The haematopoietic potential of human amniotic fluid stem cells

Autor: Ramachandra, Durrgah Latchumi

There is a constant demand for haematopoietic stem cells (HSC) for clinical applications. Amniotic fluid stem (AFS) cells serve as a potential autologous cell source for therapy. Previously murine and sheep AFS have shown to have significant haematop

Externí odkaz: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.747120

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In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanised Mouse Model and Its Progress Can Be Monitored Using MRI Techniques

Autor: Shangaris, Panicos, Loukogeorgakis, Stavros P., Subramaniam, Sindhu, Flouri, Christina, Jackson, Laurence H., Wang, Wei, Blundell, Michael P., Liu, Shanrun, Eaton, Simon, Bakhamis, Nahla, Ramachandra, Durrgah Latchumi, Maghsoudlou, Panayiotis, Urbani, Luca, Waddington, Simon N., Eddaoudi, Ayad, Archer, Joy, Antoniou, Michael N., Stuckey, Daniel J., Schmidt, Manfred, Thrasher, Adrian J., Ryan, Thomas M., De Coppi, Paolo, David, Anna L.

Funder: UK Thalassaemia Society
In utero gene therapy (IUGT) to the fetal hematopoietic compartment could be used to treat congenital blood disorders such as β-thalassemia. A humanised mouse model of β-thalassemia was used, in which heterozygo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c68b179e5c406a7933f94d2cf23e94e

In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanised Mouse Model and Its Progress Can Be Monitored Using MRI Techniques.

Autor: Shangaris P; Institute for Women's Health, University College London, 86-96 Chenies Mews, London, WC1E 6HX, UK. p.shangaris@ucl.ac.uk.; UCL Institute of Child Health, UCL, London, United Kingdom. p.shangaris@ucl.ac.uk., Loukogeorgakis SP; UCL Institute of Child Health, UCL, London, United Kingdom., Subramaniam S; UCL Institute of Child Health, UCL, London, United Kingdom., Flouri C; Department of Medical and Molecular Genetics, KCL, London, United Kingdom., Jackson LH; Centre for Advanced Biomedical Imaging, UCL, London, United Kingdom., Wang W; Department of Translational Oncology, National Centre for Tumour Diseases, Heidelberg, Germany., Blundell MP; UCL Institute of Child Health, UCL, London, United Kingdom., Liu S; Biochemistry and Molecular Genetics, UAB, Birmingham, Alabama, United States., Eaton S; UCL Institute of Child Health, UCL, London, United Kingdom., Bakhamis N; Institute for Women's Health, University College London, 86-96 Chenies Mews, London, WC1E 6HX, UK., Ramachandra DL; UCL Institute of Child Health, UCL, London, United Kingdom., Maghsoudlou P; UCL Institute of Child Health, UCL, London, United Kingdom., Urbani L; UCL Institute of Child Health, UCL, London, United Kingdom., Waddington SN; Institute for Women's Health, University College London, 86-96 Chenies Mews, London, WC1E 6HX, UK.; Wits/SAMRC Antiviral Gene Therapy Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Eddaoudi A; UCL Institute of Child Health, UCL, London, United Kingdom., Archer J; Central Diagnostic Services, Queen's Vet School Hospital, University of Cambridge, Cambridge, United Kingdom., Antoniou MN; Department of Medical and Molecular Genetics, KCL, London, United Kingdom., Stuckey DJ; Centre for Advanced Biomedical Imaging, UCL, London, United Kingdom., Schmidt M; Department of Translational Oncology, National Centre for Tumour Diseases, Heidelberg, Germany., Thrasher AJ; UCL Institute of Child Health, UCL, London, United Kingdom., Ryan TM; Biochemistry and Molecular Genetics, UAB, Birmingham, Alabama, United States., De Coppi P; UCL Institute of Child Health, UCL, London, United Kingdom., David AL; Institute for Women's Health, University College London, 86-96 Chenies Mews, London, WC1E 6HX, UK.

Publikováno v: Scientific reports [Sci Rep] 2019 Aug 12; Vol. 9 (1), pp. 11592. Date of Electronic Publication: 2019 Aug 12.