Výsledky vyhledávání - "Ramar P. Samy"

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Data from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Metastatic breast cancer is still incurable so far; new specifically targeted and more effective therapies for triple-negative breast cancer (TNBC) are required in the clinic. In this study, our clinical data have established that basal and claudin-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19a0c0e006c3abbabd69d14315bda93e
https://doi.org/10.1158/1535-7163.c.6539263.v1

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Supplementary Figure 1 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 1: High ANXA1 and PPARγ expression levels positively correlates with the invasive, high-grade phenotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796a52bb0d216b583547635ad48b7918
https://doi.org/10.1158/1535-7163.22509319

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Supplementary Figure 2 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 2: ANXA1 expressing TNBC cell lines display greater sensitivity to PPARγ ligands compared to ANXA1 depleted cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48392110051076c68f80b12a3c9855ed
https://doi.org/10.1158/1535-7163.22509316

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Supplemental Data from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary methods and supplementary figure legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a6963a538aeeeffe32e7e217be5f31
https://doi.org/10.1158/1535-7163.22509322.v1

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Supplementary Figure 3 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 3: PPARγ induced expression of ANXA1 and cell death is abrogated in TNBC cells with pre-incubation of a PPARγ-specific antagonist or use of a dominant negative derivative of PPARγ.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0f8a276b53f71a91851a1a8a4f6ab9
https://doi.org/10.1158/1535-7163.22509313.v1

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Supplementary Figure 4 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 4: PPARγ ligand-induced changes in expression of RIP1 and NEMO and therefore NFκB activity are receptor dependent.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970d9325507dd54cc45444196a0bdeaf
https://doi.org/10.1158/1535-7163.22509310

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Akademický článek

Viperatoxin‐II: A novel viper venom protein as an effective bactericidal agent

Autor: Ramar Perumal Samy, Bradley G. Stiles, Arunachalam Chinnathambi, M.E. Zayed, Sulaiman Ali Alharbi, Octavio Luiz Franco, Edward G. Rowan, Alan Prem Kumar, Lina H.K. Lim, Gautam Sethi

Publikováno v: FEBS Open Bio, Vol 5, Iss 1, Pp 928-941 (2015)

Infections caused by methicillin‐resistant Staphylococcus aureus (MRSA) have become a rising threat to public health. There is an urgent need for development of promising new therapeutic agents against drug resistant bacteria like S. aureus. This r

Externí odkaz: https://doaj.org/article/8a859a51dc664bf191656a631d60c774

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Akademický článek

Melioidosis: Clinical impact and public health threat in the tropics.

Autor: Ramar Perumal Samy, Bradley G Stiles, Gautam Sethi, Lina H K Lim

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0004738 (2017)

This review briefly summarizes the geographical distribution and clinical impact of melioidosis, especially in the tropics. Burkholderia pseudomallei (a gram-negative bacterium) is the major causative agent for melioidosis, which is prevalent in Sing

Externí odkaz: https://doaj.org/article/a8e69e7f77684ecda070c11e0526b8a0

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