Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ramesh Srirangam"'
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 28:618-627
The objective of this study was to determine the ocular bioavailability of hesperidin and hesperetin, especially with respect to their distribution into the posterior segment of the eye, following systemic and topical administration in rabbits.Hesper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed01e9bdabb0887a933d8129dae3404
https://doi.org/10.1089/jop.2012.0040
https://doi.org/10.1089/jop.2012.0040
Publikováno v:
Journal of Pharmaceutical Sciences. 101:1631-1638
Hesperidin, a flavanone glycoside, and its aglycone hesperetin are potential candidates for the treatment of diabetic retinopathy and macular edema. The objective of this study was to delineate vitreal pharmacokinetics of hesperidin and hesperetin an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d3f23f187e99cf20d91d20bffbca2e
https://doi.org/10.1002/jps.23047
https://doi.org/10.1002/jps.23047
Autor:
Ramesh Srirangam, Soumyajit Majumdar
Publikováno v:
International Journal of Pharmaceutics. 394:60-67
Hesperetin, an aglycone of the flavanone hesperidin, is a potential candidate for the treatment of diabetic retinopathy and macular edema. The purpose of this investigation was to determine solubility, stability and in vitro permeability characterist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367ff967a09985da1c1158e4fa7f4f75
https://doi.org/10.1016/j.ijpharm.2010.04.036
https://doi.org/10.1016/j.ijpharm.2010.04.036
Evaluation of active and passive transport processes in corneas extracted from preserved rabbit eyes
Publikováno v:
Journal of Pharmaceutical Sciences. 99:1921-1930
In vitro transcorneal permeability studies are an important screening tool in drug development. The objective of this research is to examine the feasibility of using corneas isolated from preserved rabbit eyes as a model for permeability evaluation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89a62581449205650b9e9e0fad2c5bc
https://doi.org/10.1002/jps.21979
https://doi.org/10.1002/jps.21979
Autor:
Sunil Kumar Battu, Soumyajit Majumdar, Sampada B. Upadhye, Michael A. Repka, Ramesh Srirangam
Publikováno v:
Expert Opinion on Drug Delivery. 5:1357-1376
In today’s pharmaceutical arena, it is estimated that more than 40% of new chemical entities produced during drug discovery efforts exhibit poor solubility characteristics. However, over the last decade hot-melt extrusion (HME) has emerged as a pow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d559512d70c448c0455dbff5ce41f97b
https://doi.org/10.1517/17425240802583421
https://doi.org/10.1517/17425240802583421
Autor:
Soumyajit Majumdar, John M. Rimoldi, Ramesh Srirangam, Michael A. Repka, Tushar Hingorani, Rama S.V. Gadepalli
Publikováno v:
Pharmaceutical Research. 26:1261-1269
The aim of this study was to evaluate the contribution of amino acid transporters in the transcorneal permeation of the aspartate (Asp) ester acyclovir (ACV) prodrug.Physicochemical characterization, solubility and stability of acyclovir L-aspartate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f70f7138a38da3b456095b136f74830
https://doi.org/10.1007/s11095-008-9730-0
https://doi.org/10.1007/s11095-008-9730-0
Publikováno v:
BMJ case reports. 2012
A case of a 41-year-old patient presenting late post-trauma with out any major signs or symptoms is presented herewith. On radiological investigation, a peculiar foreign body was identified in the orbital floor. To our surprise the point of entry of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d14bfc67942e0bfde0b4600a33f4bd
https://pubmed.ncbi.nlm.nih.gov/22891015
https://pubmed.ncbi.nlm.nih.gov/22891015
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 38(10)
The objective of the present study was to investigate the effect of topically coadministered P-glycoprotein (P-gp) substrates/inhibitors on the vitreal kinetics of a systemically administered P-gp substrate. Anesthetized male rabbits were used in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068429049d2fb0978b8a927c6968bbad
https://pubmed.ncbi.nlm.nih.gov/20595378
https://pubmed.ncbi.nlm.nih.gov/20595378
The purpose of this study was to investigate whether topically administered P-glycoprotein (P-gp) substrates/modulators can alter vitreal kinetics of intravitreally administered quinidine. Male New Zealand rabbits were used under anesthesia. Vitreal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991ea81d1f4597438a25528a699e77c9
https://europepmc.org/articles/PMC2712438/
https://europepmc.org/articles/PMC2712438/
Autor:
Soumyajit Majumdar, Ramesh Srirangam
Hesperidin holds potential in treating age-related macular degeneration, cataract and diabetic retinopathy. The aim of this study, constituting the first step towards efficient ocular delivery of hesperidin, was to determine its physicochemical prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbabc6741a612cae545b7144786a9c20
https://europepmc.org/articles/PMC2664388/
https://europepmc.org/articles/PMC2664388/