Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ramanatha Saralaya"'
Autor:
Manoranjan Panda, Anandkumar Raichurkar, Neela Dinesh, Vinayak Hosagrahara, Naveen Kumar, K.R. Prabhakar, Suresh Rudrapatna, Gayathri Balakrishnan, Amit K. Gupta, Vasan K. Sambandamurthy, Karthikeyan Kandaswamy, Stefan Kavanagh, Ramanatha Saralaya, Lalit kumar Jena, Shridhar Narayanan, Suresh Solapure, Robert Nanduri, V. Balasubramanian, Meenakshi Mallya, Ashwini Narayan, Sowmya Bharath, Vijender Panduga, Vikas Shinde, Jitendar Reddy, Khisi Mdluili, Christopher B. Cooper, Parvinder Kaur, Shahul Hameed P, Sreevalli Sharma, Supreeth Guptha, Kakoli Mukherjee, Sudha Ravishankar, Radha Shandil, Pravin Iyer, Shankar D. Markad, Vasanthi Ramachandran, Takahiro Yano, Jyothi Bhat, Harvey Rubin, Subramanyam J. Tantry
Publikováno v:
MedChemComm. 7:1022-1032
The success of bedaquiline as an anti-tubercular agent for the treatment of multidrug-resistant tuberculosis has validated the ATP synthesis pathway and in particular ATP synthase as an attractive target. However, limitations associated with its use
Autor:
Swaminathan Rajagopalan, Jitendar Reddy, Vijender Panduga, K.R. Prabhakar, Naveen Kumar, Anand Anandkumar, Ragini Singh, Vasanthi Ramachandran, Swati Khandelwal, Santanu Datta, Narasimha Rao, Shridhar Narayanan, Suresh Solapure, Malancha Karmarkar, Radha Shandil, V. Balasubramanian, Ramanatha Saralaya, Robert Nanduri, Sreevalli Sharma
Publikováno v:
Antimicrobial Agents and Chemotherapy
There are currently 18 drug classes for the treatment of tuberculosis, including those in the development pipeline. An in silico simulation enabled combing the innumerably large search space to derive multidrug combinations. Through the use of ordina
Autor:
Nageswararao Muddana, Renny Abraham, Gopinadh Bhyrapuneni, Ramakrishna Nirogi, Vishwottam Kandikere, Pradeep Jayarajan, Ramanatha Saralaya
Publikováno v:
The American Journal of Drug and Alcohol Abuse. 39:72-79
Background: Epidemiologic studies and clinical assessment of schizophrenic population have revealed a high incidence of overlap between schizophrenia and addictive disorders. Objective: The aim of the present investigation was to study the effect of
Autor:
Abhishek Srivastava, Vijender Panduga, Ramanatha Saralaya, Prabhakar K. R., Shahul Hameed, Suresh Solapure, Vinayak P. Hosagrahara
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 47(11)
1. During the course of metabolic profiling of lead Compound 1, glutathione (GSH) conjugates were detected in rat bile, suggesting the formation of reactive intermediate precursor(s). This was confirmed by the identification of GSH and N-acetylcystei
Autor:
Vishwottam Kandikere, Ramanatha Saralaya, Prashanth Komarneni, Nageswararao Muddana, Koteshwara Mudigonda, Ramakrishna Nirogi, Gopinadh Bhyrapuneni, K. Mukkanti
Publikováno v:
Biopharmaceutics & Drug Disposition. 33:265-277
During pregnancy, the disposition of various drugs is altered due to changes in physiological condition, maternal gastrointestinal absorption, gastric secretion and motility. A fixed dose combination of antiretrovirals is commonly prescribed for the
Autor:
Gopinadh Bhyrapuneni, Devender Reddy Ajjala, Vishwottam Kandikere, Ramakrishna Nirogi, Nageswararao Muddana, Ramanatha Saralaya
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 65:136-141
Introduction In vivo brain receptor occupancy has been the key assay in driving preclinical drug discovery program and there is a need to hasten this screening step. Radiolabeled methods, which are time consuming and expensive, are most widely employ
Autor:
Gopinadh Bhyrapuneni, Ramakrishna Nirogi, Arun Kumar Manoharan, Nageswararao Muddana, Ranjith Kumar Ponnamaneni, Ramanatha Saralaya, Vishwottam Kandikere
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 65:115-121
Introduction Rapid and reliable preclinical receptor occupancy measurement at the target organ in relevant species is critical in accelerating the drug hunting process. The aim of this study was to develop in vivo receptor occupancy assay for histami
Autor:
Vijay Benade, Nageswararao Muddana, Ramanatha Saralaya, Vishwottam Kandikere, Gopinadh Bhyrapuneni, Ramakrishna V. S. Nirogi, Koteshwara Mudigonda
Publikováno v:
Journal of Neuroscience Methods. 178:116-119
Many central nervous system (CNS) drug discovery programs require the successful collection of cerebrospinal fluid (CSF) for assessing CNS penetration and distribution of new chemical entities. The objective of the present investigation was to simpli
Autor:
Shridhar Narayanan, Laura M. Sanz, Sreenivasaiah Menasinakai, Kevin Hickling, Abhishek Srivastava, Sapna Morayya, Anandkumar Raichurkar, Vikas Patil, Stefan Kavanagh, María Belén Jiménez-Díaz, Ramanatha Saralaya, Vijender Panduga, Gajanan Shanbag, Eknath V. Bellale, Lyn Rosenbrier-Ribeiro, K.R. Prabhakar, Anisha Ambady, David Waterson, Nikhil Rautela, Kannan Murugan, Pavithra Viswanath, Peter Warner, Pamela Magistrado, Pravin Iyer, Dyann F. Wirth, Jayashree Puttur, Krishna Koushik, Sowmya Bharath, Nilanjana Roy Choudhury, Philipp P. Henrich, Olivia Coburn-Flynn, Suresh Solapure, Radha Nandishaiah, Balachandra Bandodkar, Kakoli Mukherjee, María Santos Martínez, Suresh Rudrapatna, David A. Fidock, Shahul Hameed P, Vinayak Hosagrahara, Monalisa Chatterji, Vasan K. Sambandamurthy, V. Balasubramanian, Sudhir Landge, Jitendar Reddy, Robert E. McLaughlin, Amanda K. Lukens, Adam Jeston Dudley, Disha Awasthy
Publikováno v:
Nature Communications
The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery and optimization of novel antimalarial compounds,
Autor:
Adedayo Adedoyin, Elizabeth G. Rhee, Bernardino Mosquera, Jan J. De Waele, David P. Nicolau, Elaine Gadzicki, Zhen Zeng, Luzelena Caro, Ramanatha Saralaya, Kajal B. Larson, Joseph L. Kuti
Publikováno v:
Open Forum Infectious Diseases. 4:S543-S543