Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ramasastri Kambhampati"'
Autor:
Rajeshkumar Badange, Mukkanti Khagga, Renny Abraham, Amol D. Deshpande, Nageswararao Muddana, Ramasastri Kambhampati, Vishwottam Kandikere, Ramakrishna Nirogi, Vinaykumar Tiriveedhi, Anil Kashinath Chindhe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7431-7435
4-(Piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives were designed and synthesized as 5-HT6 receptor (5-HT6R) ligands. The lead compound 6a, from this series shows potent in vitro binding affinity, good PK profile, no CYP liabilities and acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1b04e6c8234289869682ff93ad8c82e
https://doi.org/10.1016/j.bmcl.2012.10.057
https://doi.org/10.1016/j.bmcl.2012.10.057
Autor:
Pradeep Jayarajan, Veena Reballi, Kumar Bojja, Nageswararao Muddana, Shinde Anil Karbhari, Mohammad Shaik, Ramasastri Kambhampati, Parandhama Gudla, Anand V. Daulatabad, Suresh Balasubramaniam, Ramakrishna Nirogi, Ramkumar Subramanian, Gampa Murlimohan, Rajeshkumar Badange, Gopinadh Bhyrapuneni, Pamuletinarasimhareddy Gangadasari
Publikováno v:
Journal of Medicinal Chemistry. 55:9255-9269
Our initial findings around aryl sulfonamide series led to N-(3,5-dichloro-2-methoxyphenyl)-3-(1-methylpiperidin-4-ylamino)-4-methoxy benzenesulfonamide as potent and selective 5-HT6 receptor (5-HT6R) antagonist with reasonable pharmacokinetic proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dec2f5c6b5293dce5b91a992b33543d
https://doi.org/10.1021/jm300955x
https://doi.org/10.1021/jm300955x
Autor:
Shinde Anil Karbhari, Narasimha Reddy G. Pamuleti, Kameswara Rao Karturi, Sobhanadri Arepalli, Ramasastri Kambhampati, Prabhakar Kothmirkar, Ramakrishna Nirogi, Amol D. Deshpande
Publikováno v:
Synthetic Communications. 38:2419-2428
A series of novel tetracyclic 6-thia-5a-aza-acephenanthrylene derivatives 7 were synthesized by rigidization of the arylsulfonyl/carbonyl/methyl moiety through C7 of indole, which was achieved under Heck conditions. The strategy of altering the palla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6c157816b3b0c8dedd0691785fd9d1a
https://doi.org/10.1080/00397910802139205
https://doi.org/10.1080/00397910802139205
Autor:
Ramakrishna Nirogi, Renny Abraham, Koteshwara Mudigonda, Kiran Kumar Penta, Santosh Kumar Pandey, Nageswararao Muddana, Ramasastri Kambhampati, Devender Reddy Ajjala, Rajesh Kumar Badange, Raghava Chowdary Palacharla, Vinod Kumar Goyal, Vijay Benade, Pradeep Jayarajan, Gopinadh Bhyrapuneni
Publikováno v:
Alzheimer's & Dementia. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbcbd95ef85d84875eeebde0b32aed33
https://doi.org/10.1016/j.jalz.2014.05.1484
https://doi.org/10.1016/j.jalz.2014.05.1484
Autor:
Ramakrishna, Nirogi, Anil, Shinde, Anand, Daulatabad, Ramasastri, Kambhampati, Parandhama, Gudla, Mohammad, Shaik, Muralimohan, Gampa, Suresh, Balasubramaniam, Pamuletinarasimhareddy, Gangadasari, Veena, Reballi, Rajeshkumar, Badange, Kumar, Bojja, Ramkumar, Subramanian, Gopinadh, Bhyrapuneni, Nageswararao, Muddana, Pradeep, Jayarajan
Publikováno v:
Journal of medicinal chemistry. 55(21)
