Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Raman, Devarajan"'
Autor:
Sara P. Cruz, Qin Zhang, Raman Devarajan, Christos Paia, Binjie Luo, Kai Zhang, Saara Koivusalo, Longguang Qin, Jihan Xia, Anne Ahtikoski, Markku Vaarala, Tomasz Wenta, Gong‐Hong Wei, Aki Manninen
Publikováno v:
Advanced Science, Vol 11, Iss 11, Pp n/a-n/a (2024)
Abstract The extracellular matrix (ECM) undergoes substantial changes during prostate cancer (PCa) progression, thereby regulating PCa growth and invasion. Herein, a meta‐analysis of multiple PCa cohorts is performed which revealed that downregulat
Externí odkaz:
https://doaj.org/article/8122d00339f94410a874a0dfe4629d49
Autor:
Xiayun Yang, Qin Zhang, Shuxuan Li, Raman Devarajan, Binjie Luo, Zenglai Tan, Zixian Wang, Nikolaos Giannareas, Tomasz Wenta, Wenlong Ma, Yuqing Li, Yuehong Yang, Aki Manninen, Song Wu, Gong-Hong Wei
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-30 (2023)
Abstract Background Aberrant somatic genomic alteration including copy number amplification is a hallmark of cancer genomes. We previously profiled genomic landscapes of prostate cancer (PCa), yet the underlying causal genes with prognostic potential
Externí odkaz:
https://doaj.org/article/5ac07c8f5fb64b55b03685f77c3dbda4
Autor:
Raman Devarajan, Valerio Izzi, Hellevi Peltoketo, Gunilla Rask, Saila Kauppila, Marja-Riitta Väisänen, Heli Ruotsalainen, Guillermo Martínez-Nieto, Sanna-Maria Karppinen, Timo Väisänen, Inderjeet Kaur, Jussi Koivunen, Takako Sasaki, Robert Winqvist, Aki Manninen, Fredrik Wärnberg, Malin Sund, Taina Pihlajaniemi, Ritva Heljasvaara
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
The tumor extracellular matrix (ECM) critically regulates cancer progression and treatment response. Expression of the basement membrane component collagen XVIII (ColXVIII) is induced in solid tumors, but its involvement in tumorigenesis has remained
Externí odkaz:
https://doaj.org/article/e957e170320b4816a30b9afccd36d3ca
Autor:
Guillermo A. Martínez-Nieto, Hanna-Riikka Teppo, Noora Petrelius, Valerio Izzi, Raman Devarajan, Tiina Petäistö, Hengshuo Liu, Kris S. Kim, Sanna-Maria Karppinen, Heli Ruotsalainen, Jarkko Koivunen, Joni M. Mäki, Gilbert C. Walker, Taina Pihlajaniemi, Donald Gullberg, Ritva Heljasvaara
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing. The expression of the α11 is upregulated in cancer-associated fibroblasts (CAFs) in vario
Externí odkaz:
https://doaj.org/article/a42f98c2b506481b89f70daf56c95400
Autor:
Valerio Izzi, Juho Lakkala, Raman Devarajan, Eeva-Riitta Savolainen, Pirjo Koistinen, Ritva Heljasvaara, Taina Pihlajaniemi
Publikováno v:
Leukemia Research Reports, Vol 9, Iss , Pp 9-13 (2018)
Relapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet b
Externí odkaz:
https://doaj.org/article/9859af782f3b48f3aa892fb6e672708a
Autor:
Guillermo Martínez-Nieto, Ritva Heljasvaara, Anne Heikkinen, Hanne-Kaisa Kaski, Raman Devarajan, Otto Rinne, Charlotta Henriksson, Emmi Thomson, Camilla von Hertzen, Ilkka Miinalainen, Heli Ruotsalainen, Taina Pihlajaniemi, Sanna-Maria Karppinen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9978 (2021)
Basement membrane (BM) zone-associated collagen XV (ColXV) has been shown to suppress the malignancy of tumour cells, and its restin domain can inhibit angiogenesis. In human breast cancer, as well as in many other human carcinomas, ColXV is lost fro
Externí odkaz:
https://doaj.org/article/ed07102488da46b6bfacad73bf12acf6
Autor:
Valerio Izzi, Juho Lakkala, Raman Devarajan, Anni Kääriäinen, Jarkko Koivunen, Ritva Heljasvaara, Taina Pihlajaniemi
Publikováno v:
Matrix Biology Plus, Vol 1, Iss , Pp - (2019)
The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines and growth factors collectively referred to as the matrisome. Stud
Externí odkaz:
https://doaj.org/article/fe32c318bc4f4fda961b345e4f936469
Autor:
Lauri Eklund, Harri Elamaa, Taina Pihlajaniemi, Lloyd Ruddock, Gong-Hong Wei, Qin Zhang, Mohammadhassan Ansarizadeh, Anna Laitakari, Ilkka Miinalainen, Raman Devarajan, Anne Heikkinen, Hongmin Tu, Veli-Pekka Ronkainen, Mika Kaakinen, Riikka Pietilä, Minna K. Kihlström, Emmi Kapiainen
Visualization of basal cell surface of ANGPT2-GFP HUVECs during cell spreading.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cec62beb0505fbc1725b2ab10c1d54c
https://doi.org/10.1158/0008-5472.22426509
https://doi.org/10.1158/0008-5472.22426509
Autor:
Lauri Eklund, Harri Elamaa, Taina Pihlajaniemi, Lloyd Ruddock, Gong-Hong Wei, Qin Zhang, Mohammadhassan Ansarizadeh, Anna Laitakari, Ilkka Miinalainen, Raman Devarajan, Anne Heikkinen, Hongmin Tu, Veli-Pekka Ronkainen, Mika Kaakinen, Riikka Pietilä, Minna K. Kihlström, Emmi Kapiainen
Supplementary Figure S1: Amino acid sequence of ANGPT2, ANGPT2443 and ANGTPT2DAP. Supplementary Figure S2: Competitive inhibition of ANGPT4-induced TIE2 phosphorylation by ANGPT2 isoforms. Supplementary Figure S3. TIE2 phosphorylation by ANGPT2 isofo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48eb29cab98bf33eb845539dd7992c3f
https://doi.org/10.1158/0008-5472.22426518
https://doi.org/10.1158/0008-5472.22426518
Autor:
Lauri Eklund, Harri Elamaa, Taina Pihlajaniemi, Lloyd Ruddock, Gong-Hong Wei, Qin Zhang, Mohammadhassan Ansarizadeh, Anna Laitakari, Ilkka Miinalainen, Raman Devarajan, Anne Heikkinen, Hongmin Tu, Veli-Pekka Ronkainen, Mika Kaakinen, Riikka Pietilä, Minna K. Kihlström, Emmi Kapiainen
Angiopoietin-2 (ANGPT2) is a context-dependent TIE2 agonistic or antagonistic ligand that induces diverse responses in cancer. Blocking ANGPT2 provides a promising strategy for inhibiting tumor growth and metastasis, yet variable effects of targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11b00faa0ce8b7dc41393cd27efe7e1
https://doi.org/10.1158/0008-5472.c.6512358.v1
https://doi.org/10.1158/0008-5472.c.6512358.v1