Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rama Kannan"'
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65610 (2013)
Cataract is characterized by progressive protein aggregation and loss of vision. α-Crystallins are the major proteins in the lens responsible for maintaining transparency. They exist in the lens as highly polydisperse oligomers with variable numbers
Externí odkaz:
https://doaj.org/article/d2d668099d0140d8a7dae8283047cebd
Autor:
Stéphane Ribieras, Rama Kannan, Isabelle Stoll, Catherine Tomasetto, Marie-Christine Rio, Carine Bossenmeyer-Pourié, Lars Thim, Corinne Wendling
Publikováno v:
The Journal of Cell Biology
Trefoil factor (TFF)1 is synthesized and secreted by the normal stomach mucosa and by the gastrointestinal cells of injured tissues. The link between mouse TFF1 inactivation and the fully penetrant antropyloric tumor phenotype prompted the classifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e2e6f24dd378c07fc4c1a49cb5c434
https://doi.org/10.1083/jcb200108056
https://doi.org/10.1083/jcb200108056
Autor:
Vincent Dive, Athanasios Yiotakis, Anne-Laure Gall, Marie-Christine Rio, Dino Moras, Marc Ruff, Philippe Cuniasse, Paul Basset, Rama Kannan
Publikováno v:
Journal of Molecular Biology. 307:577-586
Stromelysin-3 (ST3) is a matrix metalloproteinase (MMP-11) whose proteolytic activity plays an important role in tumorigenicity enhancement. In breast cancer, ST3 is a bad prognosis marker: its expression is associated with a poor clinical outcome. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::197d1d6c441a507316213c1ccaf32ef5
https://doi.org/10.1006/jmbi.2001.4493
https://doi.org/10.1006/jmbi.2001.4493
Autor:
Anne Boulay, Rama Kannan, Béatrice Holtz, Artur Mucha, Philippe Cuniasse, Paul Basset, Fabrice Beau, Vincent Dive
Publikováno v:
Biochemistry. 38:12174-12179
The influence of Gln215 in stromelysin-3 (MMP-11), a residue located in the S1' subsite, was determined by producing three single mutants of this position. As compared to wild-type stromelysin-3, the kinetic parameters K(M) and k(cat) for the degrada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1ec93846680bedc0e26373577dfdd2
https://doi.org/10.1021/bi990876m
https://doi.org/10.1021/bi990876m
Autor:
Marie-Christine Rio, Philippe Cuniasse, Vera Knäuper, and Athanasios Yiotakis, Dimitris Georgiadis, Gillian Murphy, Paul Basset, Vincent Dive, ‡ Karine Lucet-Levannier, Artur Mucha, Fabrice Beau, Stamatia Vassiliou, Rama Kannan
Publikováno v:
Journal of Medicinal Chemistry. 42:2610-2620
Several phosphinic pseudo-tripeptides of general formula R-XaaPsi(PO(2)-CH(2))Xaa'-Yaa'-NH(2) were synthesized and evaluated for their in vitro activities to inhibit stromelysin-3, gelatinases A and B, membrane type-1 matrix metalloproteinase, collag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3708db4988a191221a9dc265cff0e397
https://doi.org/10.1021/jm9900164
https://doi.org/10.1021/jm9900164
Autor:
Vincent Dive, John G. Kochins, Agnès Noël, Rama Kannan, Susan P. Manly, Paul Basset, Mostafa El Fahime, Marc Ruff, Marie-Christine Rio, Jean-Michel Foidart, Isabelle Stoll
Publikováno v:
Protein Expression and Purification. 16:76-83
The matrix metalloproteinase (MMP) stromelysin-3 (ST3) has been shown to be involved in malignant tumor progression and therefore represents an attractive therapeutical target. In order to screen for ST3 synthetic inhibitors, we have produced and pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e7b423b380be20a19ce211346cd6f8
https://doi.org/10.1006/prep.1999.1068
https://doi.org/10.1006/prep.1999.1068
Autor:
Vincent Dive, Rama Kannan, Athanasios Yiotakis, Artur Mucha, Philippe Cuniasse, Paul Basset, Fabrice Beau
Publikováno v:
Journal of Biological Chemistry. 273:2763-2768
The influence of the substrate P1′ position on the specificity of two zinc matrix metalloproteases, membrane type-1 matrix metalloprotease (MT1-MMP) and stromelysin-3 (ST3), was evaluated by synthesizing a series of fluorogenic substrates of genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1f9659e50a87801262209f94103910
https://doi.org/10.1074/jbc.273.5.2763
https://doi.org/10.1074/jbc.273.5.2763
Autor:
Andrea B. Kohn, Anahit V. Azaryan, Kurt W. Miller, Vivian Hook, Kim Moran, Martin R. Schiller, Mark O. Lively, Rama Kannan
Publikováno v:
Protein Expression and Purification. 10:80-88
Prohormone substrates are required for investigation of the proteolytic processing of prohormones and proproteins into active peptide hormones and neurotransmitters. However, the lack of prohormone proteins has been a limiting factor in elucidating p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f27cc76db1f8d880f9981c995f0d2e4
https://doi.org/10.1006/prep.1996.0715
https://doi.org/10.1006/prep.1996.0715
Autor:
Marie-Christine Rio, Akiko Okada, Paul Basset, Marie-Pierre Chenard, Patrick Anglard, Isabelle Stoll, Rama Kannan, Jean-Pierre Bellocq
Publikováno v:
Matrix Biology. 15:535-541
The matrix metalloproteinases (MMPs) are extracellular zinc-enzymes implicated in a number of physiological and pathological tissue remodeling processes, including cancer progression. For a long time they have been thought to be produced by malignant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696fc784ce103be6208f6686ed85ae3f
https://doi.org/10.1016/s0945-053x(97)90028-7
https://doi.org/10.1016/s0945-053x(97)90028-7