Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rama Y, Chandrasekaran"'
Autor:
Rama Y. Chandrasekaran, Jiri Aubrecht, Frederick R. Nelson, Linda A. Chatman, Hans Rollema, Frank M. Nedza, John M. Marcek, Philip A. Iredale, Jennifer B. Munzner, Betty Pettersen, Raggon Jeffrey W, David M. Rubitski, Julie Cianfrogna, Larry C. James, Karen W. Cook, Michael J. Banker, Diane F. Wong, Anne W. Schmidt, Michael Homiski, Howard Harry R, Daniel J. Lettiere, Butler Todd W, Scot Richard Mente, Jody Freeman, Travis T. Wager, Douglas K. Spracklin
Publikováno v:
Journal of Medicinal Chemistry. 54:7602-7620
The discovery of two histamine H3 antagonist clinical candidates is disclosed. The pathway to identification of the two clinical candidates, 6 (PF-03654746) and 7 (PF-03654764) required five hypothesis driven design cycles. The key to success in iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c253ef2a0b55c8bf1f6522eccc0c6ed
https://doi.org/10.1021/jm200939b
https://doi.org/10.1021/jm200939b
Autor:
Travis T, Wager, Betty A, Pettersen, Anne W, Schmidt, Douglas K, Spracklin, Scot, Mente, Todd W, Butler, Harry, Howard, Daniel J, Lettiere, David M, Rubitski, Diane F, Wong, Frank M, Nedza, Frederick R, Nelson, Hans, Rollema, Jeffrey W, Raggon, Jiri, Aubrecht, Jody K, Freeman, John M, Marcek, Julie, Cianfrogna, Karen W, Cook, Larry C, James, Linda A, Chatman, Philip A, Iredale, Michael J, Banker, Michael L, Homiski, Jennifer B, Munzner, Rama Y, Chandrasekaran
Publikováno v:
Journal of medicinal chemistry. 54(21)
The discovery of two histamine H(3) antagonist clinical candidates is disclosed. The pathway to identification of the two clinical candidates, 6 (PF-03654746) and 7 (PF-03654764) required five hypothesis driven design cycles. The key to success in id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2437f9ba9156d813302f64ee16a8582b
https://pubmed.ncbi.nlm.nih.gov/21928839
https://pubmed.ncbi.nlm.nih.gov/21928839
Publikováno v:
ChemInform. 23
Chiral N1-protected vicinal diamines derived from amino acids were condensed with 2-amino-6-chloro-5-nitro-4(3H)-pyrimidinone, the nitro group reduced, and the amine deprotected. Oxidative cyclization of the resulting triaminopyrimidinone via quinoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2903d8e17c76627267d1c581eee1edb
https://doi.org/10.1002/chin.199252220
https://doi.org/10.1002/chin.199252220
Publikováno v:
The Journal of Organic Chemistry. 57:4470-4477
Chiral N1-protected vicinal diamines derived from amino acids were condensed with 2-amino-6-chloro-5-nitro-4(3H)-pyrimidinone, the nitro group reduced, and the amine deprotected. Oxidative cyclization of the resulting triaminopyrimidinone via quinoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d364b97407dace75c905c842266eda51
https://doi.org/10.1021/jo00042a030
https://doi.org/10.1021/jo00042a030
Autor:
Qing-Jun Meng, Michael Marconi, Andrew S. I. Loudon, Jeffrey F. Ohren, Michael H. Hastings, Travis T. Wager, Elizabeth S. Maywood, Matt Griffor, Michael Bass, Francis Rajamohan, David M. Rubitski, Butler Todd W, Angela C. Doran, Jessica Adams, Megan Serpa, Katherine Fisher, Yuhpyng Chen, Rama Y. Chandrasekaran, Michelle Claffey, Kevin M. Walton, Martin Sládek
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 330(2)
The circadian clock links our daily cycles of sleep and activity to the external environment. Deregulation of the clock is implicated in a number of human disorders, including depression, seasonal affective disorder, and metabolic disorders. Casein k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3a1e460a380959b997c3bfe852e82e
https://pubmed.ncbi.nlm.nih.gov/19458106
https://pubmed.ncbi.nlm.nih.gov/19458106