Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Rama, Natarajan"'
Autor:
Kiran Sriram, Zhijie Qi, Dongqiang Yuan, Naseeb Kaur Malhi, Xuejing Liu, Riccardo Calandrelli, Yingjun Luo, Alonso Tapia, Shengyan Jin, Ji Shi, Martha Salas, Runrui Dang, Brian Armstrong, Saul J Priceman, Ping H Wang, Jiayu Liao, Rama Natarajan, Sheng Zhong, Zhen Bouman Chen
Publikováno v:
eLife, Vol 13 (2024)
Chromatin-associated RNAs (caRNAs) form a relatively poorly recognized layer of the epigenome. The caRNAs reported to date are transcribed from the nuclear genome. Here, leveraging a recently developed assay for detection of caRNAs and their genomic
Externí odkaz:
https://doaj.org/article/323739c0fbfa47fda16f95c298657bec
Autor:
Maryam Abdollahi, Mitsuo Kato, Linda Lanting, Ragadeepthi Tunduguru, Mei Wang, Yangmeng Wang, Patrick T. Fueger, Qiong Wang, Wendong Huang, Rama Natarajan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 115-130 (2022)
We investigated the role of microRNA (miR-379) in the pathogenesis of obesity, adipose tissue dysfunction, and insulin resistance (IR). We used miR-379 knockout (miR-379KO) mice to test whether loss of miR-379 affects high-fat diet (HFD)-induced obes
Externí odkaz:
https://doaj.org/article/98845e06c3e44f98a248b2f2ced158b5
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
With advancements in cancer treatment and supportive care, there is a growing population of childhood cancer survivors who experience a substantial burden of comorbidities related to having received cancer treatment at a young age. Despite an overall
Externí odkaz:
https://doaj.org/article/b6454a18e6d84b019e8073bdf2193ce6
Autor:
Mitsuo Kato, Zhuo Chen, Sadhan Das, Xiwei Wu, Jinhui Wang, Arthur Li, Wei Chen, Walter Tsark, Ragadeepthi Tunduguru, Linda Lanting, Mei Wang, Roger Moore, Markus Kalkum, Maryam Abdollahi, Rama Natarajan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Background: MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play key roles in diabetic kidney disease (DKD). The miR-379 megacluster of miRNAs and its host transcript lnc-megacluster (lncMGC) are regulated by transforming growth factor-β (TGF-
Externí odkaz:
https://doaj.org/article/44374e3670e84c119d07b8ac603d7f01
Autor:
Eryun Zhang, Lihua Jin, Yangmeng Wang, Jui Tu, Ruirong Zheng, Lili Ding, Zhipeng Fang, Mingjie Fan, Ismail Al-Abdullah, Rama Natarajan, Ke Ma, Zhengtao Wang, Arthur D. Riggs, Sarah C. Shuck, Li Yang, Wendong Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Mammalian 5′-AMP-activated protein kinase (AMPK) is a nutrient sensor and a therapeutic target for Type 2 Diabetes. Here the authors report that intestinal AMPK modulates brown adipose tissue thermogenesis through anti-microbial peptide controlled
Externí odkaz:
https://doaj.org/article/485d44f0baf04706b6b2590153a90ce8
Autor:
Xiaofang Tang, Yingjun Luo, Dongqiang Yuan, Riccardo Calandrelli, Naseeb Kaur Malhi, Kiran Sriram, Yifei Miao, Chih-Hong Lou, Walter Tsark, Alonso Tapia, Aleysha T. Chen, Guangyu Zhang, Daniel Roeth, Markus Kalkum, Zhao V. Wang, Shu Chien, Rama Natarajan, John P. Cooke, Sheng Zhong, Zhen Bouman Chen
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Impaired angiogenesis in diabetes is a key process contributing to ischemic diseases such as peripheral arterial disease. Epigenetic mechanisms, including those mediated by long noncoding RNAs (lncRNAs), are crucial links connecting diabetes and the
Externí odkaz:
https://doaj.org/article/17124107ddb64a87bca90326d3684d5f
Autor:
Zhen B. Chen, Xiaofang Tang, Kiran Sriram, Yingjun Luo, Dongqiang Yuan, Naseeb Kaur Malhi, Xuejing Liu, Rama Natarajan
Publikováno v:
JVS - Vascular Science, Vol 4, Iss , Pp 100167- (2023)
Externí odkaz:
https://doaj.org/article/e92b2d72563743cc83fc12ef4a066d86
Autor:
Xiaofang Tang, Chih-Hung Lai, Naseeb K. Malhi, Rahuljeet Chadha, Yingjun Luo, Xuejing Liu, Dongqiang Yuan, Alonso Tapia, Maryam Abdollahi, Guangyu Zhang, Riccardo Calandrelli, Yan-Ting Shiu, Zhao V. Wang, June-Wha Rhee, Sheng Zhong, Rama Natarajan, Zhen Bouman Chen
Publikováno v:
Non-Coding RNA, Vol 9, Iss 3, p 31 (2023)
(1) Background: Hypertension is a complex, multifactorial disease that is caused by genetic and environmental factors. Apart from genetic predisposition, the mechanisms involved in this disease have yet to be fully understood. We previously reported
Externí odkaz:
https://doaj.org/article/7f407682b33a4841a582e688cccf0fb7
Autor:
Mitsuo Kato, Maryam Abdollahi, Ragadeepthi Tunduguru, Walter Tsark, Zhuo Chen, Xiwei Wu, Jinhui Wang, Zhen Bouman Chen, Feng-Mao Lin, Linda Lanting, Mei Wang, Janice Huss, Patrick T Fueger, David Chan, Rama Natarajan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Kato, Abdollahi et al. identify a redox protein thioredoxin and mitochondrial fission-1 (FIS1) protein as miR-379 targets in mouse kidney. They find that miR-379 knockout mice are protected from diabetic kidney disease by enhancing mitophagy via FIS1
Externí odkaz:
https://doaj.org/article/18cedf624dff4f77b17af0446ccad171
Autor:
Kiran Sriram, Yingjun Luo, Dongqiang Yuan, Naseeb Kaur Malhi, Alonso Tapia, Vishnu Amaram Samara, Rama Natarajan, Zhen Bouman Chen
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Vascular endothelial cells (ECs) play a pivotal role in whole body homeostasis. Recent advances have revealed enhancer-associated long non-coding RNAs (lncRNAs) as essential regulators in EC function. We investigated LINC00607, a super enhancer-deriv
Externí odkaz:
https://doaj.org/article/ee01e576e0bc45e58b33cf98cf404cb5