Zobrazeno 1 - 10
of 585
pro vyhledávání: '"Rameen Beroukhim"'
Autor:
Sean A. Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G. Doench, David E. Root, James M. McFarland, Rameen Beroukhim, Jesse S. Boehm
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Reducing disparities is vital for equitable access to precision treatments in cancer. Socioenvironmental factors are a major driver of disparities, but differences in genetic variation likely also contribute. The impact of genetic ancestry o
Externí odkaz:
https://doaj.org/article/f5fc9a4be68842a79c2275a29dc90764
Autor:
Christopher J. Ricketts, Aguirre A. De Cubas, Huihui Fan, Christof C. Smith, Martin Lang, Ed Reznik, Reanne Bowlby, Ewan A. Gibb, Rehan Akbani, Rameen Beroukhim, Donald P. Bottaro, Toni K. Choueiri, Richard A. Gibbs, Andrew K. Godwin, Scott Haake, A. Ari Hakimi, Elizabeth P. Henske, James J. Hsieh, Thai H. Ho, Rupa S. Kanchi, Bhavani Krishnan, David J. Kwiatkowski, Wenbin Liu, Maria J. Merino, Gordon B. Mills, Jerome Myers, Michael L. Nickerson, Victor E. Reuter, Laura S. Schmidt, C. Simon Shelley, Hui Shen, Brian Shuch, Sabina Signoretti, Ramaprasad Srinivasan, Pheroze Tamboli, George Thomas, Benjamin G. Vincent, Cathy D. Vocke, David A. Wheeler, Lixing Yang, William Y. Kim, A. Gordon Robertson, Paul T. Spellman, W. Kimryn Rathmell, W. Marston Linehan
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113063- (2024)
Externí odkaz:
https://doaj.org/article/53d6204d634d4e3487233c292d61e7e8
Autor:
Anna C. H. Hoge, Michal Getz, Anat Zimmer, Minjeong Ko, Linoy Raz, Rameen Beroukhim, Todd R. Golub, Gavin Ha, Uri Ben David
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-7 (2022)
Abstract Genomic evolution of patient-derived xenografts (PDXs) may lead to their gradual divergence away of their tumors of origin. We previously reported the genomic evolution of the copy number (CN) landscapes of PDXs during their engraftment and
Externí odkaz:
https://doaj.org/article/0ee932769b144f99adb5cd6d33e0312c
Autor:
Prasidda Khadka, Zachary J. Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M. Carvalho, Juliann Shih, Shu Zhang, Noah F. Greenwald, Travis Zack, Ofer Shapira, Kristine Pelton, Rachel Hartley, Heather Bear, Yohanna Georgis, Spandana Jarmale, Randy Melanson, Kevin Bonanno, Kathleen Schoolcraft, Peter G. Miller, Alexandra L. Condurat, Elizabeth M. Gonzalez, Kenin Qian, Eric Morin, Jaldeep Langhnoja, Leslie E. Lupien, Veronica Rendo, Jeromy Digiacomo, Dayle Wang, Kevin Zhou, Rushil Kumbhani, Maria E. Guerra Garcia, Claire E. Sinai, Sarah Becker, Rachel Schneider, Jayne Vogelzang, Karsten Krug, Amy Goodale, Tanaz Abid, Zohra Kalani, Federica Piccioni, Rameen Beroukhim, Nicole S. Persky, David E. Root, Angel M. Carcaboso, Benjamin L. Ebert, Christine Fuller, Ozgun Babur, Mark W. Kieran, Chris Jones, Hasmik Keshishian, Keith L. Ligon, Steven A. Carr, Timothy N. Phoenix, Pratiti Bandopadhayay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract The role of PPM1D mutations in de novo gliomagenesis has not been systematically explored. Here we analyze whole genome sequences of 170 pediatric high-grade gliomas and find that truncating mutations in PPM1D that increase the stability of
Externí odkaz:
https://doaj.org/article/05d88dcae9c94b0ba00bbf84c4d8c770
Autor:
Jonathan So, Nathaniel W. Mabe, Bernhard Englinger, Kin-Hoe Chow, Sydney M. Moyer, Smitha Yerrum, Maria C. Trissal, Joana G. Marques, Jason J. Kwon, Brian Shim, Sangita Pal, Eshini Panditharatna, Thomas Quinn, Daniel A. Schaefer, Daeun Jeong, David L. Mayhew, Justin Hwang, Rameen Beroukhim, Keith L. Ligon, Kimberly Stegmaier, Mariella G. Filbin, William C. Hahn
