Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ramesh Gopalaswamy"'
Autor:
Chul-Jin Lee, Xiaofei Liang, Qinglin Wu, Javaria Najeeb, Jinshi Zhao, Ramesh Gopalaswamy, Marie Titecat, Florent Sebbane, Nadine Lemaitre, Eric J. Toone, Pei Zhou
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
The conformational dynamics of a compound has a large effect on ligand/receptor binding. Here, the authors employ NMR spectroscopy to study ligand binding to the enzyme LpxC, discovering an inhibitor envelope that was not identifiable by crystallogra
Externí odkaz:
https://doaj.org/article/d7d0d77eb2224e92ad9e99b31e87c12f
Autor:
Ramesh Gopalaswamy, Lori A. Setton, Jonathan R. McDaniel, Ashutosh Chilkoti, David M. Gooden, S. Michael Sinclair, Jayanta Bhattacharyya
Publikováno v:
Journal of Controlled Release. 171:38-47
Radiculopathy, a painful neuroinflammation that can accompany intervertebral disc herniation, is associated with locally increased levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα). Systemic administration of TNF antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4e967e05007c69a0fd55e61d4a53ad
https://doi.org/10.1016/j.jconrel.2013.06.032
https://doi.org/10.1016/j.jconrel.2013.06.032
Publikováno v:
The Journal of organic chemistry. 81(10)
The difluoromethyl-allo-threonyl hydroxamate-based compound LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) in Gram-negative bacteria. A scalable synthesis of this compound is described. The key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d0c1255f5e03accc96da3d9c86b37f
https://pubmed.ncbi.nlm.nih.gov/27128325
https://pubmed.ncbi.nlm.nih.gov/27128325
Autor:
Jinshi Zhao, Florent Sebbane, Marie Titecat, Chul-Jin Lee, Xiaofei Liang, Nadine Lemaître, Javaria Najeeb, Eric J. Toone, Pei Zhou, Ramesh Gopalaswamy, Qinglin Wu
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes. Despite these well-established roles, such information has yet to be exploited for drug design.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b830d1cdc06a4fb0270ac97972157917
https://pubmed.ncbi.nlm.nih.gov/26912110
https://pubmed.ncbi.nlm.nih.gov/26912110
Publikováno v:
Experimental Brain Research. 136:351-363
This study characterizes trigeminal blinks in normal human subjects between 20 and 80 years of age, 60-year-old Parkinson's disease patients, and young and old guinea pigs. In normal humans over 60 years of age, lid-closing duration, and the excitabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1fa4651fd5a1bc18c853d4df0a0508
https://doi.org/10.1007/s002210000585
https://doi.org/10.1007/s002210000585
Autor:
Kevin Devito, Sabapathy Sankar, Brian Shull, Gerald Head, Ramesh Gopalaswamy, David Spielvogel
Publikováno v:
Journal of Pharmaceutical Sciences. 89:215-222
The complex of L-L-boronophenylalanine (L-p-BPA) with fructose has been used for the past 5 years in clinical trials of boron neutron capture therapy to treat both melanoma and glioblastoma multiforme. However, the structure of this complex in water
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b81a2c16531fd45a2ec8c4fb12b9cac4
https://doi.org/10.1002/(sici)1520-6017(200002)89:2<215::aid-jps8>3.0.co
https://doi.org/10.1002/(sici)1520-6017(200002)89:2<215::aid-jps8>3.0.co
Autor:
Gerald Head, Sabapathy Sankar, Paul D. Boyle, Ramesh Gopalaswamy, Brian Shull, David Spielvogel, Kevin Devito
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :557-561
The simple, straightforward 1H NMR spectrum of the neutron capture therapy drug, L-p-boronophenylalanine (L-p-BPA), in D2O changes to a more complex one in DMSO-d6 in which the ratio of new species observed is highly concentration dependent. The new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::670d51cedb5b324b9d41ac152eeacd1a
https://doi.org/10.1039/a906038c
https://doi.org/10.1039/a906038c
Publikováno v:
Journal of Computer-Aided Molecular Design. 11:93-110
Summary We report the application of a recently developed alignment-free 3D QSAR method [Crippen, G.M., J. Comput. Chem., 16 (1995) 486] to a benchmark-type problem. The test system involves the binding of 31 steroid compounds to two kinds of human c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0567e47a98510d4f4d4cb43a0318d64c
https://doi.org/10.1023/a:1008031629127
https://doi.org/10.1023/a:1008031629127
Publikováno v:
Tetrahedron Letters. 37:8267-8270
The synthesis of both syn- and anti-diol epoxide metabolites of triphenylene has been achieved under complete stereochemical control commencing with commercially available 9-phenanthrol in 18% (9 steps) and 37% (8 steps) overall yields, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9219e51bf5907a77a6622c453bc9f780
https://doi.org/10.1016/0040-4039(96)01896-5
https://doi.org/10.1016/0040-4039(96)01896-5
Autor:
Ramesh Gopalaswamy, Masato Koreeda
Publikováno v:
Tetrahedron Letters. 37:3651-3654
Stereo- and regioselective formation of bay-region bromo alcohols observed during etherbridge opening of the titled systems with boron tribromide has been rationalized, on the basis of AM1 calculations, by the intramolecular same-face delivery of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::704851bcbaee8338506a9392e26bcf9e
https://doi.org/10.1016/0040-4039(96)00664-8
https://doi.org/10.1016/0040-4039(96)00664-8