Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Rama S. Sodum"'
Autor:
Joel Reinhardt, Dhimant Desai, Emerich S. Fiala, Rama S. Sodum, Ock Soon Sohn, Chung Xiou Wang, Junji Tsurutani, Cesar Aliaga, Phillip A. Dennis, Eleanore Seibert, Karam El-Bayoumy
Publikováno v:
Carcinogenesis. 26:605-612
The development of effective chemopreventive agents against cigarette smoke-induced lung cancer could be greatly facilitated by the availability of suitable laboratory animal models. Here we report that male Hartley guinea pigs treated with cigarette
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f25f4f8b2efe9a1e33e2b0c6f3ed9d6
https://doi.org/10.1093/carcin/bgh341
https://doi.org/10.1093/carcin/bgh341
Autor:
Emerich S. Fiala, Rama S. Sodum
Publikováno v:
Chemical Research in Toxicology. 14:438-450
Peroxynitrite, the reaction product of nitric oxide and superoxide anion, and a powerful oxidant, was found to nitrate as well as oxidize adenine, guanine, and xanthine nucleosides. A highly sensitive reverse-phase HPLC method with a dual-mode electr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e04865b752e057dafb1c5790e63f2b0
https://doi.org/10.1021/tx000189s
https://doi.org/10.1021/tx000189s
Autor:
Emerich S. Fiala, Rama S. Sodum
Publikováno v:
Chemical Research in Toxicology. 10:1420-1426
Previously, the secondary nitroalkane 2-nitropropane, a strong hepatocarcinogen in rats, had been shown to induce the formation of 8-aminoguanine in both DNA and RNA of rat liver through a sulfotransferase-mediated pathway. This pathway was postulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884090ee2e9f041e1c2af69e60a307f9
https://doi.org/10.1021/tx970137b
https://doi.org/10.1021/tx970137b
Publikováno v:
Carcinogenesis. 18:1809-1815
We observed that pretreatment of male F344 rats with benzyl selenocyanate, a versatile organoselenium chemopreventive agent in several animal model systems, decreases the levels of DNA and RNA modifications produced in the liver by the hepatocarcinog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9703c6a44c0a371d4a8af80def1be7e1
https://doi.org/10.1093/carcin/18.9.1809
https://doi.org/10.1093/carcin/18.9.1809
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:469-472
The 6-alkenyluracil nucleosides ( 7a–e ) and bases ( 14a–i ) were synthesized and evaluated for their ability to inhibit the growth of mouse leukemia L1210 cells in vitro . While several of the free bases are cytotoxic, with IC 50 values in the 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68b74d569d0088007e2332dae087351f
https://doi.org/10.1016/0960-894x(94)80018-9
https://doi.org/10.1016/0960-894x(94)80018-9
Publikováno v:
ChemInform. 25
The 6-alkenyluracil nucleosides ( 7a–e ) and bases ( 14a–i ) were synthesized and evaluated for their ability to inhibit the growth of mouse leukemia L1210 cells in vitro . While several of the free bases are cytotoxic, with IC 50 values in the 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4f3d5e55c17e0fcefa35aabb461d4e
https://doi.org/10.1002/chin.199431271
https://doi.org/10.1002/chin.199431271
Publikováno v:
Analytical biochemistry. 280(2)
3-Nitrotyrosine, a product of tyrosine nitration, is useful as a marker for the generation of reactive nitrogen oxide species with short half-lives such as peroxynitrite. A reverse-phase high-pressure liquid chromatographic method using a dual-mode e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bab72f1f1b72a8af6255a5b126c3d89
https://pubmed.ncbi.nlm.nih.gov/10790311
https://pubmed.ncbi.nlm.nih.gov/10790311
Autor:
Emerich S. Fiala, Rama S. Sodum
Publikováno v:
Chemical research in toxicology. 11(12)
2-Nitropropane, an industrial chemical and a hepatocarcinogen in rats, induces aryl sulfotransferase-mediated liver DNA and RNA base modifications [Sodum, R. S., Sohn, O. S., Nie, G., and Fiala, E. S. (1994) Chem. Res. Toxicol. 7, 344-351]. Two of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e602514ca3a9ded09d45bc06ff408a5
https://pubmed.ncbi.nlm.nih.gov/9860487
https://pubmed.ncbi.nlm.nih.gov/9860487
Publikováno v:
Chemical research in toxicology. 7(3)
8-Aminoguanine had previously been identified as one of the nucleic acid base modifications produced in livers of rats by treatment with the hepatocarcinogen 2-nitropropane (2-NP), and a hypothetical mechanism of activation of 2-NP to hydroxylamine-O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e686b9f9d65a2ebee6a1055b0776d9
https://pubmed.ncbi.nlm.nih.gov/7521230
https://pubmed.ncbi.nlm.nih.gov/7521230
Publikováno v:
Cancer letters. 74(1-2)
2-Nitropropane (2-NP), a hepatocarcinogen in male Sprague-Dawley rats but not, under the same conditions, in male New Zealand White rabbits, induces characteristic base modifications in rat liver DNA and RNA including increases in 8-oxoguanine and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56107119acbc05c7a0de296a35a0d93
https://pubmed.ncbi.nlm.nih.gov/7506989
https://pubmed.ncbi.nlm.nih.gov/7506989