Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ramesh Subrahmanyam"'
Autor:
Roza Selimyan, Rachel M Gerstein, Irina Ivanova, Patricia Precht, Ramesh Subrahmanyam, Thomas Perlot, Frederick W Alt, Ranjan Sen
Publikováno v:
PLoS Biology, Vol 11, Iss 1, p e1001475 (2013)
Multiple epigenetic marks have been proposed to contribute to the regulation of antigen receptor gene assembly via V(D)J recombination. Here we provide a comprehensive view of DNA methylation at the immunoglobulin heavy chain (IgH) gene locus prior t
Externí odkaz:
https://doaj.org/article/da7279c959ba4adf98b054966dd8c55f
Autor:
Ashish Lal, Hyeon Ho Kim, Kotb Abdelmohsen, Yuki Kuwano, Rudolf Pullmann, Subramanya Srikantan, Ramesh Subrahmanyam, Jennifer L Martindale, Xiaoling Yang, Fariyal Ahmed, Francisco Navarro, Derek Dykxhoorn, Judy Lieberman, Myriam Gorospe
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1864 (2008)
Expression of the tumor suppressor p16(INK4a) increases during aging and replicative senescence.Here, we report that the microRNA miR-24 suppresses p16 expression in human diploid fibroblasts and cervical carcinoma cells. Increased p16 expression wit
Externí odkaz:
https://doaj.org/article/141f3df44cd24439bdc4dd836d1595e1
Autor:
Fayez Estephan, Coen Lap, Maneesh Rajiv Jain, Victor Nava, Alexandra Zara Rozalen, Morgan Byrne, Guoqing Diao, Ramesh Subrahmanyam, Rithika Rajendran, Antonio Martha, Jeff Banagan
Publikováno v:
Journal of Clinical Oncology. 41:212-212
212 Background: The HER2 oncogene serves as a prognostic marker in breast cancer and is a therapeutic target in breast, lung, and GI malignancies, including cancers with low Her2 overexpression. A prior study by Minner et al ( Clin Cancer Res, 2010)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f2e50dc6d0b7e706dc08fd97479972b
https://doi.org/10.1200/jco.2023.41.6_suppl.212
https://doi.org/10.1200/jco.2023.41.6_suppl.212
Autor:
Ramesh Subrahmanyam, Paula N. Friedman, Mohammed Shaazuddin, Edith A. Nutescu, Matthew Tuck, Myurani Sathyanarayanan, Jeff Banagan, Courtney L. Scherr, Diana Moreno, Honghong Zhang, Tharani Jeyaram, Mary Harris, Adriana Rodriguez, Minoli A. Perera, Mohammed Nooruddin
Publikováno v:
Ethn Dis
Objective: To identify reasons for nonparticipation by African Americans in cardiovascular pharmacogenomic research. Design: Prospective, open-ended, qualitative survey. Setting: Research staff approached patients eligible for the Discovery Pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e422c9601938678a674d8bc6d903ef4
https://pubmed.ncbi.nlm.nih.gov/32269457
https://pubmed.ncbi.nlm.nih.gov/32269457
Autor:
Frederick W. Alt, Irina Ivanova, David G. Schatz, Yanhong Ji, Tirtha Chakraborty, Hansen Du, Ramesh Subrahmanyam, Ranjan Sen, Yu Zhang
Publikováno v:
Nature immunology
Genes encoding immunoglobulin heavy chains (Igh) are assembled by rearrangement of variable (V(H)), diversity (D(H)) and joining (J(H)) gene segments. Three critical constraints govern V(H) recombination. These include timing (V(H) recombination foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c664bdcc042ebbe7e31216211502806
http://europepmc.org/articles/PMC3685187
http://europepmc.org/articles/PMC3685187
Autor:
Ramesh Subrahmanyam, Qing Yu, Thomas Ried, Mai Xu, Michael J. Difilippantonio, Jyoti Misra Sen
Publikováno v:
Molecular and Cellular Biology. 28:1713-1723
The expression of beta-catenin, a potent oncogene, is causally linked to tumorigenesis. Therefore, it was surprising that the transgenic expression of oncogenic beta-catenin in thymocytes resulted in thymic involution instead of lymphomagenesis. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cde46a22a30a8aef71596bd2990733
https://doi.org/10.1128/mcb.01360-07
https://doi.org/10.1128/mcb.01360-07
Publikováno v:
Immunity. 27(4):561-571
SummaryV(D)J recombination is initiated by the recombination activating gene (RAG) proteins RAG-1 and RAG-2. The ability of antigen-receptor-gene segments to undergo V(D)J recombination is correlated with spatially- and temporally-restricted chromati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afe265387c6014902a0ee3dc82cabe3
Autor:
Irina Ivanova, Dipanjan Chowdhury, Tirtha Chakraborty, Ranjan Sen, Amanda Keyes, Ramesh Subrahmanyam, Anant Jani
Publikováno v:
Molecular Cell. 27(5):842-850
Summary The first steps of murine immunoglobulin heavy-chain (IgH) gene recombination take place within a chromosomal domain that contains diversity (D H ) and joining (J H ) gene segments, but not variable (V H ) gene segments. Here we show that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d09ad14ea8d9bd08959981649eb45ce
Publikováno v:
Cancer Research. 67:7139-7146
RAS proteins are small GTPases that play a central role in transducing signals that regulate cell proliferation, survival, and differentiation. The RAS proteins interact with a common set of activators and effectors; however, they associate with diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6dc16d51bcffc998567a61c7df7da89
https://doi.org/10.1158/0008-5472.can-07-0778
https://doi.org/10.1158/0008-5472.can-07-0778
Publikováno v:
Blood. 108:2349-2357
Activating mutations in RAS, predominantly NRAS, are common in myeloid malignancies. Previous studies in animal models have shown that oncogenic NRAS is unable to induce myeloid malignancies effectively, and it was suggested that oncogenic NRAS might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8c398b957f4880265b40c8d3bea708
https://doi.org/10.1182/blood-2004-08-009498
https://doi.org/10.1182/blood-2004-08-009498