Výsledky vyhledávání - "Ramaglia, M."

Effetti e meccanismi molecolari della Curcumina nelle leucemie linfoblasti che acute dell’età pediatrica

Autor: D’Angelo, V., PICA, ALESSANDRA, Iannotta, A., Di Massa, L., Ramaglia, M., Tirino, V., Di Martino, M., Pota, E., Di Pinto, D., Boccieri, E., MANCA, ROSA, Perrotta, S., Indolfi, P., Casale, F. .

La curcumina, componente della curcuma presente nei rizomi della Curcuma Longa, sembra avere effetti antineoplastici per cui è stata studiata quale potenziale agente per la prevenzione e il trattamento di varie neoplasie in quanto bloccherebbe la tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::8cf95775d0e34f39980495fb6f3fcade
http://hdl.handle.net/11588/678191

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Enhancer Role of rMnSOD in apoptosis triggering by daunorubicin of pediatric B-ALL cells

Autor: Casale, F., D’Angelo, V., PICA, ALESSANDRA, Iannotta, A., Ramaglia, M., Di Massa, L., POLLIO, MARIA LAURA, MANCA, ROSA, Di Martino, M., Oreste, M., Mancini, A, Borrelli, A, Indolfi, P.

Background/Objectives Leukemic cells produce higher amounts of ROS than healthy cells and express low levels of antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD). Recently, it was demonstrated that rMnSOD, a recombinant new is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::68d0ec65aa1df2818710b45f7dbf4a0e
http://hdl.handle.net/11588/678192

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Effect of rMnSOD on survival signaling in pediatric high risk T-cell acute lymphoblastic leukaemia

Autor: Pica, A, Di Santi, A, D'ANGELO, Velia, Iannotta, A, Ramaglia, M, Di Martino, M, Pollio, M. L, Schiattarella, A, Borrelli, A, Mancini, A, INDOLFI, Paolo, CASALE, Fiorina

Publikováno v: Journal of cellular physiology. 230(5)

Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that defends against oxidative damage due to reactive oxygen species (ROS). A new isoform of MnSOD with cytotoxic activity was recently discovered in liposarcoma cells. Here, we tested

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::75285d8048743609233c0b05c0433f62
https://pubmed.ncbi.nlm.nih.gov/25294747

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Influence of methylenetetrahydrofolate reductase gene polymorphisms on the outcome of pediatric patients with non-Hodgkin lymphoma treated with high-dose methotrexate

Autor: D'ANGELO, Velia, Ramaglia M, Iannotta A, Francese M, Pota E, Affinita MC, Pecoraro G, Indolfi C, Di Martino M, Di Pinto D, Buffardi S, Poggi V, Indolfi P, CASALE, Fiorina

"High-dose methotrexate (MTX) is a key component of most treatment protocols for childhood and adolescent non-Hodgkin lymphoma (NHL). Recent studies have suggested that the toxicity of antifolate drugs, such as MTX, is affected by inherited single nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3977::70e6f12d2ceacb5f56b1b0cea746eadb
http://hdl.handle.net/11591/321116

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Role of pro survival signaling proteins in high-risk pediatric leukemic cells following rMnSOD treatment

Autor: IANNOTTA A, D’ANGELO V, RAMAGLIA M., A. BORRELLI, A. SCHIATTARELLA, A. MANCINI, INDOLFI P., CASALE F., DI SANTI, ANNALISA, BASILE, FILOMENA, PICA, ALESSANDRA

Purpose: The subgroup of High-risk acute lymphoblastic leukemia (ALL) remains one of the greatest challenges in pediatric oncology. Current treatments are still based on chemotherapy whose mechanism of action is non specific and which has a narrow th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::ca09543d13b96fec703ecb7f2cb115ab
http://hdl.handle.net/11588/399383

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