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Collateral lethality occurs when loss of a gene/protein renders cancer cells dependent on its remaining paralog. Combining genome-scale CRISPR/Cas9 loss-of-function screens with RNA sequencing in over 900 cancer cell lines, we found that cancers of n
Externí odkaz:
https://doaj.org/article/701d31e0fcdd484e84a5da699c9787f9
Autor:
Meng Zhou, Minjeong Ko, Anna C.H. Hoge, Kelsey Luu, Yuzhen Liu, Magdalena L. Russell, William W. Hannon, Zhenwei Zhang, Jian Carrot-Zhang, Rameen Beroukhim, Eliezer M. Van Allen, Atish D. Choudhury, Peter S. Nelson, Matthew L. Freedman, Mary-Ellen Taplin, Matthew Meyerson, Srinivas R. Viswanathan, Gavin Ha
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
The complex genomic landscape of prostate cancer evolves across disease states under therapeutic pressure directed toward inhibiting androgen receptor (AR) signaling. While significantly altered genes in prostate cancer have been extensively defined,
Externí odkaz:
https://doaj.org/article/6032eee655da4206a5a620a0aa119445
Autor:
Nyasha Chambwe, Rosalyn W. Sayaman, Donglei Hu, Scott Huntsman, Anab Kemal, Samantha Caesar-Johnson, Jean C. Zenklusen, Elad Ziv, Rameen Beroukhim, Andrew D. Cherniack, Jian Carrot-Zhang, Ashton C. Berger, Seunghun Han, Matthew Meyerson, Jeffrey S. Damrauer, Katherine A. Hoadley, Ina Felau, John A. Demchok, Michael K.A. Mensah, Roy Tarnuzzer, Zhining Wang, Liming Yang, Theo A. Knijnenburg, A. Gordon Robertson, Christina Yau, Christopher Benz, Kuan-lin Huang, Justin Y. Newberg, Garrett M. Frampton, R. Jay Mashl, Li Ding, Alessandro Romanel, Francesca Demichelis, Wanding Zhou, Peter W. Laird, Hui Shen, Christopher K. Wong, Joshua M. Stuart, Alexander J. Lazar, Xiuning Le, Ninad Oak
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101586- (2022)
Summary: Differential mRNA expression between ancestry groups can be explained by both genetic and environmental factors. We outline a computational workflow to determine the extent to which germline genetic variation explains cancer-specific molecul
Externí odkaz:
https://doaj.org/article/58eb09142b5d45b991b34126ef4e9377
Autor:
Kar-Tong Tan, Hyunji Kim, Jian Carrot-Zhang, Yuxiang Zhang, Won Jun Kim, Guillaume Kugener, Jeremiah A. Wala, Thomas P. Howard, Yueh-Yun Chi, Rameen Beroukhim, Heng Li, Gavin Ha, Seth L. Alper, Elizabeth J. Perlman, Elizabeth A. Mullen, William C. Hahn, Matthew Meyerson, Andrew L. Hong
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background Renal medullary carcinomas (RMCs) are rare kidney cancers that occur in adolescents and young adults of African ancestry. Although RMC is associated with the sickle cell trait and somatic loss of the tumor suppressor, SMARCB1, the
Externí odkaz:
https://doaj.org/article/500d30bc4a054d33b395ec98271cf7b5
Autor:
Caitlin A. Nichols, William J. Gibson, Meredith S. Brown, Jack A. Kosmicki, John P. Busanovich, Hope Wei, Laura M. Urbanski, Naomi Curimjee, Ashton C. Berger, Galen F. Gao, Andrew D. Cherniack, Sirano Dhe-Paganon, Brenton R. Paolella, Rameen Beroukhim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
In tumors, hundreds of genes can undergo loss of heterozygosity (LOH). Here, the authors investigate the potential for this LOH as a class of non-driver cancer vulnerabilities.
Externí odkaz:
https://doaj.org/article/86a1e531ffce47339d04b2ee5dc0b8e0
Autor:
Ninad Oak, Andrew D. Cherniack, R. Jay Mashl, TCGA Analysis Network, Fred R. Hirsch, Li Ding, Rameen Beroukhim, Zeynep H. Gümüş, Sharon E. Plon, Kuan-lin Huang
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-15 (2020)
Abstract Background Distinct prevalence of inherited genetic predisposition may partially explain the difference of cancer risks across ancestries. Ancestry-specific analyses of germline genomes are required to inform cancer genetic risk and prognosi
Externí odkaz:
https://doaj.org/article/de60882de0a144c695b5152ddc10189b