Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ramesh Padmanabha"'
Autor:
Jeremy H. Toyn, Lorin A. Thompson, Kimberley A. Lentz, Jere E. Meredith, Catherine R. Burton, Sethu Sankaranararyanan, Valerie Guss, Tracey Hall, Lawrence G. Iben, Carol M. Krause, Rudy Krause, Xu-Alan Lin, Maria Pierdomenico, Craig Polson, Alan S. Robertson, R. Rex Denton, James E. Grace, John Morrison, Joseph Raybon, Xiaoliang Zhuo, Kimberly Snow, Ramesh Padmanabha, Michele Agler, Kim Esposito, David Harden, Margaret Prack, Sam Varma, Victoria Wong, Yingjie Zhu, Tatyana Zvyaga, Samuel Gerritz, Lawrence R. Marcin, Mendi A. Higgins, Jianliang Shi, Cong Wei, Joseph L. Cantone, Dieter M. Drexler, John E. Macor, Richard E. Olson, Michael K. Ahlijanian, Charles F. Albright
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2014 (2014)
Alzheimer’s disease is the most prevalent cause of dementia and is associated with accumulation of amyloid-β peptide (Aβ), particularly the 42-amino acid Aβ1-42, in the brain. Aβ1-42 levels can be decreased by γ-secretase modulators (GSM), whi
Externí odkaz:
https://doaj.org/article/1dce320132d4411583a19dcbfe2b54ae
Autor:
Charu Chaudhry, Ping Zhang, Kyoung S. Kim, William J. Pitts, Cornelius Lyndon A M, Lynn M. Abell, Hart Amy C, Kevin O’Malley, Junqing Guo, Brian Carpenter, Hao Lu, Ramesh Padmanabha, Patrick J. Shaw, Mertzman Michael E, Kevin Kish, Andrew E Douglas, Matthew Pokross, John E. Macor, Deepa Calambur, Carolyn A. Weigelt
Publikováno v:
ACS Med Chem Lett
[Image: see text] Necroptosis has been implicated in a variety of disease states, and RIPK3 is one of the kinases identified to play a critical role in this signaling pathway. In an effort to identify RIPK3 kinase inhibitors with a novel profile, mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2ff1dc1b611e09babd108893b9d371
https://doi.org/10.1021/acsmedchemlett.9b00065
https://doi.org/10.1021/acsmedchemlett.9b00065
Autor:
John Morrison, Kenneth M. Boy, Alan S. Robertson, Malaz AbuTarif, Jeremy H. Toyn, Valerie Guss, Xiaoliang Zhuo, Maciej Gasior, James E. Grace, Cong Wei, Jun-Sheng Wang, Quan Hong, Joseph Raybon, Lynda S. Cook, Nina Hoque, Richard E. Olson, Wendy Clarke, Rex Denton, Lorin A. Thompson, Francis Sweeney, Flora Berisha, Jere E. Meredith, Dieter M. Drexler, Holly Soares, Kimberly A. Lentz, Charlie F. Albright, Ramesh Padmanabha, Michael J. Furlong, John E. Macor, Michael K. Ahlijanian, Dmitry Zuev, Kimberly Snow
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
The amyloid-β peptide (Aβ)-in particular, the 42-amino acid form, Aβ1-42-is thought to play a key role in the pathogenesis of Alzheimer's disease (AD). Thus, several therapeutic modalities aiming to inhibit Aβ synthesis or increase the clearance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c27817650721b910af7d1d2e922680b
https://doi.org/10.1124/jpet.116.232249
https://doi.org/10.1124/jpet.116.232249
Autor:
John E. Macor, Ramesh Padmanabha, Jere E. Meredith, Jeremy H. Toyn, William J. Metzler, Andrew J. Tebben, Jodi K. Muckelbauer, Charles F. Albright, Lynda S. Cook, Lorin A. Thompson, Samuel Gerritz, Michael J. Sofia, Michael A. Poss, Shirong Zhu, Lawrence G. Iben, Daniel M. Camac, Kimberley A. Lentz, Shuhao Shi, Andrew C. Good, Weixu Zhai, Catherine R. Burton
Publikováno v:
Journal of Medicinal Chemistry. 55:9208-9223
This report describes the discovery and optimization of a BACE-1 inhibitor series containing an unusual acyl guanidine chemotype that was originally synthesized as part of a 6041-membered solid-phase library. The synthesis of multiple follow-up solid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf4562a5f10ca9a8478ab177aed261b
https://doi.org/10.1021/jm300931y
https://doi.org/10.1021/jm300931y
Autor:
Bang-Chi Chen, Neil Flynn, R. Michael Lawrence, Rulin Zhao, Ching-Hsuen Chu, James J. Li, Vito G. Sasseville, Scott A. Biller, Luping Chen, Randy Ponticiello, Haixia Wang, Dora M. Schnur, Dong Cheng, Jamil Haris, Jeffrey A. Robl, Kristen Pike, Joseph A. Tino, Mary T. Obermeier, Thomas Harrity, Timothy F. Herpin, Ramesh Padmanabha
