Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Ramanarayanan Krishnamurthy"'
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103283- (2024)
Summary: Cyclic-phospholipids-based vesicles can play a role in facilitating the chemical evolution of protocells from the structurally simple to the functionally more complex form. Here, we present a protocol for preparing decanoic acid-derived cycl
Externí odkaz:
https://doaj.org/article/f4e8a8ade7de4a0aad48f1fbe37d4cd3
Autor:
Ruiqin Yi, Mike Mojica, Albert C. Fahrenbach, H. James Cleaves, Ramanarayanan Krishnamurthy, Charles L. Liotta
Publikováno v:
JACS Au, Vol 3, Iss 9, Pp 2522-2535 (2023)
Externí odkaz:
https://doaj.org/article/8147ac21d06645e68c32dd7ab2372775
Publikováno v:
Life, Vol 13, Iss 4, p 920 (2023)
The in-fall of meteorites and interstellar dust particles during the Hadean–Archean heavy bombardment may have provided the early Earth with various reduced oxidation state phosphorus compounds and minerals, including phosphite (HPO32−)([Pi(III)]
Externí odkaz:
https://doaj.org/article/ca8390cdd3c14a3f847cf56a1271bca2
Autor:
Moran Frenkel-Pinter, Jay W. Haynes, Ahmad M. Mohyeldin, Martin C, Alyssa B. Sargon, Anton S. Petrov, Ramanarayanan Krishnamurthy, Nicholas V. Hud, Loren Dean Williams, Luke J. Leman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Cooperative relationships are widespread among different classes of biopolymers and are predicted to have existed during emergence of life. This study shows that proto-peptides engage in mutually stabilizing interactions with RNA, providing support f
Externí odkaz:
https://doaj.org/article/ce86f8db408449cc807579afb0ac893f
Autor:
Greg Springsteen, Jayasudhan Reddy Yerabolu, Julia Nelson, Chandler Joel Rhea, Ramanarayanan Krishnamurthy
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The citric acid cycle (TCA) is a fundamental metabolic pathway to release stored energy in living organisms. Here, the authors report two linked cycles of reactions that each oxidize glyoxylate into CO2 and generate intermediates shared with the mode
Externí odkaz:
https://doaj.org/article/1e6144bbca0e42bb8932fe4c609492ca
Autor:
Ramanarayanan Krishnamurthy
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-3 (2018)
Abstract There are varied views about how the molecules of life may have appeared on early Earth. Nowhere is this divergence more acute than in the origins of DNA/RNA and has become a matter of constant deliberations.
Externí odkaz:
https://doaj.org/article/be1f85ae4fc34017aecd1be583097b57
Publikováno v:
SynOpen, Vol 01, Iss 01, Pp 0029-0040 (2017)
Abstract The reactivity of trifluoromethanesulfonyl esters derived from l-lyxofuranosides and l-lyxopyranosides was investigated with various 5-aminopyrimidines as nucleophiles with the expectation to synthesize N-substituted 5-amino-ribosugars. The
Externí odkaz:
https://doaj.org/article/20176fceeae14d17b68f02f233111b06
Autor:
Brian J. Cafferty, David M. Fialho, Jaheda Khanam, Ramanarayanan Krishnamurthy, Nicholas V. Hud
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
One of the questions for prebiotic chemistry is the formation of complementary base pairing systems. Here, the authors show that plausible two prebiotic heterocycles can form glycosidic bonds with ribose in water and that these spontaneously base-pai
Externí odkaz:
https://doaj.org/article/929a087411554bbb88a0d9e551908211
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 2131-2138 (2014)
IsoGNA, an isomer of glycerol nucleic acid GNA, is a flexible (acyclic) nucleic acid with bases directly attached to its linear backbone. IsoGNA exhibits (limited) base-pairing properties which are unique compared to other known flexible nucleic acid
Externí odkaz:
https://doaj.org/article/f742e959dd234d438e1135187a2ba93f
Publikováno v:
Life, Vol 7, Iss 3, p 32 (2017)
Phosphorylation under plausible prebiotic conditions continues to be one of the defining issues for the role of phosphorus in the origins of life processes. In this review, we cover the reactions of alternative forms of phosphate, specifically the ni
Externí odkaz:
https://doaj.org/article/60cdc2345e3242fab4fb14771a35031f