Zobrazeno 1 - 10 of 77 pro vyhledávání: '"Ramaiah Muthyala"'
1
Akademický článek
Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action
Autor: Jozafina Milicaj, Bakar A. Hassan, Joy M. Cote, Carlos A. Ramirez-Mondragon, Nadiya Jaunbocus, Angelika Rafalowski, Kaelan R. Patel, Colleen D. Castro, Ramaiah Muthyala, Yuk Y. Sham, Erika A. Taylor
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract A clinically relevant inhibitor for Heptosyltransferase I (HepI) has been sought after for many years because of its critical role in the biosynthesis of lipopolysaccharides on bacterial cell surfaces. While many labs have discovered or desi
Externí odkaz: https://doaj.org/article/bcc4b0c42cce4877be0993ff4f99cb78
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2
Akademický článek
Modeling and Simulation of hGAT1: A Mechanistic Investigation of the GABA Transport Process
Autor: Sadia Zafar, Megin E. Nguyen, Ramaiah Muthyala, Ishrat Jabeen, Yuk Y. Sham
Publikováno v: Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 61-69 (2019)
Human γ-Aminobutyric acid transporter 1 (hGAT1) is a Na+/Cl− dependent co-transporter that plays a key role in the inhibitory neurotransmission of GABA in the brain. Due to the lack of structural data, the exact co-transport mechanism of GABA reup
Externí odkaz: https://doaj.org/article/76f687969bee42a0a4cedc0e4253a178
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4
Akademický článek
Conserved Conformational Hierarchy across Functionally Divergent Glycosyltransferases of the GT-B Structural Superfamily as Determined from Microsecond Molecular Dynamics
Autor: Carlos A. Ramirez-Mondragon, Megin E. Nguyen, Jozafina Milicaj, Bakar A. Hassan, Frank J. Tucci, Ramaiah Muthyala, Jiali Gao, Erika A. Taylor, Yuk Y. Sham
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 9, p 4619 (2021)
It has long been understood that some proteins undergo conformational transitions en route to the Michaelis Complex to allow chemistry. Examination of crystal structures of glycosyltransferase enzymes in the GT-B structural class reveals that the pre
Externí odkaz: https://doaj.org/article/1686a2140c5044349958c396a17e8907
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6
Akademický článek
Concise total synthesis of cytotoxic natural products (+) and (-)-muricatacin
Autor: Srinivasarao Yaragorla, Ramaiah Muthyala
Publikováno v: ARKIVOC, Vol 2010, Iss 10, Pp 178-184 (2010)
Externí odkaz: https://doaj.org/article/8d4963501cce4896a243b40aefb1fbaa
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7
Discovery of Aminoglycosides as first in class, nanomolar inhibitors of Heptosyltransferase I
Autor: Bakar A. Hassan, Erika A. Taylor, Kaelan R Patel, Colleen D. Castro, Joy M. Cote, Yuk Y. Sham, Jozafina Milicaj, Angelika Rafalowski, Ramaiah Muthyala, Carlos A. Ramirez-Mondragon, Nadiya A. Jaunbocus
A clinically relevant inhibitor for Heptosyltransferase I (HepI) has been sought after for many years and while many have designed novel small-molecule inhibitors, these compounds lack the bioavailability and potency necessary for therapeutic use. Ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ede2e5e7bf25c056769cacb0d177914
https://doi.org/10.1101/2021.10.03.462930
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8
Conserved conformational hierarchy across functionally divergent glycosyltransferases of the GT-B structural superfamily as determined from microsecond molecular dynamics
Autor: Jozafina Milicaj, Ramaiah Muthyala, Yuk Y. Sham, Carlos A. Ramirez-Mondragon, Frank J. Tucci, Erika A. Taylor, Megin E. Nguyen
It has long been understood that some proteins to undergo conformational transitions enroute to the Michaelis Complex to allow chemistry. Examination of crystal structures of glycosyltransferase enzymes in the GT-B structural class reveals that the p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3b534259b0618d30eee3e9d40fcada6
https://doi.org/10.1101/2020.07.02.181073
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9
Akademický článek
Glycerol monolaurate and dodecylglycerol effects on Staphylococcus aureus and toxic shock syndrome toxin-1 in vitro and in vivo.
Autor: Ying-Chi Lin, Patrick M Schlievert, Michele J Anderson, Christina L Fair, Matthew M Schaefers, Ramaiah Muthyala, Marnie L Peterson
Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7499 (2009)
BACKGROUND:Glycerol monolaurate (GML), a 12 carbon fatty acid monoester, inhibits Staphylococcus aureus growth and exotoxin production, but is degraded by S. aureus lipase. Therefore, dodecylglycerol (DDG), a 12 carbon fatty acid monoether, was compa
Externí odkaz: https://doaj.org/article/0a288341e3f94592822e84aa11e8d95a
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