Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rama Rao Manam"'
Autor:
Venkat R. Macherla, Katherine A. McArthur, Barbara C. M. Potts, Rama Rao Manam, Michael Groll
Publikováno v:
Journal of Medicinal Chemistry. 52:5420-5428
Many marketed drugs contain fluorine, reflecting its ability to modulate a variety of biological responses. The unique 20S proteasome inhibition profile of fluorosalinosporamide compared to chlorinated anticancer agent salinosporamide A (NPI-0052) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4a9b704fd993b8cf996a1a138e9c31
https://doi.org/10.1021/jm900559x
https://doi.org/10.1021/jm900559x
Publikováno v:
Tetrahedron Letters. 48:2537-2540
Salinosporamide A (NPI-0052, 1), a highly potent 20S proteasome inhibitor, has been prepared from its ketone precursor (2) by asymmetric enzymatic reduction. The yields are quantitative with complete stereoselective conversion to the desired product,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e29ae186b3327d43d0753d18d60afa67
https://doi.org/10.1016/j.tetlet.2007.02.017
https://doi.org/10.1016/j.tetlet.2007.02.017
Autor:
Saskia T. C. Neuteboom, Scott S Mitchell, Barbara C. M. Potts, Jianlin Xu, Gordafaried Deyanat-Yazdi, Sy Teisan, Ta-Hsiang Chao, Katherine Anne Reed, Rama Rao Manam, Kin S. Lam
Publikováno v:
Journal of Natural Products. 70:269-276
Salinosporamide A (NPI-0052; 3), a highly potent inhibitor of the 20S proteasome, is currently in phase I clinical trials for the treatment of cancer. During the course of purifying multigram quantities of 3 from Salinispora tropica fermentation extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3effc54d9880cd0e7e895ffdb1e4c4
https://doi.org/10.1021/np0603471
https://doi.org/10.1021/np0603471
Autor:
Gordafaried Deyanat-Yazdi, Ta-Hsiang Chao, Paul R. Jensen, Bao Mai, Kin S. Lam, Barbara C. M. Potts, Michael A. Palladino, William Fenical, Saskia T. C. Neuteboom, Katherine Anne Reed, Benjamin Nicholson, Scott S Mitchell, Rama Rao Manam, Venkat R. Macherla
Publikováno v:
Journal of Medicinal Chemistry. 48:3684-3687
Salinosporamide A (1, NPI-0052) is a potent proteasome inhibitor in development for treating cancer. In this study, a series of analogues was assayed for cytotoxicity, proteasome inhibition, and inhibition of NF-kappaB activation. Marked reductions i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb6efcee18907297287cfa16b47c94b4
https://doi.org/10.1021/jm048995+
https://doi.org/10.1021/jm048995+
Autor:
Benjamin Nicholson, Barbara C. M. Potts, Rama Rao Manam, David White, Sy Teisan, D.A. Mosca, Kin S. Lam, Saskia T. C. Neuteboom, G. K. Lloyd, Jennifer Grodberg
Publikováno v:
Journal of Natural Products. 68:240-243
A strain of Streptomyces nodosus (NPS007994) isolated from a marine sediment collected in Scripps Canyon, La Jolla, California, was found to produce lajollamycin (1), a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic. The structure was esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0be9c5cd9713d34cb01e69ec0462a3
https://doi.org/10.1021/np049725x
https://doi.org/10.1021/np049725x
Autor:
Ta-Hsiang Chao, Bruno Hagenbuch, Saskia T. C. Neuteboom, Rama Rao Manam, Barbara C. M. Potts, Amanda Obaidat, G. Kenneth Lloyd, S. J. Enna, Jeffrey Weiss, Katherine A. McArthur, Brett Wahlgren, Michael A. Palladino, Venkat R. Macherla
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 337(2)
The present study was undertaken to compare the cellular transport characteristics of [(3)H]NPI-0052 (1R,4R,5S)-4-(2-chloroethyl)-1-((S)-((S)-cyclohex-2-enyl)(hydroxy)methyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione (marizomib; salinospora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dece95f1e2609f46b7c90f71b5745e96
https://pubmed.ncbi.nlm.nih.gov/21303921
https://pubmed.ncbi.nlm.nih.gov/21303921
Autor:
Saskia T. C. Neuteboom, Chris W Dring, Venkat R. Macherla, Barbara C. M. Potts, Kin S. Lam, Rama Rao Manam, Ginger Tsueng, Jeffrey Weiss
Publikováno v:
Journal of natural products. 72(2)
Large-scale fermentation of the marine actinomycete Salinispora tropica for production of salinosporamide A (NPI-0052; 1) clinical trials materials provided crude extracts containing minor secondary metabolites, including salinosporamide B (2) and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88399390986f5fdc878e6f5b997692be
https://pubmed.ncbi.nlm.nih.gov/19133779
https://pubmed.ncbi.nlm.nih.gov/19133779
Autor:
Saskia Theodora Cornelia Neuteboom, Katherine A McArthur, Vito J Palombella, Michael Groll, Ta-Hsiang Chao, G Kenneth Lloyd, Janid A. Ali, Barbara Christine Potts, Rama Rao Manam, Venkat R Macherla, Michael A Palladino, Jeffrey Weiss
Publikováno v:
Journal of medicinal chemistry. 51(21)
Salinosporamide A ( 1 (NPI-0052)) is a potent, monochlorinated 20S proteasome inhibitor in clinical trials for the treatment of cancer. To elucidate the role of the chlorine leaving group (LG), we synthesized analogues with a range of LG potentials a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e220dba139a3af7c9357d5c26cc96432
https://pubmed.ncbi.nlm.nih.gov/18939815
https://pubmed.ncbi.nlm.nih.gov/18939815
Autor:
Venkat R. Macherla, Rama Rao Manam, Barbara Christine Potts, Katherine A. McArthur, Taotao Ling
Publikováno v:
Organic letters. 9(12)
A novel enantioselective total synthesis of 20S proteasome inhibitor Salinosporamide A (NPI-0052; 1) is presented. Key features include intramolecular aldol cyclization of 6 to simultaneously generate the three chiral centers of advanced intermediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a133b5e6d0bbb19f7ee06d2d5f49a67
https://pubmed.ncbi.nlm.nih.gov/17497868
https://pubmed.ncbi.nlm.nih.gov/17497868
Autor:
D. John Faulkner, Daniel Schlawe, David W. Kim, Kyriacos C. Nicolaou, Deborah A. Longbottom, Dimitrios E. Lizos, Rita G. de Noronha, Rama Rao Manam
Publikováno v:
ChemInform. 37
The isolation from the marine sponge Leiosella cf. arenifibrosa and structural elucidation of halipeptin D (5), a relative of the previously isolated halipeptins A–C (1–3), is described along with the total synthesis of a number of oxazoline anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f5fc5a5e8aeb8ba871871e09cf3a742
https://doi.org/10.1002/chin.200615184
https://doi.org/10.1002/chin.200615184