing Li, Gregory T. Rognon, Fu-Yen Chang, Alexander Wade, Jon D. Rainier, Rameshu Rallabandi, Steven Lucas, J. David Blount
Publikováno v:
Proc Natl Acad Sci U S A
Rare, nondietary very-long-chain polyunsaturated fatty acids (VLC-PUFAs) are uniquely found in the retina and a few other vertebrate tissues. These special fatty acids play a clinically significant role in retinal degeneration and development, but th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844f6b5aed01bfbc673d1f2ccbc562b4
https://doi.org/10.1073/pnas.2017739118
https://doi.org/10.1073/pnas.2017739118
Autor:
David G. McFadden, Deepak Nijhawan, J. de Brabander, Juan Manuel Povedano, Rameshu Rallabandi
Publikováno v:
Journal of Thoracic Oncology. 15:S28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d968e4a213299e02f1d614d7d5e9f6ef
https://doi.org/10.1016/j.jtho.2019.12.074
https://doi.org/10.1016/j.jtho.2019.12.074
Publikováno v:
Tetrahedron Letters. 56:3538-3540
Described herein is the generation and use of iodohexahydropyridoindolines and their free radical atom transfer reactions with aryl acetylenes to generate quaternary substituted pyridoindolones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c872ca9284f487ac9c4524f05e29ce3f
https://doi.org/10.1016/j.tetlet.2015.01.049
https://doi.org/10.1016/j.tetlet.2015.01.049
Publikováno v:
ChemInform. 46
Described herein is the generation and use of iodohexahydropyridoindolines and their free radical atom transfer reactions with aryl acetylenes to generate quaternary substituted pyridoindolones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58ac67c28bf3646b32995ceee1ec3125
https://doi.org/10.1002/chin.201539151
https://doi.org/10.1002/chin.201539151