Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Ramaswamy Ramchandran"'
Autor:
Tianji Chen, Miranda R. Sun, Qiyuan Zhou, Alyssa M. Guzman, Ramaswamy Ramchandran, Jiwang Chen, Dustin R. Fraidenburg, Balaji Ganesh, Mark Maienschein-Cline, Karl Obrietan, J. Usha Raj
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 204-216 (2022)
MicroRNAs (miRNA, miR-) play important roles in disease development. In this study, we identified an anti-proliferative miRNA, miR-212-5p, that is induced in pulmonary artery smooth muscle cells (PASMCs) and lungs of pulmonary hypertension (PH) patie
Externí odkaz:
https://doaj.org/article/ed4623300a804178a3a77b18297d3b42
Autor:
Panfeng Fu, Yulia Epshtein, Ramaswamy Ramchandran, Joseph B. Mascarenhas, Anne E. Cress, Jeffrey Jacobson, Joe G. N. Garcia, Viswanathan Natarajan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract We have shown that both reactive oxygen species (ROS) and paxillin tyrosine phosphorylation regulate LPS-induced human lung endothelial permeability. Mitochondrial ROS (mtROS) is known to increase endothelial cell (EC) permeability which req
Externí odkaz:
https://doaj.org/article/1ec0f4a987774551a8f0d88321e35000
Autor:
Tianji Chen, Miranda R. Sun, Qiyuan Zhou, Alyssa M. Guzman, Ramaswamy Ramchandran, Jiwang Chen, Balaji Ganesh, J. Usha Raj
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 1, Pp n/a-n/a (2022)
Abstract In the lung, communication between pulmonary vascular endothelial cells (PVEC) and pulmonary artery smooth muscle cells (PASMC) is essential for the maintenance of vascular homeostasis. In pulmonary hypertension (PH), the derangement in thei
Externí odkaz:
https://doaj.org/article/8c4516715deb40d7b76699cd3f45aaf4
Autor:
Panfeng Fu, Ramaswamy Ramchandran, Tara Sudhadevi, Prasanth P. K. Kumar, Yashaswin Krishnan, Yuru Liu, Yutong Zhao, Narasimham L. Parinandi, Anantha Harijith, Junichi Sadoshima, Viswanathan Natarajan
Publikováno v:
Antioxidants, Vol 10, Iss 3, p 477 (2021)
Pseudomonas aeruginosa (PA) infection increases reactive oxygen species (ROS), and earlier, we have shown a role for NADPH oxidase-derived ROS in PA-mediated lung inflammation and injury. Here, we show a role for the lung epithelial cell (LEpC) NOX4
Externí odkaz:
https://doaj.org/article/72e4ebb45c71453b89d4a8af29de2223
Autor:
Yulia Epshtein, Ramaswamy Ramchandran, Anne E. Cress, Jeffrey R. Jacobson, Panfeng Fu, Joe G.N. Garcia, Joseph B Mascarenhas, Viswanathan Natarajan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
We have shown that both reactive oxygen species (ROS) and paxillin tyrosine phosphorylation regulate LPS-induced human lung endothelial permeability. Mitochondrial ROS (mtROS) is known to increase endothelial cell (EC) permeability which requires dyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31752cd14c5c4b461bae1846d33641a
https://doaj.org/article/1ec0f4a987774551a8f0d88321e35000
https://doaj.org/article/1ec0f4a987774551a8f0d88321e35000
Autor:
Panfeng Fu, Ramaswamy Ramchandran, David L. Ebenezer, Fabian Schumacher, Evgeny Berdyshev, Viswanathan Natarajan, Vidyani Suryadevara, Lizar A. Mangio, Alison W. Ha, Stephen J. Kron, Burkhard Kleuser, Paul P. Van Veldhoven
Publikováno v:
Cell Biochem Biophys
Sphingosine-1-phosphate (S1P), a bioactive lipid mediator, is generated from sphingosine by sphingosine kinases (SPHKs) 1 and 2 and is metabolized to ∆2-hexadecenal (∆2-HDE) and ethanolamine phosphate by S1P lyase (S1PL) in mammalian cells. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e267e33ce32b40f627c288a5090d5e5
https://doi.org/10.1007/s12013-021-01005-9
https://doi.org/10.1007/s12013-021-01005-9
Autor:
Ramaswamy Ramchandran, Mounica Bandela, Arjun Pennathur, Rama Kamesh Bikkavilli, Sreedevi Avasarala, Long Shuang Huang, Valerian E. Kagan, Xiangdong Zhu, Viswanathan Natarajan, Puttaraju S. Yashaswini, Yulia Y. Tyurina, Anantha Harijith, Prasanth-Kumar Punathil-Kannan, Michelle VanScoyk, Ravi Salgia, Sekhar P. Reddy, Tara Sudhadevi, Robert A. Winn, Sainath R. Kotha
Publikováno v:
J Biol Chem
Lysocardiolipin acyltransferase (LYCAT), a cardiolipin (CL)-remodeling enzyme, is crucial for maintaining normal mitochondrial function and vascular development. Despite the well-characterized role for LYCAT in the regulation of mitochondrial dynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce8bbf0cbff9dd5cf6aa93b6863a0e6
https://doi.org/10.1074/jbc.ra120.012680
https://doi.org/10.1074/jbc.ra120.012680
Autor:
Asrar B. Malik, Nicholas K. Tonks, Mark Shaaya, Guangwei Du, Viswanathan Natarajan, Long Shuang Huang, Panfeng Fu, Stephen M. Vogel, David L. Ebenezer, Ying Jiang, Ramaswamy Ramchandran, Yulia Komarova, Richard D. Minshall
Publikováno v:
J Biol Chem
Increased permeability of vascular lung tissues is a hallmark of acute lung injury and is often caused by edemagenic insults resulting in inflammation. Vascular endothelial (VE)-cadherin undergoes internalization in response to inflammatory stimuli a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ca5f1ef03214e7d9ee1ba9ba7c9b60
https://doi.org/10.1074/jbc.ra119.011801
https://doi.org/10.1074/jbc.ra119.011801
Autor:
Panfeng Fu, Ramaswamy Ramchandran, Steven M. Dudek, Narasimham L. Parinandi, Viswanathan Natarajan
Publikováno v:
Cardiovascular Signaling in Health and Disease ISBN: 9783031083082
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::117c0e4959ac70a88bfa5bc2f269f735
https://doi.org/10.1007/978-3-031-08309-9_17
https://doi.org/10.1007/978-3-031-08309-9_17
Autor:
Kamesh Bikkavilli, Mounica Bandela, Steven M. Dudek, Vidyani Suryadevara, Long Shuang Huang, Papasani V. Subbaiah, Lorraine B. Ware, Sekhar P. Reddy, Panfeng Fu, Sunit Singla, Ramaswamy Ramchandran, Viswanathan Natarajan, Sugasini Dhavamani
Publikováno v:
Cell biochemistry and biophysics. 80(1)
Cigarette smoke is the primary cause of Chronic Obstructive Pulmonary Disorder (COPD). Cigarette smoke extract (CSE)-induced oxidative damage of the lungs results in mitochondrial dysfunction and apoptosis of epithelium. Mitochondrial cardiolipin (CL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7aed5e597adaf1a5a8bbac40ea8093a
https://pubmed.ncbi.nlm.nih.gov/34724158
https://pubmed.ncbi.nlm.nih.gov/34724158