Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Rameez Ishaq"'
Autor:
Kahia Messaoudi, Ashfaq Ali, Rameez Ishaq, Alberta Palazzo, Dominika Sliwa, Olivier Bluteau, Sylvie Souquère, Delphine Muller, Khadija M. Diop, Philippe Rameau, Valérie Lapierre, Jean-Pierre Marolleau, Patrick Matthias, Isabelle Godin, Gérard Pierron, Steven G. Thomas, Stephen P. Watson, Nathalie Droin, William Vainchenker, Isabelle Plo, Hana Raslova, Najet Debili
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Histone deacetylase (HDAC) inhibitors, a class of cancer therapeutics, cause thrombocytopenia via an unknown mechanism. Here, the authors show that HDAC6 inhibition impairs proplatelet formation in human megakaryocytes, and show that this is linked t
Externí odkaz:
https://doaj.org/article/e6244d22664d4e168a0d548e8a713d18
Autor:
Jean-Pierre Marolleau, Delphine Muller, Dominika Sliwa, Khadija M. Diop, Steven G. Thomas, Gérard Pierron, Alberta Palazzo, Patrick Matthias, Nathalie Droin, Isabelle Godin, Isabelle Plo, Philippe Rameau, Hana Raslova, Sylvie Souquere, Stephen P. Watson, Kahia Messaoudi, Najet Debili, William Vainchenker, Olivier Bluteau, Rameez Ishaq, Ashfaq Ali, Valérie Lapierre
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8, ⟨10.1038/s41467-017-01690-2⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8, ⟨10.1038/s41467-017-01690-2⟩
Thrombocytopenia is a major side effect of a new class of anticancer agents that target histone deacetylase (HDAC). Their mechanism is poorly understood. Here, we show that HDAC6 inhibition and genetic knockdown lead to a strong decrease in human pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0853dae1f6256c46924ede75a1d0b7
http://link.springer.com/article/10.1038/s41467-017-01690-2
http://link.springer.com/article/10.1038/s41467-017-01690-2
Autor:
Najet Debili, Benoit Decouture, Sylvain Provot, Mari Kono, Eric Camerer, Ludovic Couty, Richard L. Proia, Maria L. Allende, Boubacar Mariko, Erica De Candia, Sonia Poirault-Chassac, Hira Niazi, Pierre-Louis Tharaux, Pierre Hadrien Becker, Véronique Baudrie, Christilla Bachelot-Loza, Rameez Ishaq, Nesrine Zoghdani, Anja Nitzsche, Alexandre Leuci, Yetki Aslan, Salome L. Gazit, Jerold Chun, Ammar Benarab, Patrice Therond, Pascale Gaussem
Publikováno v:
Blood Advances
Blood Advances, The American Society of Hematology, 2019, 3 (11), pp.1702-1713. ⟨10.1182/bloodadvances.2019031948⟩
Blood Advances, 2019, 3 (11), pp.1702-1713. ⟨10.1182/bloodadvances.2019031948⟩
Blood Advances, The American Society of Hematology, 2019, 3 (11), pp.1702-1713. ⟨10.1182/bloodadvances.2019031948⟩
Blood Advances, 2019, 3 (11), pp.1702-1713. ⟨10.1182/bloodadvances.2019031948⟩
International audience; Key points • The vascular S1Pgradient is dispensablefor platelet formationin mice• Instead, local S1P production restrains megakaryopoiesis via S1P 1 and can further suppress platelet production via S1P 2 when deregulated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2551795b23070694c0b2fa2f3eb1b57
https://www.hal.inserm.fr/inserm-02441591/document
https://www.hal.inserm.fr/inserm-02441591/document
Autor:
Rameez Ishaq, John D. Crispino, Yolande Chen, Praveen Suraneni, Najet Debili, Arinola Awomolo, Shirin Hasan, Michael Hession, Elizabeth A. Eklund, Seth J. Corey
Publikováno v:
Blood. 132:2429-2429
Abstract: Megakaryocytes (MKs) undergo directional migration from the proliferative osteoblastic niche within the bone marrow (BM) environment to the capillary-rich vascular niche for platelet production and release into the pulmonary circulation. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da91b675628e00f04ba6d62f763c830b
https://doi.org/10.1182/blood-2018-99-118782
https://doi.org/10.1182/blood-2018-99-118782