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3208-3211
A novel series of 2-hydroxy-N-arylbenzenesulfonamides were identified to be ATP-citrate lyase (ACL) inhibitors with compound 9 displaying potent in vitro activity (IC(50)=0.13 microM). Chronic oral dosing of compound 9 in high-fat fed mice lowered pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863f1596275d02b6a6a0c62e58561a4d
https://doi.org/10.1016/j.bmcl.2007.03.017
https://doi.org/10.1016/j.bmcl.2007.03.017
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 8:521-527
Changes in all aspects of HTS from compound management through to evaluation of hits and leads, strengthened by infrastructure improvements, in both automation and informatics, have made possible increased analysis and implementation of process and q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4384b581bea9ed6e4525d8d77346197
https://doi.org/10.2174/1386207054867274
https://doi.org/10.2174/1386207054867274
Autor:
Henry Wong, John J. Herbst, Kin Sing Lam, Kim Esposito, Shuhao Shi, Samuel Gerritz, Yue Zhong Shu, Michael J. Sofia, Wenying Li, Ramesh Padmanabha, Shirong Zhu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4151-4154
The solid-phase synthesis of a library based on the natural product anisomycin is described. The resulting library was tested against a panel of bacterial and fungal targets, and active compounds were identified in a Staphylococcus aureus whole-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca00f94bd0e656010279e323914fb0b7
https://doi.org/10.1016/j.bmcl.2005.06.004
https://doi.org/10.1016/j.bmcl.2005.06.004
Autor:
Lynda S. Cook, Laura Zawadzke, Ramesh Padmanabha, Ping Wu, Margaret Casperson, Li Fan, Mona Kishnani, Deepa Calambur, Hofstead Sandra J
Publikováno v:
Analytical Biochemistry. 314:243-252
Assays for two enzymes from Escherichia coli were developed and validated as antibacterial inhibitor screens. The MraY and MurG enzymes were overexpressed and purified as the membrane fraction or to homogeneity, respectively. The MurG enzyme was expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd7dc7293a579b40034c3417bc5f4de
https://doi.org/10.1016/s0003-2697(02)00622-x
https://doi.org/10.1016/s0003-2697(02)00622-x
Autor:
Ramesh Padmanabha, Samuel Gerritz, Lorin A. Thompson, Joseph L. Cantone, Michele Agler, Dieter M. Drexler, Tracey Hall, David G. Harden, Rudy Krause, Charles F. Albright, Tatyana Zvyaga, Xiaoliang Zhuo, Victoria Wong, Jianliang Shi, Craig Polson, James E. Grace, Jeremy H. Toyn, Kim Esposito, Kimberly Snow, Valerie Guss, Maria Pierdomenico, John Morrison, Lawrence R. Marcin, Sam Varma, Jere E. Meredith, Cong Wei, Sethu Sankaranararyanan, John E. Macor, Mendi A. Higgins, Kimberley A. Lentz, Xu-Alan Lin, Joseph Raybon, Carol M. Krause, Michael K. Ahlijanian, Margaret M. Prack, Catherine R. Burton, Lawrence G. Iben, Richard E. Olson, Alan S. Robertson, Rex Denton, Yingjie Zhu
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2014 (2014)
International Journal of Alzheimer's Disease
International Journal of Alzheimer's Disease
Alzheimer’s disease is the most prevalent cause of dementia and is associated with accumulation of amyloid-βpeptide (Aβ), particularly the 42-amino acid Aβ1-42, in the brain. Aβ1-42 levels can be decreased byγ-secretase modulators (GSM), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a200c84c75814b878131607c3b7c2d
Autor:
Lynda S. Cook, Susan P. Manly, Marcella Donovan, Susan E. Lowe, Yue-Zhong Shu, Ramesh Padmanabha, Judith A. Veitch, Dolores M. Pirnik, Stella Huang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:569-574
A high-throughput screen was developed and implemented to identify inhibitors of the Lck tyrosine kinase. This report describes the identification of a specific inhibitor of this enzyme from the solid fermentation culture of the Penicillium sp., WC75
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e83f4ca03d309fff4d0848936cefa1e
https://doi.org/10.1016/s0960-894x(98)00072-9
https://doi.org/10.1016/s0960-894x(98)00072-9