Next generation pan-cancer blood proteome profiling using proximity extension assay.

Autor: Álvez MB; Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden., Edfors F; Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden., von Feilitzen K; Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden., Zwahlen M; Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden., Mardinoglu A; Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden.; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 9RT, UK., Edqvist PH; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Sjöblom T; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Lundin E; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Rameika N; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Enblad G; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Lindman H; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Höglund M; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Hesselager G; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Stålberg K; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden., Enblad M; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Simonson OE; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Häggman M; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Axelsson T; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Åberg M; Department of Medical Sciences, Clinical Chemistry and SciLifeLab Affinity Proteomics, Uppsala University, Uppsala, Sweden., Nordlund J; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Zhong W; Science for Life Laboratory, Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden., Karlsson M; Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden., Gyllensten U; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Ponten F; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Fagerberg L; Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden., Uhlén M; Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden. mathias.uhlen@scilifelab.se.; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. mathias.uhlen@scilifelab.se.

Publikováno v: Nature communications [Nat Commun] 2023 Jul 18; Vol. 14 (1), pp. 4308. Date of Electronic Publication: 2023 Jul 18.

Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity.

Autor: Zhang X; Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden., Akcan E; Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden., Correia M; Department of Chemistry, BMC, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala, Sweden., Rameika N; Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden., Kundu S; Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden., Stoimenov I; Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden., Rendo V; Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02215, USA., Eriksson AU; Department of Chemistry, CBCS, KBC-C4, Umeå University, SE-901 87 UMEÅ, Sweden., Haraldsson M; Chemical Biology Consortium Sweden (CBCS), Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Globisch D; Department of Chemistry, BMC, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala, Sweden., Sjöblom T; Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden. Electronic address: tobias.sjoblom@igp.uu.se.

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2022 Sep; Vol. 203, pp. 115184. Date of Electronic Publication: 2022 Jul 22.

Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer.

Autor: Rendo V; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 85, Uppsala, Sweden.; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, 02215, USA., Kundu S; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 85, Uppsala, Sweden., Rameika N; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 85, Uppsala, Sweden., Ljungström V; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 85, Uppsala, Sweden., Svensson R; Uppsala Drug Optimization and Pharmaceutical Profiling Facility (UDOPP), SciLifeLab Chemical Biology Consortium Sweden (CBCS), Department of Pharmacy, Uppsala University, 751 23, Uppsala, Sweden.; SciLifeLab Drug Discovery and Development Platform, ADME of Therapeutics facility (UDOPP), Department of Pharmacy, Uppsala University, 751 23, Uppsala, Sweden., Palin K; Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Biomedicum Helsinki, P.O. Box 63, Haartmaninkatu 8, 00014, Helsinki, Finland.; Department of Medical and Clinical Genetics, University of Helsinki, Biomedicum Helsinki, P.O. Box 63, Haartmaninkatu 8, 00014, Helsinki, Finland., Aaltonen L; Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Biomedicum Helsinki, P.O. Box 63, Haartmaninkatu 8, 00014, Helsinki, Finland.; Department of Medical and Clinical Genetics, University of Helsinki, Biomedicum Helsinki, P.O. Box 63, Haartmaninkatu 8, 00014, Helsinki, Finland., Stoimenov I; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 85, Uppsala, Sweden., Sjöblom T; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 85, Uppsala, Sweden. tobias.sjoblom@igp.uu.se.

Publikováno v: Scientific reports [Sci Rep] 2020 Dec 31; Vol. 10 (1), pp. 22436. Date of Electronic Publication: 2020 Dec 31.

Cancer cell invasion alters the protein profile of extracellular vesicles.

Autor: Luoto, Jens C.^1,2 (AUTHOR), Coelho‐Rato, Leila S.^1,2 (AUTHOR), Jungarå, Cecilia¹ (AUTHOR), Bengs, Sara H.¹ (AUTHOR), Roininen, Jannica¹ (AUTHOR), Eriksson, John E.^1,2 (AUTHOR), Sistonen, Lea^1,2 (AUTHOR), Henriksson, Eva^1,2 (AUTHOR) eva.henriksson@abo.fi

Publikováno v: Journal of Extracellular Biology. Dec2023, Vol. 2 Issue 12, p1-15. 15p.

The Second Allele: A Key to Understanding the Timing of Sporadic and Hereditary Colorectal Tumorigenesis.

Autor: Abbass, Mohammed Ali, Leach, Brandie, Church, James Michael

Publikováno v: Genes; Oct2021, Vol. 12 Issue 10, p1515, 1p