Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ramesh Gujjar"'
Autor:
Jennifer L Guler, Daniel L Freeman, Vida Ahyong, Rapatbhorn Patrapuvich, John White, Ramesh Gujjar, Margaret A Phillips, Joseph DeRisi, Pradipsinh K Rathod
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003375 (2013)
Malaria drug resistance contributes to up to a million annual deaths. Judicious deployment of new antimalarials and vaccines could benefit from an understanding of early molecular events that promote the evolution of parasites. Continuous in vitro ch
Externí odkaz:
https://doaj.org/article/148359ae87cb4845b008ba25d4f7734c
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2237 (2008)
Mycobacterium tuberculosis kills approximately 2 million people each year and presents an urgent need to identify new targets and new antitubercular drugs. Thymidylate synthase (TS) enzymes from other species offer good targets for drug development a
Externí odkaz:
https://doaj.org/article/94a1603ed18743c884c2d568540607b2
Autor:
Steven G. Kinsey, Emma Leishman, Molly S. Crowe, Ramesh Gujjar, Matthew L. Banks, Heather B. Bradshaw, Anu Mahadevan
Publikováno v:
British Journal of Pharmacology. 172:1700-1712
Background and Purpose Neuropathic pain is commonly treated with GABA analogues, steroids or non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit one or more COX isozymes but chronic COX inhibition paradoxically increases gastrointestinal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79178205dd1bbdcd07635bc47a6f228a
https://doi.org/10.1111/bph.13012
https://doi.org/10.1111/bph.13012
Autor:
Pranamee Sarma, Esther Martinez-Martinez, Ramesh Gujjar, Pierre-Yves Desprez, Mukkanti Amere, Jonathon Judkins, Eiman Elwakeel, Sean D. McAllister, Rumi Kawamura, Ryuichi Murase, Eric Singer, Anu Mahadevan, Sonali Dayal, Arash Pakdel
Publikováno v:
British Journal of Pharmacology. 171:4464-4477
Background and Purpose The psychoactive cannabinoid Δ9-tetrahydrocannabinol (THC) and the non-psychoactive cannabinoid cannabidiol (CBD) can both reduce cancer progression, each through distinct anti-tumour pathways. Our goal was to discover a compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6b1f9246a3c4530b3996b260fa64efb
https://doi.org/10.1111/bph.12803
https://doi.org/10.1111/bph.12803
Autor:
Sharon A. Creason, Farah El Mazouni, Margaret A. Phillips, Alka Marwaha, Karen L. White, Pradip Rathod, John H. White, David M. Shackleford, Susan A. Charman, Ramesh Gujjar, Jeffrey Baldwin, Frederick S. Buckner, William N. Charman
Publikováno v:
Journal of Medicinal Chemistry. 52:1864-1872
Plasmodium faliciparum causes 1–2 million deaths annually, yet current drug therapies are compromised by resistance. We previously described potent and selective triazolopyrimidine-based inhibitors of P. falciparum dihydroorotate dehydrogenase (PfD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8dc316268f5255205533eb4df2b9569
https://doi.org/10.1021/jm801343r
https://doi.org/10.1021/jm801343r
Autor:
Molly S, Crowe, Emma, Leishman, Matthew L, Banks, Ramesh, Gujjar, Anu, Mahadevan, Heather B, Bradshaw, Steven G, Kinsey
Publikováno v:
British journal of pharmacology. 172(7)
Neuropathic pain is commonly treated with GABA analogues, steroids or non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit one or more COX isozymes but chronic COX inhibition paradoxically increases gastrointestinal inflammation and risk of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::408619540729baab6a93d2fff0c3b942
https://pubmed.ncbi.nlm.nih.gov/25393148
https://pubmed.ncbi.nlm.nih.gov/25393148
Autor:
Ryuichi, Murase, Rumi, Kawamura, Eric, Singer, Arash, Pakdel, Pranamee, Sarma, Jonathon, Judkins, Eiman, Elwakeel, Sonali, Dayal, Esther, Martinez-Martinez, Mukkanti, Amere, Ramesh, Gujjar, Anu, Mahadevan, Pierre-Yves, Desprez, Sean D, McAllister
Publikováno v:
British journal of pharmacology. 171(19)
The psychoactive cannabinoid Δ(9) -tetrahydrocannabinol (THC) and the non-psychoactive cannabinoid cannabidiol (CBD) can both reduce cancer progression, each through distinct anti-tumour pathways. Our goal was to discover a compound that could effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1a3bfa9c0ca8124a3966333e4abe099
https://pubmed.ncbi.nlm.nih.gov/24910342
https://pubmed.ncbi.nlm.nih.gov/24910342
Autor:
Margaret A. Phillips, David M. Shackleford, Xiaoyi Deng, Karen L. White, Ramesh Gujjar, Frederick S. Buckner, Ian Bathurst, Susan A. Charman, Sharon A. Creason, Jeremy N. Burrows, Pradipsinh K. Rathod, William N. Charman, Farah El Mazouni, David Matthews, David M. Floyd, John H. White
Publikováno v:
Journal of medicinal chemistry. 54(11)
Malaria is one of the leading causes of severe infectious disease worldwide; yet, our ability to maintain effective therapy to combat the illness is continually challenged by the emergence of drug resistance. We previously reported identification of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82a02b6bb25315522be5577e7cc5b69
https://pubmed.ncbi.nlm.nih.gov/21517059
https://pubmed.ncbi.nlm.nih.gov/21517059
Autor:
Margaret A. Phillips, Pradipsinh K. Rathod, Ramesh Gujjar, Xiaoyi Deng, Farah El Mazouni, Elizabeth J. Goldsmith, Nicholas A. Malmquist, Werner Kaminsky
Malaria remains a major global health burden and current drug therapies are compromised by resistance. Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) was validated as a new drug target through the identification of potent and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f70032b82f5d5fcf0da9d47d9b5bb8
https://europepmc.org/articles/PMC2785385/
https://europepmc.org/articles/PMC2785385/
Autor:
Joshua H. Hunter, Cullen K.T. Pang, Ramesh Gujjar, Devaraja G. Mudeppa, Ramulu Podutoori, Pradipsinh K. Rathod, Julie A. Bowman
The plant-like, bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) from malaria parasites has been a good target for drug development. Dihydrofolate reductase (DHFR) is inhibited by clinically established antimalarials, pyrimethamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0276457e5f2e5a7cf23ad67899e81bf7
https://europepmc.org/articles/PMC2741015/
https://europepmc.org/articles/PMC2741015/