Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Ramanathan Karuppasamy"'
Publikováno v:
Frontiers in Physics, Vol 12 (2024)
Somatic transformations in the key catalytic residues of the Isocitrate Dehydrogenase (IDH) enzyme assist in the onset of distinct malignancies including glioma. Currently, enasidenib is the FDA-approved drug used to target IDH2 protein. However, the
Externí odkaz:
https://doaj.org/article/5d68f3800dbc4cf892b877bafae04df3
Autor:
Akachukwu Ibezim, Mbanefo S. Madukaife, Sochi C. Osigwe, Nadja Engel, Ramanathan Karuppasamy, Fidele Ntie-Kang
Publikováno v:
BMC Chemistry, Vol 16, Iss 1, Pp 1-9 (2022)
Abstract Type III beta phosphatidylinositol 4-kinase (PI4KIIIβ) is the only clinically validated drug target in Plasmodium kinases and therefore a critical target in developing novel drugs for malaria. Current PI4KIIIβ inhibitors have solubility an
Externí odkaz:
https://doaj.org/article/6a6ea292690840adaf99867b801cc5f7
Publikováno v:
Vaccines, Vol 11, Iss 3, p 577 (2023)
Immunotherapy is emerging as a potential therapeutic strategy for triple negative breast cancer (TNBC) owing to the immunogenic landscape of its tumor microenvironment. Interestingly, peptide-based cancer vaccines have garnered a lot of attention as
Externí odkaz:
https://doaj.org/article/64d0d36703af4247936be8dc3e6ca214
Autor:
Ajitha Antony, Ramanathan Karuppasamy
Publikováno v:
Agronomy, Vol 12, Iss 7, p 1635 (2022)
Weed management is the major biological constraint in paddy (Oryza sativa L.) producing areas. Predominantly, barnyard grass (Echinochloa crus-galli) is a rice-mimicking weed that causes 57% of yield loss in rice production. Conventionally, herbicide
Externí odkaz:
https://doaj.org/article/aec6a8b43ef54c43a080fbea28e7ad93
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 59 (2021)
The RAS–RAF–MEK–ERK pathway plays a key role in malevolent cell progression in many tumors. The high structural complexity in the upstream kinases limits the treatment progress. Thus, MEK inhibition is a promising strategy since it is easy to i
Externí odkaz:
https://doaj.org/article/fa447e4ff71c4a698f361ec749a6aaa5
Autor:
Ibezim, Akachukwu, Onah, Emmanuel, Osigwe, Sochi Chinaemerem, Okoroafor, Peter Ukwu, Ukoha, Onyeoziri Pius, de Siqueira-Neto, Jair Lage, Ntie-Kang, Fidele, Ramanathan, Karuppasamy
Publikováno v:
In Scientific African June 2024 24
Autor:
Teja, Chitrala1 (AUTHOR), Ramanathan, Karuppasamy2 (AUTHOR), Naresh, Kondapalli3 (AUTHOR), Vidya, R.4 (AUTHOR), Gomathi, K.5 (AUTHOR), Nawaz, Fazlur Rahman1 (AUTHOR)
Publikováno v:
Polycyclic Aromatic Compounds. 2023, Vol. 43 Issue 1, p874-894. 21p.
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 23:1085-1101
Background: Targeting mutated isocitrate dehydrogenase 1 (mIDH1) is one of the key therapeutic strategies for the treatment of glioma. Few inhibitors, such as ivosidenib and vorasidenib, have been identified as selective inhibitors of mIDH1. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af029e9aca2f14b1b8a5183ccc25cc48
https://doi.org/10.2174/1871520623666230125090815
https://doi.org/10.2174/1871520623666230125090815
Autor:
Ajitha Antony, Ramanathan Karuppasamy
Publikováno v:
Paddy and Water Environment. 21:231-242
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e26e314b14ee16d914f86ada6be7dbd7
https://doi.org/10.1007/s10333-023-00924-y
https://doi.org/10.1007/s10333-023-00924-y
Autor:
Ajitha Antony, Ramanathan Karuppasamy
Publikováno v:
Natural Product Research. :1-5
Paddy (Oryza sativa) yield is greatly influenced by the insidious presence of rice-mimicking weed, widely known as barnyard grass. This study explores the promising natural ACCase inhibitors that could enhance paddy yield by controlling weeds. A tota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72c1f2a44c570d2a45634d790447d2e
https://doi.org/10.1080/14786419.2022.2152449
https://doi.org/10.1080/14786419.2022.2152449