Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Raman Mahadevan Iyer"'
Autor:
Vesna Petrovska Jovanovska, Tilen Huzjak, Raman Mahadevan Iyer, Manuel Sanchez-Felix, Miha Jaklič, Cornelius Harlacher, Katja Berginc, Flavio Fabiani
Publikováno v:
Pharmaceutics
Volume 13
Issue 10
Pharmaceutics, Vol 13, Iss 1682, p 1682 (2021)
Volume 13
Issue 10
Pharmaceutics, Vol 13, Iss 1682, p 1682 (2021)
Poorly water-soluble drugs pose a significant challenge to developability due to poor oral absorption leading to poor bioavailability. Several approaches exist that improve the oral absorption of such compounds by enhancing the aqueous solubility and
Autor:
Navnit Hargovindas Shah, Raman Mahadevan Iyer, Harpreet K. Sandhu, Fumie Tanno, Ashish L. Sarode, Sakae Obara
Publikováno v:
Carbohydrate Polymers. 101:146-153
HPMCAS is a widely used polymer in the pharmaceutical industry as an excipient. In this work, the physicochemical stability of HPMCAS was investigated for hot melt extrusion (HME) application. The reduction in zero rate viscosity (η0) of the polymer
Autor:
Gregory E. Amidon, James DiNunzio, A. W. Malick, Raman Mahadevan Iyer, Dharmendra Singhal, Yu E. Zhang, Shridhar Hegde
Publikováno v:
Journal of Pharmaceutical Sciences. 102:3604-3613
The impact of melt extrusion (HME) and spray drying (SD) on mechanical properties of hypromellose acetate succinate (HPMCAS), copovidone, and their formulated blends was studied and compared with that of reference excipients. Tensile strength (TS), c
Publikováno v:
Pharmaceutical Development and Technology. 19:577-582
Material properties play a significant role in pharmaceutical processing. In the present study, a novel approach is used to determine solid fraction (SF) based on a direct measurement (DM) of the apparent volume of a sample. The sample was scanned wi
Autor:
Harpreet K. Sandhu, Rina J. Chokshi, A. Waseem Malick, Navnit Hargovindas Shah, Raman Mahadevan Iyer, Hossein Zia
Publikováno v:
Journal of Pharmaceutical Sciences. 94:2463-2474
The objective of the study was to characterize the physical and viscoelastic properties of binary mixtures of drug and selected polymers to assess their suitability for use in the hot-melt extrusion (HME) process as a means to improve solubility by m
Autor:
Hitesh Chokshi, Sandhu Harpreet K, Navnit Hargovindas Shah, Duk Soon Choi, Raman Mahadevan Iyer, A. Waseem Malick
Publikováno v:
Advances in Delivery Science and Technology ISBN: 9781493915972
Since the first application of microprecipitation process to manufacture amorphous solid dispersions a decade ago, microprecipitated bulk powder (MBP) technology has been applied to a number of poorly soluble compounds to enhance their biopharmaceuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::779ad36823737717b7a7a0f574eabf06
https://doi.org/10.1007/978-1-4939-1598-9_12
https://doi.org/10.1007/978-1-4939-1598-9_12
Autor:
Navnit Hargovindas Shah, Raman Mahadevan Iyer, A. Waseem Malick, Sandhu Harpreet K, Hitesh Chokshi, Duk Soon Choi
Publikováno v:
Advances in Delivery Science and Technology ISBN: 9781493915972
An increasing number of poorly soluble drugs emerging from discovery organizations is a major challenge for drug development. Formulation approaches such as particle size reduction, use of solubilizers, and complexing agents, in addition to lipid for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::322c2aa532b6991cdf550b009b39053e
https://doi.org/10.1007/978-1-4939-1598-9_10
https://doi.org/10.1007/978-1-4939-1598-9_10
Publikováno v:
Pharmaceutical development and technology. 19(5)
Material properties play a significant role in pharmaceutical processing. The impact of roller compaction (RC) and tablet compression on solid fraction (SF), tensile strength (TS) and flexural modulus (FM) of Avicel DG [co-processed excipient with 75
Autor:
Hans-Juergen Mair, Joseph F. Grippo, Hitesh Chokshi, Prabha N. Ibrahim, Karsten Fähnrich, Hung Tian, Linda Rubia, James Mouskountakis, K. Tang, Theresa Louie, Harpreet K. Sandhu, Zenaida Go, Waseem Malick, Anni Pabst-Ravot, Emmanuel Scheubel, Duk Soon Choi, Sebastian Moreira, Navnit Hargovindas Shah, Raman Mahadevan Iyer, Ralph Diodone, Dharmendra Singhal
Publikováno v:
Journal of pharmaceutical sciences. 102(3)
The present work deals with improving the solubility of vemurafenib, a practically insoluble drug, by converting it into an amorphous-solid dispersion using a solvent-controlled precipitation process. The dispersion containing vemurafenib and hyprome
Autor:
Wantanee Phuapradit, Albano Antonio A, Duk Soon Choi, Hung Tian, Harpreet K. Sandhu, Shalini Anand, Navnit Hargovindas Shah, K. Tang, Rodolfo Pinal, Raman Mahadevan Iyer, Ashish Chatterji, Hitesh Chokshi, Waseem Malick, Dharmendra Singhal
Publikováno v:
International journal of pharmaceutics. 438(1-2)
A novel method was developed to manufacture amorphous formulations of poorly soluble compounds that cannot be processed with existing methods such as spray drying and melt extrusion. The manufacturing process and the characterization of the resulting