Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Ramachandran S. Ranganathan"'
1
New Multimeric Magnetic Resonance Imaging Agents
Autor: Sang Kang, Xun Zhang, Ramachandran S. Ranganathan, Maria Fernandez, K. M. R. Pillai, Peter C. Ratsep, Michael F. Tweedle, Adrian D. Nunn
Publikováno v: Investigative Radiology. 33:779-797
The authors investigated the effect of multimerization on the relaxivity of macrocyclic gadolinium (Gd) chelates. The objective was to develop more sensitive magnetic resonance imaging (MRI) contrast agents to study biochemical processes.Covalently l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec110fb1022e8fa4f52bbbb9b2169edf
https://doi.org/10.1097/00004424-199811000-00002
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2
Heterocyclic nonionic X-ray contrast agents V: A facile conversion of 2-tetrahydrofuroamides into α-hydroxy-δ-valerolactams and a general synthesis of lactams conjugated to 2,4,6-triiodoisophthalamides
Autor: K. Natalie, Hong Fan, C.-K. Chen, Thangavel Arunachalam, T. R. Wagler, R. Neubeck, Edmund R. Marinelli, N. Soundararajan, K. M. R. Pillai, Ramachandran S. Ranganathan, J. Emswiler, G. Diamantidis
Publikováno v: Tetrahedron. 52:11177-11214
The synthesis of 2,4,6-triiodoisophthalamides substituted by a lactam moiety is described. A tandem ring opening-ring closure methodology consisting of a regiospecific ether cleavage of the tetrahydrofuroanilide 14b , followed by lactamization to α-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d723932a097f4094862f711aaee7b3a
https://doi.org/10.1016/0040-4020(96)00668-0
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3
Design of conformationally rigid dimeric MRI agents
Autor: Shukla R, Pillai Radhakrishna, Ratsep Pc, Ramachandran S. Ranganathan, Michael F. Tweedle, Zhang X, Maria Fernandez
Publikováno v: Magnetic Resonance in Medicine. 35:928-931
The conformational flexibility of the linkage mechanism or tether between paramagnetic metal centers is explored to assess optimal structural characteristics of multimeric MRI contrast agents. Two dimeric paramagnetic chelates differing in linkage fl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd066593521092c1dc103e6afcd31d9
https://doi.org/10.1002/mrm.1910350623
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7
Polymethylated DOTA ligands. 1. Synthesis of rigidified ligands and studies on the effects of alkyl substitution on acid-base properties and conformational mobility
Autor: Jean F. Desreux, Radhakrishna Pillai, Hanh Nguyen, Ramachandran S. Ranganathan, Michael F. Tweedle, Natarajan Raju, Helen Fan, Vincent Jacques
Publikováno v: Inorganic chemistry. 41(25)
This work describes the synthesis and the conformational properties of new polymethylated macrocyclic ligands of potential interest for magnetic resonance imaging. M4cyclen, (2S,5S,8S,11S)-2,5,8,11-tetramethyl-1,4,7,10-tetraazacyclododecane, was obta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ad0a6aa0c469db94253aaaac8aa232
https://pubmed.ncbi.nlm.nih.gov/12470083
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8
Polymethylated DOTA ligands. 2. Synthesis of rigidified lanthanide chelates and studies on the effect of alkyl substitution on conformational mobility and relaxivity
Autor: Helen Fan, Ramachandran S. Ranganathan, Jean F. Desreux, Natarajan Raju, Michael F. Tweedle, Vincent Jacques, Xun Zhang
Publikováno v: Inorganic chemistry. 41(25)
M4DOTA, [(2S,5S,8S,11S)-4,7,10-tris-carboxymethyl-2,5,8,11-tetramethyl-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid (2e), and M4DOTMA, (R)-2-[(2S,5S,8S,11S)-4,7,10-tris-((R)-1-carboxyethyl)-2,5,8,11-tetramethyl-1,4,7,10-tetraazacyclododecan-1-yl]pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68035f72787b960fe6086eacc59b04f5
https://pubmed.ncbi.nlm.nih.gov/12470084
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