Our initial findings around aryl sulfonamide series led to N-(3,5-dichloro-2-methoxyphenyl)-3-(1-methylpiperidin-4-ylamino)-4-methoxy benzenesulfonamide as potent and selective 5-HT(6) receptor (5-HT(6)R) antagonist with reasonable pharmacokinetic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::054e6f58a18c4c9104b7c7da7cac5301
https://pubmed.ncbi.nlm.nih.gov/23006002
https://pubmed.ncbi.nlm.nih.gov/23006002
Autor:
Ramakrishna V S, Nirogi, Rajeshkumar, Badange, Ramasastri, Kambhampati, Anil, Chindhe, Amol D, Deshpande, Vinaykumar, Tiriveedhi, Vishwottam, Kandikere, Nageswararao, Muddana, Renny, Abraham, Mukkanti, Khagga
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
4-(Piperazin-1-yl methyl)-N(1)-arylsulfonyl indole derivatives were designed and synthesized as 5-HT(6) receptor (5-HT(6)R) ligands. The lead compound 6a, from this series shows potent in vitro binding affinity, good PK profile, no CYP liabilities an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b7d49382f7f31d10609d963b717966a
https://pubmed.ncbi.nlm.nih.gov/23141912
https://pubmed.ncbi.nlm.nih.gov/23141912
Autor:
Saravana Kumar Marimuthu, Anil Shinde, Arunkumar Manoharan, Swayam Sampurna Mohanty, Rama Mohan Garikapati, Nageswararao Muddana, Mohammed Abdul Faheem, Abinash Das, Devender Reddy Ajjala, Shantaveer Irappanavar, Dhanalakshmi Shanmuganathan, Vishwottam Kandikere, Ramasastri Kambhampati, Venkat Reddy Mekala, Ramakrishna Nirogi, Amol D. Deshpande, Inderjeet Singh Bhatia, Kancharla Baburao, Ramoji Kosuru
Publikováno v:
Alzheimer's & Dementia. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb7bf4e815fe1616e0b1b70f62256fb
https://doi.org/10.1016/j.jalz.2012.05.1940
https://doi.org/10.1016/j.jalz.2012.05.1940
Autor:
Ramakrishna Nirogi, Arunkumar Manoharan, Renny Abraham, Abinash Das, Ramu Yaramasu, Gopinadh Bhyrapuneni, Vijay Benade, Adireddy Dwarampudi, Ramasastri Kambhampati, Shinde Anil Karbhari
Publikováno v:
Alzheimer's & Dementia. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::871decba266f99ac864d3f27d897f6c1
https://doi.org/10.1016/j.jalz.2012.05.543
https://doi.org/10.1016/j.jalz.2012.05.543
Autor:
Ramasastri Kambhampati, Pramod Kumar Dubey, Amol D. Deshpande, Parandhama Gudla, Sobhanadri Arepalli, Prabhakar Kothmirkar, Narasimhareddy P Gangadasari, Adireddy Dwarampudi, Anil Kashinath Chindhe, Ramakrishna Nirogi, Thrinath Reddy Bandyala, Jagadishbabu Konda, Shinde Anil Karbhari
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 27(3)
5-Hydroxytryptamine 6 receptors (5-HT(6)R) are being perceived as the possible target for treatment of cognitive disorders as well as obesity. The present article deals with the design, synthesis, in vitro binding and structure-activity relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20d84a9eb074e7f64e677a39055d803
https://pubmed.ncbi.nlm.nih.gov/21774748
https://pubmed.ncbi.nlm.nih.gov/21774748
Autor:
Ramasastri Kambhampati, Ramakrishna Nirogi, Vishwottam Kandikere, Vijay Benade, Shinde Anil Karbhari, Pradeep Jayarajan, Gopinadh Bhyrapuneni, Ramanatha Saralaya, Nageswararao Muddana, Mohamad Sadik Abdulhamid Mulla, Renny Abraham, Koteshwara Mudigonda
Publikováno v:
Alzheimer's & Dementia. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de5c5bd85b13507f510f05a00cfd9ca4
https://doi.org/10.1016/j.jalz.2011.05.1895
https://doi.org/10.1016/j.jalz.2011.05.1895