Výsledky vyhledávání - "Rameez Jabeer Khan"

Akademický článek

Identification and prioritization of potential therapeutic molecules against LpxA from Acinetobacter baumannii – A computational study

Autor: Rameez Jabeer Khan, Ekampreet Singh, Rajat Kumar Jha, Ankit Kumar, Saurabh Kumar Bhati, Mahrukh Parveez Zia, Monika Jain, Rashmi Prabha Singh, Jayaraman Muthukumaran, Amit Kumar Singh

Publikováno v: Current Research in Structural Biology, Vol 5, Iss , Pp 100096- (2023)

A. baumannii is a ubiquitously found gram-negative, multi-drug resistant bacterial species from the ESKAPE family of pathogens known to be the causative agent for hospital-acquired infections such as pneumonia, meningitis, endocarditis, septicaemia a

Externí odkaz: https://doaj.org/article/ce58681dfa544474863fddaa482716b5

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Akademický článek

A comprehensive review on promising anti-viral therapeutic candidates identified against main protease from SARS-CoV-2 through various computational methods

Autor: Ekampreet Singh, Rameez Jabeer Khan, Rajat Kumar Jha, Gizachew Muluneh Amera, Monika Jain, Rashmi Prabha Singh, Jayaraman Muthukumaran, Amit Kumar Singh

Publikováno v: Journal of Genetic Engineering and Biotechnology, Vol 18, Iss 1, Pp 1-12 (2020)

Abstract Background The COVID-19 pandemic caused by SARS-CoV-2 has shown an exponential trend of infected people across the planet. Crediting its virulent nature, it becomes imperative to identify potential therapeutic agents against the deadly virus

Externí odkaz: https://doaj.org/article/972092af561240cbaf37ef3f69487358

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Akademický článek

Prioritization of Mur family drug targets against A. baumannii and identification of their homologous proteins through molecular phylogeny, primary sequence, and structural analysis

Autor: Gizachew Muluneh Amera, Rameez Jabeer Khan, Rajat Kumar Jha, Amita Pathak, Jayaraman Muthukumaran, Amit Kumar Singh

Publikováno v: Journal of Genetic Engineering and Biotechnology, Vol 18, Iss 1, Pp 1-22 (2020)

Abstract Background The World Health Organization (WHO) report stated that Acinetobacter baumannii had been classified as one of the most important pathogenic bacteria causing nosocomial infection in hospital patients due to multi-drug resistance (MD

Externí odkaz: https://doaj.org/article/9ce1d45d6ae642569bf4bdeb3a774a9b

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Akademický článek

Structure based in-silico study on UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase (MurE) from Acinetobacter baumannii as a drug target against nosocomial infections

Autor: Gizachew Muluneh Amera, Rameez Jabeer Khan, Amita Pathak, Ankit Kumar, Amit Kumar Singh

Publikováno v: Informatics in Medicine Unlocked, Vol 16, Iss , Pp - (2019)

UDP-N-acetylmuramoyl-L-alanyl-d-glutamate--2,6-diaminopimelate ligase (MurE) initiates reaction by adding meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-d-glutamate, during the synthesis of murein in the cytoplasm.

Externí odkaz: https://doaj.org/article/44296d7f04b249b2b8d8711291b7afdc

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Identifying the natural compound Catechin from tropical mangrove plants as a potential lead candidate against 3CLpro from SARS-CoV-2: An integrated in silico approach

Autor: A. Parthiban, Rajat Kumar Jha, Purvaja Ramachandran, V. Sachithanandam, Gizachew Muluneh Amera, Jayaraman Muthukumaran, Ekampreet Singh, Ramesh Ramachandran, Rashmi Singh, Monika Jain, Rameez Jabeer Khan, Amit Kumar Singh

Publikováno v: Journal of Biomolecular Structure and Dynamics. 40:13392-13411

SARS-CoV-2, a member of beta coronaviruses, is a single-stranded, positive-sense RNA virus responsible for the COVID-19 pandemic. With global fatalities of the pandemic exceeding 4.57 million, it becomes crucial to identify effective therapeutics aga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd985fbb895ede06e7182624fa5e4f49
https://doi.org/10.1080/07391102.2021.1988710

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A Comprehensive In Silico Study Towards Understanding the Inhibitory Mechanism of Lactoperoxidase by Dapsone and Propofol

Autor: Gizachew Muluneh Amera, Rashmi Singh, Rameez Jabeer Khan, Jayaraman Muthukumaran, Amit Kumar Singh, Rajat Kumar Jha

Publikováno v: Current Computer-Aided Drug Design. 17:550-559

Introduction: Lactoperoxidase (LPO) is a member of the mammalian heme peroxidase family and is an enzyme of the innate immune system. It possesses a covalently linked heme prosthetic group (a derivative of protoporphyrin IX) in its active site. LPO c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3711dc720ace1587b629e1a788ed2665
https://doi.org/10.2174/1573409916666200628104134

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Droperidol as a potential inhibitor of acyl-homoserine lactone synthase from A. baumannii: insights from virtual screening, MD simulations and MM/PBSA calculations

Autor: Rajat Kumar Jha, Ekampreet Singh, Rameez Jabeer Khan, Ankit Kumar, Monika Jain, Jayaraman Muthukumaran, Amit Kumar Singh

Publikováno v: Molecular Diversity.

A. baumannii belongs to the ESKAPE family of pathogens and is a multi-drug resistant, gram-negative bacteria which follows the anaerobic form of respiration. A. baumannii is known to be the causative agent of hospital-related infections such as pneum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd529b0a7b1c0ae2fe8a801d57a5b762
https://doi.org/10.1007/s11030-022-10533-2

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Targeting SARS-CoV-2: a systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2′-O-ribose methyltransferase

Autor: Rajat Kumar Jha, Amit Kumar Singh, Rashmi Singh, Rameez Jabeer Khan, Jayaraman Muthukumaran, Gizachew Muluneh Amera, Amita Pathak, Ekampreet Singh, Monika Jain

Publikováno v: Journal of Biomolecular Structure & Dynamics
Journal of Biomolecular Structure and Dynamics

The recent pandemic associated with SARS-CoV-2, a virus of the Coronaviridae family, has resulted in an unprecedented number of infected people. The highly contagious nature of this virus makes it imperative for us to identify promising inhibitors fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c3848d8e154275455bc9cb73466b82
http://europepmc.org/articles/PMC7189412

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