Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ramanavelan Sakthivel"'
Autor:
Matthew Esparza, Amir Mor, Hanspeter Niederstrasser, Kris White, Alexander White, Ke Zhang, Shengyan Gao, Juan Wang, Jue Liang, Sei Sho, Ramanavelan Sakthivel, Adwait A Sathe, Chao Xing, Raquel Muñoz-Moreno, Jerry W Shay, Adolfo García-Sastre, Joseph Ready, Bruce Posner, Beatriz M A Fontoura
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008407 (2020)
Influenza A viruses are human pathogens with limited therapeutic options. Therefore, it is crucial to devise strategies for the identification of new classes of antiviral medications. The influenza A virus genome is constituted of 8 RNA segments. Two
Externí odkaz:
https://doaj.org/article/773ab3005ec64c18aba2b674724f2b62
Autor:
Sharon K Kuss-Duerkop, Juan Wang, Ignacio Mena, Kris White, Giorgi Metreveli, Ramanavelan Sakthivel, Miguel A Mata, Raquel Muñoz-Moreno, Xiang Chen, Florian Krammer, Michael S Diamond, Zhijian J Chen, Adolfo García-Sastre, Beatriz M A Fontoura
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006635 (2017)
Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility. While the role of mTORC1 in viral infection has been studied, the mechanisms that induce
Externí odkaz:
https://doaj.org/article/e5701111c937410e8f04ce085979868f
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005370 (2016)
Plasmodium salivary sporozoites are the infectious form of the malaria parasite and are dormant inside salivary glands of Anopheles mosquitoes. During dormancy, protein translation is inhibited by the kinase UIS1 that phosphorylates serine 59 in the
Externí odkaz:
https://doaj.org/article/5c286e91b5884ad1b411d611436fcfcc
Autor:
Hanspeter Niederstrasser, Chao Xing, Ramanavelan Sakthivel, Juan Wang, Alexander D. White, Joseph M. Ready, Sei Sho, Matthew Esparza, Amir Mor, Jerry W. Shay, Kris M. White, Adolfo García-Sastre, Adwait Amod Sathe, Jue Liang, Ke Zhang, Beatriz M. A. Fontoura, Bruce A. Posner, Shengyan Gao, Raquel Muñoz-Moreno
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008407 (2020)
PLoS Pathogens
PLoS Pathogens
Influenza A viruses are human pathogens with limited therapeutic options. Therefore, it is crucial to devise strategies for the identification of new classes of antiviral medications. The influenza A virus genome is constituted of 8 RNA segments. Two
Autor:
Min Kim, Dandan Shao, Beatriz M. A. Fontoura, Ramanavelan Sakthivel, Wei Mo, Liang Zhang, Nicholas K. Conrad, Juan Wang, Adolfo García-Sastre, Aparna Anantharaman, Raquel Muñoz-Moreno
Publikováno v:
Journal of Virology. 92
The NS1 protein of influenza A virus is a multifunctional virulence factor that inhibits cellular processes to facilitate viral gene expression. While NS1 is known to interact with RNA and proteins to execute these functions, the cellular RNAs that p
Autor:
Kristen W. Lynch, Matthew G. Thompson, Abhilash Padavannil, Yuh Min Chook, Zhijian J. Chen, Ramanavelan Sakthivel, Min Kim, Guijun Shang, Adolfo García-Sastre, Ke Zhang, Juan Wang, Xiang Chen, Beatriz M. A. Fontoura
The influenza virulence factor NS1 protein interacts with the cellular NS1-BP protein to promote splicing and nuclear export of the viral M mRNAs. The viral M1 mRNA encodes the M1 matrix protein and is alternatively spliced into the M2 mRNA, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ddd36f0401aa9f0bdd6025cf3b0acf
https://europepmc.org/articles/PMC6310826/
https://europepmc.org/articles/PMC6310826/
Autor:
Kris M. White, Beatriz M. A. Fontoura, Florian Krammer, Sharon K. Kuss-Duerkop, Giorgi Metreveli, Michael S. Diamond, Ignacio Mena, Miguel A. Mata, Raquel Muñoz-Moreno, Juan Wang, Xiang Chen, Ramanavelan Sakthivel, Zhijian J. Chen, Adolfo García-Sastre
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006635 (2017)
PLoS Pathogens
PLoS Pathogens
Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility. While the role of mTORC1 in viral infection has been studied, the mechanisms that induce
Publikováno v:
Traffic
Trafficking of proteins and RNA into and out of the nucleus occurs through the nuclear pore complex (NPC). Due to its critical function in many cellular processes, the NPC and transport factors are common targets of several viruses that disrupt key c
Autor:
Satish Mishra, Victor Nussenzweig, Margarito Rojas, Beatriz M. A. Fontoura, William J. Sullivan, Robert Ménard, Thomas E. Dever, Ravikant Ranjan, Ramanavelan Sakthivel, Min Zhang
Publikováno v:
Proceedings of the National Academy of Sciences. 109:3956-3961
In response to environmental stresses, the mammalian serine threonine kinases PERK, GCN2, HRI, and PKR phosphorylate the regulatory serine 51 of the eukaryotic translation initiation factor 2α (eIF2α) to inhibit global protein synthesis. Plasmodium
Autor:
John M. Shelton, Joachim Seemann, Daniel R. Nussenzveig, Bandarigoda N. Somatilaka, Liang Zhang, Sharon K. Kuss, Beatriz M. A. Fontoura, Ramanavelan Sakthivel, Amnon Harel, Jue Yang, Thais Garcias Moreira, Lihi Shaulov, Ana Maria Caetano Faria, Jessica S. Williams
Publikováno v:
Scientific Reports
The Sec13 protein functions in various intracellular compartments including the nuclear pore complex, COPII-coated vesicles and inside the nucleus as a transcription regulator. Here we developed a mouse model that expresses low levels of Sec13 (Sec13