Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ramesh V, Nair"'
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Skin serves as both barrier and interface between body and environment. Skin microbes are intermediaries evolved to respond, transduce, or act in response to changing environmental or physiological conditions. We quantified genome-wide changes in gen
Externí odkaz:
https://doaj.org/article/124ba7c62a6c4fa597138693bfb50fd4
Autor:
Sarasa Isobe, Ramesh V. Nair, Helen Y. Kang, Lingli Wang, Jan-Renier Moonen, Tsutomu Shinohara, Aiqin Cao, Shalina Taylor, Shoichiro Otsuki, David P. Marciano, Rebecca L. Harper, Mir S. Adil, Chongyang Zhang, Mauro Lago-Docampo, Jakob Körbelin, Jesse M. Engreitz, Michael P. Snyder, Marlene Rabinovitch
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Pulmonary arterial hypertension (PAH) is a progressive disease in which pulmonary arterial (PA) endothelial cell (EC) dysfunction is associated with unrepaired DNA damage. BMPR2 is the most common genetic cause of PAH. We report that human P
Externí odkaz:
https://doaj.org/article/77e16fe3567e4a3f89266732e6c31cf1
Autor:
Lauren J. Donovan, Caldwell M. Bridges, Amy R. Nippert, Meng Wang, Shaogen Wu, Thomas E. Forman, Elena S. Haight, Nolan A. Huck, Sabrina F. Bond, Claire E. Jordan, Aysha M. Gardner, Ramesh V. Nair, Vivianne L. Tawfik
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113683- (2024)
Summary: Microglia are implicated as primarily detrimental in pain models; however, they exist across a continuum of states that contribute to homeostasis or pathology depending on timing and context. To clarify the specific contribution of microglia
Externí odkaz:
https://doaj.org/article/2e3aed2af006405d84986f37d5ad267b
Autor:
Jan-Renier Moonen, James Chappell, Minyi Shi, Tsutomu Shinohara, Dan Li, Maxwell R. Mumbach, Fan Zhang, Ramesh V. Nair, Joseph Nasser, Daniel H. Mai, Shalina Taylor, Lingli Wang, Ross J. Metzger, Howard Y. Chang, Jesse M. Engreitz, Michael P. Snyder, Marlene Rabinovitch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors studied pulmonary arterial endothelial cells (PAEC) under laminar shear stress and show that this physiologic condition markedly changes chromatin accessibility at regulatory regions, when compared to cells grown in a static state. T
Externí odkaz:
https://doaj.org/article/dd0de669b721470b8265ca8d188386af
Autor:
Andrew J. Gentles, Angela Bik-Yu Hui, Weiguo Feng, Armon Azizi, Ramesh V. Nair, Gina Bouchard, David A. Knowles, Alice Yu, Youngtae Jeong, Alborz Bejnood, Erna Forgó, Sushama Varma, Yue Xu, Amanda Kuong, Viswam S. Nair, Rob West, Matt van de Rijn, Chuong D. Hoang, Maximilian Diehn, Sylvia K. Plevritis
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background Tumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and
Externí odkaz:
https://doaj.org/article/cc0f2098680f4d72b3ab8a49201dc29f
Autor:
HyunTae V. Hwang, Nefthi Sandeep, Ramesh V. Nair, Dong‐Qing Hu, Mingming Zhao, Ingrid S. Lan, Giovanni Fajardo, Scot J. Matkovich, Daniel Bernstein, Sushma Reddy
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 4 (2021)
Background In complex congenital heart disease patients such as those with tetralogy of Fallot, the right ventricle (RV) is subject to pressure overload, leading to RV hypertrophy and eventually RV failure. The mechanisms that promote the transition
Externí odkaz:
https://doaj.org/article/4aa0a2c2786c44aa9266bd0e275a68b4
Autor:
Lauren J. Donovan, Caldwell M. Bridges, Amy R. Nippert, Meng Wang, Shaogen Wu, Thomas E. Forman, Elena S. Haight, Nolan A. Huck, Sabrina F. Bond, Claire E. Jordan, Aysha S. Gardner, Ramesh V. Nair, Vivianne L. Tawfik
SummaryMicroglia contribute to the initiation of pain, however, a translationally viable approach addressing how or when to modulate these cells remains elusive. We used a targeted, inducible, genetic microglial depletion strategy at both acute and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c76778da93eaa96c2bf6298953294e7f
https://doi.org/10.1101/2022.12.20.521295
https://doi.org/10.1101/2022.12.20.521295
Autor:
Ting-Hsuan Wu, Lingfang Shi, Jessika Adrian, Minyi Shi, Ramesh V Nair, Michael P Snyder, Peter N Kao
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193126 (2018)
NF90 and splice variant NF110 are DNA- and RNA-binding proteins encoded by the Interleukin enhancer-binding factor 3 (ILF3) gene that have been established to regulate RNA splicing, stabilization and export. The roles of NF90 and NF110 in regulating
Externí odkaz:
https://doaj.org/article/993d21b3a8234bad9895f205b264baa3
Autor:
Caldwell M. Bridges, Lauren J. Donovan, Amy R. Nippert, Meng Wang, Shaogen Wu, Thomas E. Forman, Elena S. Haight, Nolan A. Huck, Claire E. Jordan, Aysha S. Gardner, Ramesh V. Nair, Vivianne L. Tawfik
Publikováno v:
The Journal of Pain. 24:5-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eb2aea23322ff33ffb2fa165eaf0e47
https://doi.org/10.1016/j.jpain.2023.02.020
https://doi.org/10.1016/j.jpain.2023.02.020
Autor:
Yili Zhu, Aihui Wang, Grace M. Allard, Joshua J. Nordberg, Ramesh V. Nair, Christian A. Kunder, Alarice C. Lowe
Publikováno v:
Cancer cytopathologyREFERENCES. 130(10)
Effective cancer treatment relies on precision diagnostics. In cytology, an accurate diagnosis facilitates the determination of proper therapeutics for patients with cancer. Previously, the authors developed a multiplexed immunofluorescent panel to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314e69bc101e94ad23d40ccf0a1ceace
https://pubmed.ncbi.nlm.nih.gov/35731092
https://pubmed.ncbi.nlm.nih.gov/35731092