Výsledky vyhledávání - "Ramakanth Madhugiri"

Akademický článek

Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5′-termini of RNA and polymerase function

Autor: Lu Liu, Ramakanth Madhugiri, Vera Vivian Saul, Susanne Bacher, Michael Kracht, Stephan Pleschka, M. Lienhard Schmitz

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract The influenza A virus (IAV) polymerase is a multifunctional machine that can adopt alternative configurations to perform transcription and replication of the viral RNA genome in a temporally ordered manner. Although the structure of polymera

Externí odkaz: https://doaj.org/article/617e46c449cd43499e62b64a037f70f4

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Akademický článek

Rocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity

Autor: Wiebke Obermann, Alexandra Friedrich, Ramakanth Madhugiri, Paul Klemm, Jan Philipp Mengel, Torsten Hain, Stephan Pleschka, Hans-Guido Wendel, Roland K. Hartmann, Susanne Schiffmann, John Ziebuhr, Christin Müller, Arnold Grünweller

Publikováno v: Viruses, Vol 14, Iss 3, p 519 (2022)

Rocaglates are potent broad-spectrum antiviral compounds with a promising safety profile. They inhibit viral protein synthesis for different RNA viruses by clamping the 5′-UTRs of mRNAs onto the surface of the RNA helicase eIF4A. Apart from the nat

Externí odkaz: https://doaj.org/article/3e1d33eeeca54b6b86b42b72458da6f7

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Akademický článek

Ultra deep sequencing of Listeria monocytogenes sRNA transcriptome revealed new antisense RNAs.

Autor: Sebastian Behrens, Stefanie Widder, Gopala Krishna Mannala, Xiaoxing Qing, Ramakanth Madhugiri, Nathalie Kefer, Mobarak Abu Mraheil, Thomas Rattei, Torsten Hain

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e83979 (2014)

Listeria monocytogenes, a gram-positive pathogen, and causative agent of listeriosis, has become a widely used model organism for intracellular infections. Recent studies have identified small non-coding RNAs (sRNAs) as important factors for regulati

Externí odkaz: https://doaj.org/article/d86299b15ccf4e7dbbdba50434b523f4

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Akademický článek

Detection of very long antisense transcripts by whole transcriptome RNA-Seq analysis of Listeria monocytogenes by semiconductor sequencing technology.

Autor: Stefanie Wehner, Gopala K Mannala, Xiaoxing Qing, Ramakanth Madhugiri, Trinad Chakraborty, Mobarak A Mraheil, Torsten Hain, Manja Marz

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e108639 (2014)

The Gram-positive bacterium Listeria monocytogenes is the causative agent of listeriosis, a severe food-borne infection characterised by abortion, septicaemia, or meningoencephalitis. L. monocytogenes causes outbreaks of febrile gastroenteritis and a

Externí odkaz: https://doaj.org/article/e57dace0b0d94d3a9dc1a28ed05013b9

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Conserved Characteristics of NMPylation Activities of Alpha- and Betacoronavirus NiRAN Domains

Autor: Heiko Slanina, Ramakanth Madhugiri, Kai Wenk, Tess Reinke, Karin Schultheiß, Julia Schultheis, Nadja Karl, Uwe Linne, John Ziebuhr

Publikováno v: Journal of Virology.

There is strong evidence that coronaviruses and other large nidoviruses evolved a number of unique enzymatic activities, including an additional RdRp-associated NiRAN domain, that are conserved in nidoviruses but not in most other RNA viruses. Previo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8622f48fbbe5f39fe653d22ec024894
https://doi.org/10.1128/jvi.00465-23

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sRNA-mediated RNA processing regulates bacterial cell division

Autor: Julian, Grützner, Bernhard, Remes, Katrin M H, Eisenhardt, Daniel, Scheller, Jonas, Kretz, Ramakanth, Madhugiri, Matthew, McIntosh, Gabriele, Klug

Publikováno v: Nucleic Acids Research

Tight control of cell division is essential for survival of most organisms. For prokaryotes, the regulatory mechanisms involved in the control of cell division are mostly unknown. We show that the small non-coding sRNA StsR has an important role in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e374c0d4955b6094b364c3d7715c00d1
https://pubmed.ncbi.nlm.nih.gov/34125915

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Hallmarks of Alpha- And Betacoronavirus non-structural protein 7+8 complexes

Autor: Dmitri I. Svergun, John Ziebuhr, Kristina Lorenzen, Boris Krichel, Renato Zenobi, Martin Koehler, Clement E. Blanchet, Robin Schubert, Charlotte Uetrecht, Ramakanth Madhugiri, L. Brings, Ganesh Bylapudi, C. Schmidt

Publikováno v: Science Advances, 7 (10)
Science Advances
bioRxiv
article-version (status) pre
article-version (number) 2
Science advances 7(10), eabf1004 (1-15) (2021). doi:10.1126/sciadv.abf1004

Coronaviral nsp7+8 complexes follow species- and stoichiometry-specific assembly pathways determined by few amino acid changes.
Coronaviruses infect many different species including humans. The last two decades have seen three zoonotic coronavir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c368da939228739887e5639c8f871ea8
https://hdl.handle.net/20.500.11850/474238

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Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2

Autor: Christoph A. Sotriffer, Ramakanth Madhugiri, Collin Zimmer, John Ziebuhr, Stefan Hammerschmidt, Armin Welker, Patrick Müller, Hannah Maus, Robert A. Zimmermann, Christian Kersten, Tanja Schirmeister, Christin Müller

Publikováno v: ChemMedChem
Chemmedchem

Inhibition of coronavirus (CoV)‐encoded papain‐like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure‐activity relationships (SAR) of the noncovale

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627c491608d91a712d1a845443b3f44e
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/22570

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Characterization of a bafinivirus exoribonuclease activity

Autor: John Ziebuhr, Marc Sauerwald, Ramakanth Madhugiri, Izabela Durzynska, Nadja Karl

Publikováno v: Journal of General Virology. 99:1253-1260

White bream virus (WBV), a poorly characterized plus-strand RNA virus infecting freshwater fish of the Cyprinidae family, is the prototype species of the genus Bafinivirus in the subfamily Torovirinae (family Coronaviridae, order Nidovirales). In com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7dd8af4f7b5d84ee36fa2b30bd800cd
https://doi.org/10.1099/jgv.0.001120

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