Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Ramasamy Thangavel"'
Autor:
Ramasamy Thangavel, Harleen Kaur, Iuliia Dubova, Govindhasamy Pushphavathi Selvakumar, Mohammad Ejaz Ahmed, Sudhanshu P. Raikwar, Raghav Govindarajan, Duraisamy Kempuraj
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1182 (2024)
Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease characterized by the presence of dopaminergic neuronal loss and motor disorders. PD dementia (PDD) is a cognitive disorder that affects many PD patients. We ha
Externí odkaz:
https://doaj.org/article/94b537a4ae19427ea2684e7cea633f52
Autor:
Duraisamy Kempuraj, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Ramasamy Thangavel, Sudhanshu P. Raikwar, Smita A. Zaheer, Shankar S. Iyer, Casey Burton, Donald James, Asgar Zaheer
Publikováno v:
Mediators of Inflammation, Vol 2020 (2020)
Traumatic brain injury (TBI) is one of the major health problems worldwide that causes death or permanent disability through primary and secondary damages in the brain. TBI causes primary brain damage and activates glial cells and immune and inflamma
Externí odkaz:
https://doaj.org/article/4cb671a6f59742f0b29426dde0a9bec7
Autor:
Duraisamy Kempuraj, Shireen Mentor, Ramasamy Thangavel, Mohammad E. Ahmed, Govindhasamy Pushpavathi Selvakumar, Sudhanshu P. Raikwar, Iuliia Dubova, Smita Zaheer, Shankar S. Iyer, Asgar Zaheer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Mast cell activation plays an important role in stress-mediated disease pathogenesis. Chronic stress cause or exacerbate aging and age-dependent neurodegenerative diseases. The severity of inflammatory diseases is worsened by the stress. Mast cell ac
Externí odkaz:
https://doaj.org/article/47a3aa91d7b045919e13565e7aaaa4ab
Autor:
Duraisamy Kempuraj, Govindhasamy P. Selvakumar, Ramasamy Thangavel, Mohammad E. Ahmed, Smita Zaheer, Sudhanshu P. Raikwar, Shankar S. Iyer, Sachin M. Bhagavan, Swathi Beladakere-Ramaswamy, Asgar Zaheer
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Mast cells are localized throughout the body and mediate allergic, immune, and inflammatory reactions. They are heterogeneous, tissue-resident, long-lived, and granulated cells. Mast cells increase their numbers in specific site in the body by prolif
Externí odkaz:
https://doaj.org/article/6439ff2046784dac99bf8271e1b0a755
Autor:
Duraisamy Kempuraj, Ramasamy Thangavel, Govindhasamy P. Selvakumar, Smita Zaheer, Mohammad E. Ahmed, Sudhanshu P. Raikwar, Haris Zahoor, Daniyal Saeed, Prashant A. Natteru, Shankar Iyer, Asgar Zaheer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Neuroinflammatory response is primarily a protective mechanism in the brain. However, excessive and chronic inflammatory responses can lead to deleterious effects involving immune cells, brain cells and signaling molecules. Neuroinflammation induces
Externí odkaz:
https://doaj.org/article/867524e3c7d14fab89a08e2f951b7e90
Autor:
Ramasamy Thangavel, Duraisamy Kempuraj, Smita Zaheer, Sudhanshu Raikwar, Mohammad E. Ahmed, Govindhasamy Pushpavathi Selvakumar, Shankar S. Iyer, Asgar Zaheer
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Alzheimer’s disease (AD) is characterized by the presence of neuropathological lesions containing amyloid plaques (APs) and neurofibrillary tangles (NFTs). AD is associated with mitochondrial dysfunctions, neuroinflammation and neurodegeneration in
Externí odkaz:
https://doaj.org/article/34fea704b36a43dbabddd8df922bbc4a
Autor:
Duraisamy Kempuraj, Ramasamy Thangavel, Evert Yang, Sagar Pattani, Smita Zaheer, Donna A Santillan, Mark K Santillan, Asgar Zaheer
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135776 (2015)
Parkinson's disease (PD) is characterized by the presence of Lewy bodies and degeneration of dopaminergic neurons. 1-methyl-4-phenylpyridinium (MPP+), a metabolite of neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Lewy body compon
Externí odkaz:
https://doaj.org/article/922a76609170484a88d0c36737bf1606
Akademický článek
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Autor:
Cameron Keomanivong, Josephine Schamp, Ervina Tabakovic, Ramasamy Thangavel, Georgina Aldridge, Andrew A. Pieper, Nandakumar S. Narayanan
Alpha-synuclein has been implicated in neurodegenerative diseases such as Parkinson’s disease and Dementia with Lewy bodies, with A53T and A30P mutations shown to be disease-causing. It has been reported that transgenic mice with tyrosine hydroxyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7437ee8f621a56964967a342b7fc1e0
https://doi.org/10.1101/2023.05.25.542172
https://doi.org/10.1101/2023.05.25.542172
Autor:
Matthew A. Weber, Gemma Kerr, Ramasamy Thangavel, Mackenzie M. Conlon, Hisham A. Abdelmotilib, Oday Halhouli, Qiang Zhang, Joel C. Geerling, Nandakumar S. Narayanan, Georgina M. Aldridge
Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are characterized by diffuse spread of alpha-synuclein (α-syn) throughout the brain. Patients with PDD and DLB have a neuropsychological pattern of deficits that include execut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33644b9267aaabb41c361a186af67389
https://doi.org/10.1101/2023.01.31.526365
https://doi.org/10.1101/2023.01.31.526365