Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Ramanuj Achari"'
Autor:
Charles Locke, Keith Wesnes, Jun Zhang, David A. Katz, Ramanuj Achari, Katherine A. Tracy, Wei Liu
Publikováno v:
Alcoholism: Clinical and Experimental Research. 40:838-845
Background ABT-436, a potent and selective arginine vasopressin (AVP) type 1B receptor (V1B) antagonist, has previously demonstrated basal hypothalamic–pituitary–adrenal (HPA) axis attenuation in man. A V1B antagonist is hypothesized as an alcoho
Autor:
Maureen T. Kelly, Ramanuj Achari, H. Daniel Yannicelli, David A. Burt, Timi Edeki, Sarah M. Schweitzer, Linda E. Gustavson, Titus Chira, Matthew J. Rieser
Publikováno v:
Clinical Therapeutics. 28:373-387
This study was conducted to evaluate the potential for pharmacokinetic interaction between fenofibrate and ezetimibe in healthy subjects.This was a Phase I, open-label, multiple-dose,3-period crossover study conducted in healthy adult men and women.
Autor:
Linda E. Gustavson, H. Daniel Yannicelli, Ramanuj Achari, Hans-Ulrich Esslinger, Titus Chira, Sarah M. Schweitzer, Stephan Koehne-Voss
Publikováno v:
The Journal of Clinical Pharmacology. 45:947-953
Published data indicate that coadministration of multiple doses of the fibrate drug, gemfibrozil, led to a 202% increase in pravastatin systemic exposure (area under the plasma concentration-time curve, AUC). To evaluate the effects of another fibrat
Autor:
Robert O'Dea, Jenny Chan, Qin Ji, Rameshraja Palaparthy, Lewis B. Schwartz, Qiang Wang, Rajendra S. Pradhan, Ramanuj Achari, Titus Chira
Publikováno v:
Clinical Drug Investigation. 25:491-498
Objective: ABT-578, a tetrazole analogue of sirolimus (rapamycin), possesses anti-restenosis activity. The aim of this study was to assess the safety and pharmacokinetics of escalating single intravenous (IV) doses of ABT-578 in a phase 1, double-bli
Effect on bioavailability of admixing the contents of lansoprazole capsules with selected soft foods
Publikováno v:
Clinical Therapeutics. 22:231-236
Objective This study was designed to compare the bioavailability of lansoprazole when administered as an intact capsule and when the contents are admixed with various soft foods. Background Patients sometimes cannot swallow or have difficulty swallow
Autor:
Balakrishna Hosmane, Albert Cohen, Paul Linnen, Ramanuj Achari, John H. Cavanaugh, Paolo Baroldi
Publikováno v:
The Journal of Clinical Pharmacology. 38:545-553
Terazosin is a selective alpha1-adrenoceptor antagonist. A double-blind, randomized, placebo-controlled, two-period study evaluated the effects of posture and of oral and intravenous administration of terazosin on blood pressure and heart rate in pat
Publikováno v:
Southern Medical Journal. 85:3S-108
Autor:
Ramanuj Achari, Hao Xiong, Charles Locke, James R. Jankowski, Robert A. Carr, Darryl J. Sleep, Perry G. Wang, David A. Katz, Thao Doan
Publikováno v:
Journal of clinical pharmacology. 47(4)
The effect of rifampin, a cytochrome P450 3A4 inducer, on the pharmacokinetics of atrasentan was assessed in 12 healthy male subjects in an open-label study. Single doses of atrasentan 10 mg were administered orally on days 1 and 12. Rifampin 600 mg
Autor:
Yi-Lin Chiu, John H. Cavanaugh, Betsy L. Pilmer, Alexander H.C. Chun, Ramanuj Achari, Keith Erdman
Publikováno v:
Clinical therapeutics. 24(8)
Background: The ability to administer the contents of an encapsulated-dose formulation in liquids or soft foods without compromising drug bioavailability is highly desirable for patients who are unable to swallow or have difficulty swallowing. Object
Publikováno v:
Journal of clinical pharmacology. 40(10)
A double-blind, randomized, placebo-controlled, multicenter study was conducted to describe the dose-response curve for terazosin on blood pressure. A total of 128 patients with mild to moderate essential hypertension (supine diastolic blood pressure