Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Ramanujam Rajagopalan"'
Autor:
Vivekanandhan Aravindhan, Viswanathan Mohan, Jayagopi Surendar, Maradana Muralidhara Rao, Nathella Pavankumar, Mohan Deepa, Ramanujam Rajagopalan, Vasanthapuram Kumaraswami, Thomas B Nutman, Subash Babu
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 6, p e707 (2010)
Epidemiological studies have shown an inverse correlation between the incidence of lymphatic filariasis (LF) and the incidence of allergies and autoimmunity. However, the interrelationship between LF and type-2 diabetes is not known and hence, a cros
Externí odkaz:
https://doaj.org/article/800a0700c74942a6998d07a5b7a38733
Autor:
Singh, Sunil Kumar, Vobbalareddy, Saibaba, Kalleda, Srinivasa Rao, Casturi, Seshagiri Rao, Datla, Srinivasa Raju, Mamidi, Rao N.V.S., Mullangi, Ramesh, Ramanujam, Rajagopalan, Yeleswarapu, Koteswar Rao, Iqbal, Javed
Publikováno v:
In Bioorganic & Medicinal Chemistry 2006 14(24):8626-8634
Autor:
K. Anantha Reddy, Ranjan Chakrabarti, V Balraju, Javed Iqbal, B. M. Rajesh, P. Bheema Rao, Gurram Ranga Madhavan, Ramanujam Rajagopalan
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:584-591
2,4-Thiazolidinedione derivatives of 1,3-benzoxazinone were synthesized and evaluated for their PPAR-α and -γ dual activation. DRF-2519, a compound obtained through SAR of TZD derivatives of benzoxazinone, has shown potent dual PPAR activation. In
Autor:
Jagattaran Das, Sreenivas Kandepu, Ramanujam Rajagopalan, N. Selvakumar, Sanjay Trehan, Mohammed A. Raheem, Trideep V. Rajale, Magadi Sitaram Kumar, Javed Iqbal, Manoj Kumar Khera
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4169-4172
The influence of an ethylene-oxy spacer element between the heterocycle and the aromatic ring in linezolid is reported. The introduction of such spacer group generated compounds with inferior antibacterial activity. However, the conversion of the ace
Autor:
P. Mahesh Kumar, R. Ajaya Kumar, Sriram Rajagopal, A. Venkateswarlu, Siva Sanjeeva Rao Thunuguntla, Dhanvanthri S. Deevi, Srinivas Nanduri, Sridevi Kasu, Vijay Kumar Nyavanandi, Ramanujam Rajagopalan, P. Sai Ram
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4111-4115
Azadirone 1, a limonoidal constituent of Azadirachta indica is found to possess potent cytotoxic activity against a panel of human cancer cell lines in our in vitro studies. In vitro screening of a number of semi-synthetic analogues of 1 revealed tha
Autor:
Cynthia Gershome, Ravi K.B. Damarla, Reeba K. Vikramadithyan, Juluri Suresh, Ramanujam Rajagopalan, Ranjan Chakrabarti, Jagadheshan Hiriyan, Parimal Misra, Suryaprakash Raichur
Publikováno v:
British Journal of Pharmacology. 140:527-537
Ragaglitazar [(−) DRF 2725; NNC 61-0029] is a coligand of PPARα and PPARγ. In ob/ob mice, ragaglitazar showed significant reduction in plasma glucose, triglyceride and insulin (ED50 values
Autor:
Chandrasekhar Venna, Ravikrishna Vallakati, Aravinda B. Pulipaka, Sriram Rajgopal, Vamsee Krishna Chintakunta, Manohar Sharma Vedula, Venkateswarlu Akella, Sravan Kumar Teepireddy, Ajaya Kumar Reka, Venkata Adiseshu Kattuboina, Akash Khandelwal, Ramanujam Rajagopalan, Sreenu Jinnapally, Vijay V. Upreti, Prem Kumar Mamnoor, Gopalakrishnan Bulusu, Vishnu Basetti, Srinivas Rao Mamidi
Publikováno v:
European Journal of Medicinal Chemistry. 38:811-824
New styryl sulfone compounds have been synthesized and evaluated for their anti-proliferative activity. Among the compounds synthesized, one compound ( 7k ) has shown 51% tumor growth inhibition in mice implanted with HT-29 human carcinoma at 400 mg
Autor:
V. Chandra Sekhar, N.V.S. Rao Mamidi, Ramanujam Rajagopalan, R. Ajaykumar, Sriram Rajagopal, K.V. Adi Seshu, Dhanvanthri S. Deevi, A. Venkateswarlu, P. Prasanna, C. Vamsee Krishna, Vedula Manohar Sharma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1679-1682
A series of 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues were synthesized and evaluated for cytotoxic activity against eight human cancer cell lines. Compounds 18 , 21 , 28 , 29 , 30 and 31 showed cytotoxic activity with GI 50 values
Autor:
Reeba K. Vikramadithyan, Ramanujam Rajagopalan, Juluri Suresh, Ravi K. Babu, Ranjan Chakrabarti, Cynthia Gershome, Parimal Misra, Jagadheshan Hiriyan
Publikováno v:
Obesity Research. 11:292-303
Objective: Preclinical evaluation of DRF 2655, a peroxisome proliferator-activated receptor alpha (PPARα) and PPARγ agonist, as a body-weight lowering, hypolipidemic and euglycemic agent. Research Methods and Procedures: DRF 2655 was studied in dif
Autor:
C.Seshagiri Rao, R. Ajaykumar, C.V. Laxman Rao, A. Venkateswarlu, P. Prasanna, K.B.Sunil Kumar, G. Sunil Kumar, Vedula Manohar Sharma, Dhanvanthri S. Deevi, K.V. Adi Seshu, Sriram Rajagopal, R.C. Puranik, P. Aravind Babu, Ramanujam Rajagopalan, B. Renuka, C. Prasad Narasimhulu, N.V.S. Rao Mamidi, D. Subramanyam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2303-2307
In our endeavor to design and synthesize novel anticancer agents, a new series of indoloquinazoline compounds were prepared and tested initially for anticancer activity in vitro against a panel of human cancer cell lines. Most of these compounds exhi