Výsledky vyhledávání - "Ramanda Upshaw"

Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores

Autor: Raman Krishnan, Surendra K. Saini, Pooran Chand, Y. Sudhakar Babu, Scott R. Rowland, Shane Arnold, Yahya El-Kattan, Shanta Bantia, Pravin L. Kotian, Ramanda Upshaw

Publikováno v: Bioorganic & Medicinal Chemistry. 17:3934-3958

Factor VIIa (FVIIa), a serine protease enzyme, coupled with tissue factor (TF) plays an important role in a number of thrombosis-related disorders. Inhibition of TF x FVIIa occurs early in the coagulation cascade and might provide some safety advanta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e386f63754ff57584d80e442bafb2a54
https://doi.org/10.1016/j.bmc.2009.04.013

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The antithrombotic and anti-inflammatory effects of BCX-3607, a small molecule tissue factor/factor VIIa inhibitor

Autor: Hans Prydz, Pravin L. Kotian, C. Shane Arnold, Shanta Bantia, Cynthia Parker, Ramanda Upshaw, Pooran Chand, Y. Sudhakar Babu

Publikováno v: Thrombosis Research. 117:343-349

Tissue factor (TF) is a transmembrane glycoprotein that binds its zymogen cofactor, Factor VIIa (FVIIa) on the cell surface. Together (TF/FVIIa) they activate Factor X (FX) and Factor IX (FIX) and start the extrinsic pathway of blood coagulation. As

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68eb6cbb4650586797e205d06a5e0dbc
https://doi.org/10.1016/j.thromres.2005.03.015

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Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor—BCX-1777

Autor: Cynthia Parker, Ramanda Upshaw, Sandya L Ananth, Shanta Bantia, LaShun L Horn

Publikováno v: International Immunopharmacology. 3:879-887

Purine nucleoside phosphorylase (PNP) deficiency in humans produces a relatively selective depletion of T cells. BCX-1777 is a potent inhibitor of PNP. BCX-1777 in the presence of deoxyguanosine (dGuo) inhibits the proliferation of CEM-SS [T-acute ly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29de7264745b637b22074fd4930757ce
https://doi.org/10.1016/s1567-5769(03)00076-6

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Characterization of the binding affinities of peramivir and oseltamivir carboxylate to the neuraminidase enzyme

Autor: Shanta Bantia, Y.S. Babu, Ramanda Upshaw

Publikováno v: Antiviral research. 91(3)

With the continued threat of morbidity and mortality from influenza and the development of resistance to influenza antiviral drugs, there is increasing interest in new treatments, such as the investigational intravenous drug peramivir, and in combina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2207d6d6224721932231aba96479639
https://pubmed.ncbi.nlm.nih.gov/21722670

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Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes--a novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies

Autor: Cynthia Parker, Ramanda Upshaw, J. Michael Kilpatrick, Shanta Bantia, Yarlagadda S. Babu, Pravin L. Kotian, Amanda Cunningham, Pooran Chand, Philip E. Morris

Publikováno v: International immunopharmacology. 10(7)

The profound suppression of T-cell immunity seen in purine nucleoside phosphorylase (PNP; EC 2.4.2.1) deficient patients supports potential application of inhibitors of PNP in the therapy of T-cell mediated diseases. BCX-4208 is a novel potent transi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0f1dd842eabc14f312c0c641d1bb1c
https://pubmed.ncbi.nlm.nih.gov/20399911

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Anti-influenza virus activity of peramivir in mice with single intramuscular injection

Autor: Cynthia Parker, Ramanda Upshaw, C. Shane Arnold, Pooran Chand, Shanta Bantia

Publikováno v: Antiviral research. 69(1)

In the event of an influenza outbreak, antivirals including the neuraminidase (NA) inhibitors, peramivir, oseltamivir, and zanamivir may provide valuable benefit when vaccine production is delayed, limited, or cannot be used. Here we demonstrate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7804e94586f359f2b548447ec8be1b
https://pubmed.ncbi.nlm.nih.gov/16325932

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A Single Intramuscular Injection of Peramivir Demonstrates Anti-influenza Activity Against Recently Isolated Pandemic Flu Virus H1N1 (A/CA/04/2009)

Autor: Y.S. Babu, Debra Kellogg, Natalia A. Ilyushina, Mark N. Prichard, Cynthia Parker, Ramanda Upshaw, Shanta Bantia

Publikováno v: Antiviral Research. 86:A29-A30

Background: Peramivir is a potent and selective inhibitor of influenza neuraminidase. Here we demonstrate the efficacy of a single intramuscular (IM) injection of peramivir in mice infected with recently isolated pandemic flu virus H1N1 A/CA/04/09 (s

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https://doi.org/10.1016/j.antiviral.2010.02.361

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Corrigendum to 'Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores' [Bioorg. Med. Chem. 17 (2009) 3934]

Autor: Scott R. Rowland, Raman Krishnan, Pooran Chand, Shanta Bantia, Yahya El-Kattan, Y. Sudhakar Babu, Surendra K. Saini, Ramanda Upshaw, Pravin L. Kotian, Shane Arnold

Publikováno v: Bioorganic & Medicinal Chemistry. 18:460

Corrigendum to ‘‘Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores” [Bioorg. Med. Chem. 17 (2009) 3934] Pravin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::291efc17a5428569f6e1ba88c61f6d76
https://doi.org/10.1016/j.bmc.2009.11.041

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BCX-4208 (RO5092888), a Purine Nucleoside Phosphorylase (PNP) Inhibitor, Is a Novel, Potent Orally Active Anti-T-Cell and B-Cell Agent

Autor: Cynthia Parker, Ramanda Upshaw, J. M. Kilpatrick, Shanta Bantia, Jianwen Zhang, Philip E. Morris, Pooran Chand, Amanda Cunningham, Yarlagadda S. Babu, Pravin L. Kotian

Publikováno v: Blood. 112:1547-1547

The profound suppression of T-cell immunity seen in patients with an inherited PNP deficiency supports the potential application of inhibitors of this purine salvage enzyme in the therapy of T-cell malignancies and T-cell mediated autoimmune diseases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33347a366ca99fdc8a1dde7378d70343
https://doi.org/10.1182/blood.v112.11.1547.1547

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