Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ramesh Mudududdla"'
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1530 (2023)
Antiretrovirals (ARVs) are a highly effective therapy for treatment and prevention of HIV infection, when administered as prescribed. However, adherence to lifelong ARV regimens poses a considerable challenge and places HIV patients at risk. Long-act
Externí odkaz:
https://doaj.org/article/94384584fd5f4aa5bf15e2bd634b06a2
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 303 (2023)
Drug targeting is necessary to deliver drugs to a specific site of action at a rate dictated by therapeutic requirements. The pharmacological action of a drug can thereby be optimised while minimising adverse effects. Numerous colonic drug delivery s
Externí odkaz:
https://doaj.org/article/f5c66296317f42a89799f9685098aeb0
Autor:
Punsaldulam Dashnyam, Ramesh Mudududdla, Tung-Ju Hsieh, Ting-Chien Lin, Hsien-Ya Lin, Peng-Yuan Chen, Chia-Yi Hsu, Chun-Hung Lin
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Gut bacterial β-D-glucuronidases (GUSs) catalyze the removal of glucuronic acid from liver-produced β-D-glucuronides. These reactions can have deleterious consequences when they reverse xenobiotic metabolism. The human gut contains hundred
Externí odkaz:
https://doaj.org/article/0b6371ff0cd6400d83e8e0397189f8c8
Autor:
Sandip Bibishan Bharate, Nagaraju Mupparapu, Sudhakar Manda, Jaideep B. Bharate, Ramesh Mudududdla, Rammohan R. Yadav, Ram A. Vishwakarma
Publikováno v:
ARKIVOC, Vol 2012, Iss 8, Pp 308-318 (2012)
Externí odkaz:
https://doaj.org/article/e1738c8a228346cf8c02116e1d9ece5b
Autor:
Ajay Kumar, Parul Khajuria, Mehboob Ali, Mohd Abdullaha, Ramesh Mudududdla, Dilpreet Kour, Sandip B. Bharate
Publikováno v:
ACS Pharmacology & Translational Science. 4:1437-1448
Nucleotide-binding domain leucine-rich repeat family pyrin domain containing 3 (NLRP3) inflammasome complex regulates the caspase-1 activity and subsequent processing of interleukin-1β (IL-1β). Various inflammatory diseases involve the activation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::220e2b121064463627bcbda510cab544
https://doi.org/10.1021/acsptsci.1c00126
https://doi.org/10.1021/acsptsci.1c00126
Autor:
Ian P. Street, Benjamin Cleary, Jonathan B. Baell, Jessica M. Strasser, Daniel L. Priebbenow, Hendrik Falk, Michael W. Parker, Susan A. Charman, H. Rachel Lagiakos, Brendon J. Monahan, Michael A. Walters, M.C. Chung, S.J. Hermans, Natalie L. Downer, Matthew E. Cuellar, Jayme L. Dahlin, Helene Jousset Sabroux, Tim Thomas, David J. Leaver, Swapna Varghese, Lian Xue, Karen L. White, Yuxin Sun, Prashant Mujumdar, Kasiram Katneni, Silvia Teguh, Anne K. Voss, Julie Sanchez, Kate E. Jarman, David M. Shackleford, Fei Huang, Ramesh Mudududdla, Nghi Nguyen
Publikováno v:
Journal of Medicinal Chemistry. 63:4655-4684
A high-throughput screen designed to discover new inhibitors of histone acetyltransferase KAT6A uncovered CTX-0124143 (1), a unique aryl acylsulfonohydrazide with an IC50 of 1.0 μM. Using this acylsulfonohydrazide as a template, we herein disclose t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eaf3a6eb34ac40b5b8c570155ff2a49
https://doi.org/10.1021/acs.jmedchem.9b02071
https://doi.org/10.1021/acs.jmedchem.9b02071
Publikováno v:
European journal of medicinal chemistry. 227
Indoloquinoline (IQ) is an important class of naturally occurring antimalarial alkaloids, mainly represented by cryptolepine, isocryptolepine, and neocryptolepine. The IQ structural framework consists of four isomeric ring systems differing via the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544366c0da7db03c9b254cd63cbb1a39
https://pubmed.ncbi.nlm.nih.gov/34710743
https://pubmed.ncbi.nlm.nih.gov/34710743
Autor:
Siu Wai, Wong, Lucy, Vivash, Ramesh, Mudududdla, Nghi, Nguyen, Stefan J, Hermans, David M, Shackleford, Judith, Field, Lian, Xue, Andrea, Aprico, Nancy C, Hancock, Mohammad, Haskali, Michael A, Stashko, Stephen V, Frye, Xiaodong, Wang, Michele D, Binder, Uwe, Ackermann, Michael W, Parker, Trevor J, Kilpatrick, Jonathan B, Baell
Publikováno v:
European journal of medicinal chemistry. 226
MER tyrosine kinase (MERTK) upregulation is associated with M2 polarization of microglia, which plays a vital role in neuroregeneration following damage induced by neuroinflammatory diseases such as multiple sclerosis (MS). Therefore, a radiotracer s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea044071cb613468cbef9f4ec7ab324d
https://pubmed.ncbi.nlm.nih.gov/34563964
https://pubmed.ncbi.nlm.nih.gov/34563964
Publikováno v:
European Journal of Pharmaceutical Sciences. 128:118-127
Aggregated Aβ peptides which cause amyloid deposits, a characteristic of Alzheimer's disease (AD), activate a stress response in the endoplasmic reticulum (ER), known as the unfolded protein response, UPRER. Nascent UPRER induction helps in reducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58a0b73ded58a52b118715de1d1d6add
https://doi.org/10.1016/j.ejps.2018.11.029
https://doi.org/10.1016/j.ejps.2018.11.029
Autor:
Mohd, Abdullaha, Mehboob, Ali, Dilpreet, Kour, Ramesh, Mudududdla, Parul, Khajuria, Ajay, Kumar, Sandip B, Bharate
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Nucleotide-binding domain leucine-rich repeat family pyrin domain containing 3 (NLRP3) inflammasome complex regulates the caspase-1 activity and subsequent processing of interleukin-1β (IL-1β). Various inflammatory diseases involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4d4850fb29611482aeb56c9ce5dee13
https://pubmed.ncbi.nlm.nih.gov/34423275
https://pubmed.ncbi.nlm.nih.gov/34423275