Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ramakrishnan B Kumar"'
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0228607 (2020)
Among the first steps in inflammation is the conversion of arachidonic acid (AA) stored in the cell membranes into leukotrienes. This occurs mainly in leukocytes and depends on the interaction of two proteins: 5-lipoxygenase (5LO), stored away from t
Externí odkaz:
https://doaj.org/article/729de061a73a4fb58f7621a68ae22da2
Autor:
Ramakrishnan B Kumar, Lin Zhu, Helena Idborg, Olof Rådmark, Per-Johan Jakobsson, Agnes Rinaldo-Matthis, Hans Hebert, Caroline Jegerschöld
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152116 (2016)
An important step in the production of inflammatory mediators of the leukotriene family is the Ca2+ mediated recruitment of 5 Lipoxygenase (5LO) to nuclear membranes. To study this reaction in vitro, the natural membrane mimicking environment of nano
Externí odkaz:
https://doaj.org/article/755a0776bee44b2f8363b8b7efc427c3
Increased intracellular water content defined as cytotoxic brain tissue edema is a serious secondary clinical complication to traumatic brain injury (TBI) and stroke and without knowledge to the etiology. Recently a hypothesis to the nervous tissue e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99033920fc09ea56490c4b2e37a274e3
https://doi.org/10.9734/bpi/nfmmr/v15/4002f
https://doi.org/10.9734/bpi/nfmmr/v15/4002f
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0228607 (2020)
PLoS ONE, Vol 15, Iss 7, p e0228607 (2020)
Among the first steps in inflammation is the conversion of arachidonic acid (AA) stored in the cell membranes into leukotrienes. This occurs mainly in leukocytes and depends on the interaction of two proteins: 5-lipoxygenase (5LO), stored away from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea40c76e0214ef42eeba7a2f65abd826
https://pubmed.ncbi.nlm.nih.gov/32645009
https://pubmed.ncbi.nlm.nih.gov/32645009
Publikováno v:
Journal of Neurology and Neurobiology. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c88d0cf9e25c95a5eb8f743d4521cf7
https://doi.org/10.16966/2379-7150.154
https://doi.org/10.16966/2379-7150.154
Publikováno v:
Journal of Neurology and Neurobiology. 4
Increased intracellular water content defined as cytotoxic brain tissue edema is a serious secondary clinical complication to traumatic brain injury (TBI) and stroke and without knowledge to the et ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39010d274bc92f3a3612b4c80a619985
https://doi.org/10.16966/2379-7150.151
https://doi.org/10.16966/2379-7150.151
Monotopic proteins exert their function when attached to a membrane surface, and such interactions depend on the specific lipid composition and on the availability of enough area to perform the function. Nanodiscs are used to provide a membrane surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ac4b9daefb79130995238731ddc2c0
https://europepmc.org/articles/PMC5409284/
https://europepmc.org/articles/PMC5409284/
Autor:
Ramakrishnan B. Kumar, Mahmudul Hasan, Jesper Z. Haeggström, Fredrik Tholander, Damian Niegowski, Alena Stsiapanava, Abdul Aziz Qureshi, Marjolein M. G. M. Thunnissen, Agnes Rinaldo-Matthis
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1844:439-446
Leukotriene A4 hydrolase/aminopeptidase (LTA4H) (EC 3.3.2.6) is a bifunctional zinc metalloenzyme with both an epoxide hydrolase and an aminopeptidase activity. LTA4H from the African claw toad, Xenopus laevis (xlLTA4H) has been shown to, unlike the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d78745e2ee454966217bbc9980644b
https://doi.org/10.1016/j.bbapap.2013.12.003
https://doi.org/10.1016/j.bbapap.2013.12.003
Autor:
Ramakrishnan B. Kumar, Monica Mittal, Caroline Jegerschöld, Agnes Rinaldo-Matthis, Navisraj Balagunaseelan, Olof Rådmark, Mats Hamberg, Jesper Z. Haeggström
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(15)
Human 5-lipoxygenase (5-LOX) is responsible for the formation of leukotriene (LT)A4, a pivotal intermediate in the biosynthesis of the leukotrienes, a family of proinflammatory lipid mediators. 5-LOX has thus gained attention as a potential drug targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd3131945f115cb78ea38f066c9c890
https://pubmed.ncbi.nlm.nih.gov/27363940
https://pubmed.ncbi.nlm.nih.gov/27363940
Autor:
Ramakrishnan B. Kumar, Olof Rådmark, Lin Zhu, Hans Hebert, Agnes Rinaldo-Matthis, Helena Idborg, Per-Johan Jakobsson, Caroline Jegerschöld
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 3, p e0152116 (2016)
PLoS ONE, Vol 11, Iss 3, p e0152116 (2016)
An important step in the production of inflammatory mediators of the leukotriene family is the Ca2+ mediated recruitment of 5 Lipoxygenase (5LO) to nuclear membranes. To study this reaction in vitro, the natural membrane mimicking environment of nano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559fd67320a87cfd8451b79b640ccbf5
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-185630
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-185630