Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ramesh Chingle"'
Publikováno v:
Biomedicines, Vol 7, Iss 4, p 82 (2019)
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited malady affecting 12.5 million people worldwide. Therapeutic options to treat PKD are limited, due in part to lack of precise knowledge of underlying pathological mechanisms. Mimics
Externí odkaz:
https://doaj.org/article/1a8d29f1549a4a36b5cd444c83912d6d
Autor:
Stéphane Turcotte, Katia Mellal, Ramesh Chingle, Mukandila Mulumba, Samy Omri, Lylia Dif-Yaiche, Sylvain Chemtob, Huy Ong, William D. Lubell
Publikováno v:
Biomedicines, Vol 6, Iss 4, p 98 (2018)
Modulation of the cluster of differentiation-36 receptor (CD36) has proven promising for dampening pro-inflammatory macrophage signaling. For example, azapeptides (e.g., 1 and 2) bind CD36 selectively with high affinity, mitigate Toll-like receptor (
Externí odkaz:
https://doaj.org/article/1e4d6c5f99664b619bd18102e4c19a2d
Autor:
William D. Lubell, Ramesh Chingle, Huy Ong, Ragnhild G Ohm, Sylvain Chemtob, Mukandila Mulumba, Jinqiang Zhang, Ahsanullah
Publikováno v:
Journal of Medicinal Chemistry. 64:9365-9380
Cyclic peptide diversity has been broadened by elaborating the A3-macrocyclization to include various di-amino carboxylate components with different Ne-amine substituents. Triple-bond reduction provided new cyclic peptide macrocycles with Z-olefin an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b54fa0d7ff02f029f0a42f38cbcaf94f
https://doi.org/10.1021/acs.jmedchem.1c00642
https://doi.org/10.1021/acs.jmedchem.1c00642
Publikováno v:
Biopolymers. 106:235-244
Constrained azapeptides were designed based on the Ala-Val-Pro-Ile sequence from the second mitochondria-derived activator of caspases (Smac) protein and tested for ability to induce apoptosis in cancer cells. Diels-Alder cyclizations and Alder-ene r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f3eec4ff5b517add7f2ad439ee9a8de
https://doi.org/10.1002/bip.22851
https://doi.org/10.1002/bip.22851
Autor:
William D. Lubell, Katia Mellal, Huy Ong, Sylvain Chemtob, Lylia Dif-Yaiche, Ramesh Chingle, Samy Omri, Mukandila Mulumba, Stéphane Turcotte
Publikováno v:
Biomedicines
Volume 6
Issue 4
Biomedicines, Vol 6, Iss 4, p 98 (2018)
Volume 6
Issue 4
Biomedicines, Vol 6, Iss 4, p 98 (2018)
Modulation of the cluster of differentiation-36 receptor (CD36) has proven promising for dampening pro-inflammatory macrophage signaling. For example, azapeptides (e.g., 1 and 2) bind CD36 selectively with high affinity, mitigate Toll-like receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8afea974bcaa244d6925cf7f412afc8
Autor:
Ramesh Chingle
Publikováno v:
Ramesh Chingle
Les azapeptides sont des peptidomimétiques dans lesquels le carbone alpha d'un ou plusieurs acides aminés a été remplacé par un atome d'azote. L'objectif principal de cette étude doctorale a été de développer une nouvelle méthodologie de sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2a54caf58ceb1cbb430a590ebdec6314
https://hdl.handle.net/1866/20753
https://hdl.handle.net/1866/20753
Publikováno v:
Accounts of chemical research. 50(7)
Mimicry of bioactive conformations is critical for peptide-based medicinal chemistry because such peptidomimetics may augment stability, enhance affinity, and increase specificity. Azapeptides are peptidomimetics in which the α-carbon(s) of one or m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9eb06060f6aa09e76d0c5faf2a35b8
https://pubmed.ncbi.nlm.nih.gov/28598597
https://pubmed.ncbi.nlm.nih.gov/28598597
Publikováno v:
Peptide Science. :e24102
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84feb46cfd1b0a2982dcecc5704e7bfe
https://doi.org/10.1002/pep2.24102
https://doi.org/10.1002/pep2.24102
Autor:
Ramesh Chingle, William D. Lubell
Publikováno v:
Organic letters. 17(21)
Azopeptides possess an imino urea as an amino amide surrogate in the sequence. Azopeptides were synthesized by oxidation of aza-glycine residues and employed in pericyclic chemistry. Diels–Alder cyclizations and Alder–ene reactions on azopeptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc165d923d022072405939461841667
https://pubmed.ncbi.nlm.nih.gov/26509791
https://pubmed.ncbi.nlm.nih.gov/26509791
Autor:
William D. Lubell, Ramesh Chingle
Publikováno v:
Peptides 2015, Proceedings of the 24th American Peptide Symposium.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccffa6d5e1f10f18b46dbcd6ee7eb959
https://doi.org/10.17952/24aps.2015.172
https://doi.org/10.17952/24aps.2015.172