Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ramakrishna Boyanapalli"'
Autor:
Nenad Svrzikapa, Kenneth A. Longo, Nripesh Prasad, Ramakrishna Boyanapalli, Jeffrey M. Brown, Daniel Dorset, Scott Yourstone, Jason Powers, Shawn E. Levy, Aaron J. Morris, Chandra Vargeese, Jaya Goyal
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 162-173 (2020)
Novel treatments for Huntington’s disease (HD), a progressive neurodegenerative disorder, include selective targeting of the mutant allele of the huntingtin gene (mHTT) carrying the abnormally expanded disease-causing cytosine-adenine-guanine (CAG)
Externí odkaz:
https://doaj.org/article/65d1f0e1bbb64c3b9d640e8783a84fb1
Publikováno v:
Methods in Molecular Biology ISBN: 9781071628188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4501be382191c8794f91c5b8facf59cc
https://doi.org/10.1007/978-1-0716-2819-5_3
https://doi.org/10.1007/978-1-0716-2819-5_3
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2590
Haplotyping individual full-length transcripts can be important in diagnosis and treatment of certain genetic diseases. One set of diseases, repeat expansions of simple tandem repeat sequences are the cause of over 40 neurological disorders. In many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b57f9a822087e8977e0af286aeeb4e9
https://pubmed.ncbi.nlm.nih.gov/36335491
https://pubmed.ncbi.nlm.nih.gov/36335491
Publikováno v:
Nucleic acid therapeutics. 32(4)
As oligonucleotides (ONs) and similar nucleic acid therapeutic modalities enter development pipelines, there is continual need to develop bioanalytical methodologies addressing unique challenges they pose. Novel ONs back bone chemistries, especially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143763d7f74626ddf78b38dc7951b1c5
https://pubmed.ncbi.nlm.nih.gov/35404142
https://pubmed.ncbi.nlm.nih.gov/35404142
Autor:
Daniel Dorset, Ramakrishna Boyanapalli, Kenneth Longo, Jeffrey M. Brown, Aaron J. Morris, Nripesh Prasad, Scott Yourstone, Shawn Levy, Chandra Vargeese, Nenad Svrzikapa, Jaya Goyal, Jason Powers
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 162-173 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 162-173 (2020)
Novel treatments for Huntington’s disease (HD), a progressive neurodegenerative disorder, include selective targeting of the mutant allele of the huntingtin gene (mHTT) carrying the abnormally expanded disease-causing cytosine-adenine-guanine (CAG)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a876e8e2835d79e2bba28b9a1adca6
http://europepmc.org/articles/PMC7648085
http://europepmc.org/articles/PMC7648085
Publikováno v:
An Introduction to Bioanalysis of Biopharmaceuticals ISBN: 9783030971922
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b38f9b9d37c56814ba5412682bea30e
https://doi.org/10.1007/978-3-030-97193-9_6
https://doi.org/10.1007/978-3-030-97193-9_6
Publikováno v:
An Introduction to Bioanalysis of Biopharmaceuticals ISBN: 9783030971922
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05fd6355a6a41e2c844dc7ca96e6787b
https://doi.org/10.1007/978-3-030-97193-9_5
https://doi.org/10.1007/978-3-030-97193-9_5
Autor:
Katherine M, Wilson, Eszter, Katona, Idoia, Glaria, Mireia, Carcolé, Imogen J, Swift, Aitana, Sogorb-Esteve, Carolin, Heller, Arabella, Bouzigues, Amanda J, Heslegrave, Ashvini, Keshavan, Kathryn, Knowles, Saurabh, Patil, Susovan, Mohapatra, Yuanjing, Liu, Jaya, Goyal, Raquel, Sanchez-Valle, Robert Jr, Laforce, Matthis, Synofzik, James B, Rowe, Elizabeth, Finger, Rik, Vandenberghe, Christopher R, Butler, Alexander, Gerhard, John C, Van Swieten, Harro, Seelaar, Barbara, Borroni, Daniela, Galimberti, Alexandre, de Mendonça, Mario, Masellis, M Carmela, Tartaglia, Markus, Otto, Caroline, Graff, Simon, Ducharme, Jonathan M, Schott, Andrea, Malaspina, Henrik, Zetterberg, Ramakrishna, Boyanapalli, Jonathan D, Rohrer, Adrian M, Isaacs, Miren, Zulaica
Publikováno v:
Journal of neurology, neurosurgery, and psychiatry. 93(7)
A GGGGCC repeat expansion in theWe used the single molecule array (Simoa) platform to develop an immunoassay for measuring poly(GP) dipeptide repeat proteins (DPRs) generated by theWe show the assay to be highly sensitive and robust, passing extensiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79bb98e10e36c5abc2fb0ed5ebeebce1
https://pubmed.ncbi.nlm.nih.gov/35379698
https://pubmed.ncbi.nlm.nih.gov/35379698
Autor:
Katherine M Wilson, Eszter Katona, Idoia Glaria, Imogen J. Swift, Aitana Sogorb-Esteve, Carolin Heller, Arabella Bouzigues, Amanda J Heslegrave, Saurabh Patil, Susovan Mohapatra, Yuanjing Liu, Jaya Goyal, Raquel Sanchez-Valle, Robert Laforce, Matthis Synofzik, James B. Rowe, Elizabeth Finger, Rik Vandenberghe, Chris R. Butler, Alexander Gerhard, John van Swieten, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Alexandre de Mendonça, Mario Masellis, Carmela Tartaglia, Markus Otto, Caroline Graff, Simon Ducharme, Andrea Malaspina, Henrik Zetterberg, Ramakrishna Boyanapalli, Jonathan D Rohrer, Adrian M Isaacs
A GGGGCC repeat expansion in the C9orf72 gene is the most common cause of genetic frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). As potential therapies targeting the repeat expansion are now entering clinical trials, sensitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e289e4539d4eed389e07eae029a4847
https://doi.org/10.1101/2021.12.14.21267456
https://doi.org/10.1101/2021.12.14.21267456
Autor:
Vissia Viglietta, Xiao Shelley Hu, Danlin Xu, Stephen Lake, Elena Dale, Michael Panzara, Kenechi Ejebe, Ramakrishna Boyanapalli
Publikováno v:
F: Clinical studies: case reports, observational studies and trials.
Background Huntington’s disease is caused by the expansion of CAG-repeats (≥36 repeats) in at least one copy of HTT gene that leads to the expression of mutant HTT (mHTT) protein. The unaffected copy of HTT gene encodes wild-type HTT (wtHTT) prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21b17d0a05850b6273e924dc546f2be1
https://doi.org/10.1136/jnnp-2021-ehdn.82
https://doi.org/10.1136/jnnp-2021-ehdn.82