Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ram Thaimattam"'
Publikováno v:
CrystEngComm. 20:3490-3504
Cocrystallization of two multifunctional structural isomers viz. orotic and isoorotic acids was explored with a series of amine and pyridine-based coformers. The system has been chosen in such a way so that robustness of the acid⋯pyridine synthon w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63d19563906b85fa84602e7175c08ed2
https://doi.org/10.1039/c8ce00486b
https://doi.org/10.1039/c8ce00486b
Publikováno v:
CrystEngComm. 19:2914-2924
Our attempts to cocrystallize three sulfa drugs (SDs), viz., sulfamerazine (smr), sulfamethazine (smz) and sulfamethoxazole (smx) with four coformers, viz., niflumic acid and flufenamic acid, 4-aminopyridine and piperazine led to eight new solids. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0588512199fdcef71add669fb96b38e7
https://doi.org/10.1039/c7ce00217c
https://doi.org/10.1039/c7ce00217c
Publikováno v:
Crystal Growth & Design. 13:360-366
Crystallization of p-aminosalicylic acid, an anti-tuberculosis drug, in the presence of pyridine derivatives as coformers led to formation of nine multicomponent solids that include salts, a salt co-crystal hydrate, co-crystals, and co-crystal polymo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d09b5918286d683be2486d64189a71
https://doi.org/10.1021/cg3015332
https://doi.org/10.1021/cg3015332
Autor:
Gautam R. Desiraju, Srinivasulu Aitipamula, Miranda L. Cheney, Changquan Calvin Sun, Preetam P. Ghogale, Soumyajit Ghosh, T. Rajamannar, David R. Weyna, Venu R. Vangala, Rahul Banerjee, Gargi Mukherjee, Palash Sanphui, T. N. Guru Row, Arvind K. Bansal, Ram Thaimattam, Robin D. Rogers, Arunachalam Ramanan, Jennifer A. Swift, Piotr H. Karpinski, Kumar Biradha, Naír Rodríguez-Hornedo, Amol G. Dikundwar, C. Malla Reddy, Allan S. Myerson, Angshuman Roy Choudhury, Ning Shan, Brian Moulton, Rajesh Kumar Thaper, Sajesh P. Thomas, Naga Kiran Duggirala, Srinu Tothadi, Ritesh Dubey, Ram K. R. Jetti, Pramod Kumar Goswami, Narayan Variankaval, Ganesh Shete, Dinesh Kumar, Michael J. Zaworotko, Tejender S. Thakur, Arijit Mukherjee, Peddy Vishweshwar, Poonam Kaushik, N. Rajesh Goud, Vibha Puri, Vineet Kumar, Amit Singh
Publikováno v:
Crystal Growth & Design. 12:2147-2152
The December 2011 release of a draft United States Food and Drug Administration (FDA) guidance concerning regulatory classification of pharmaceutical cocrystals of active pharmaceutical ingredients (APIs) addressed two matters of topical interest to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aeaa3133d01c2ebe86ef0e8ec318d5c
https://doi.org/10.1021/cg3002948
https://doi.org/10.1021/cg3002948
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 73:C424-C424
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54e5add2967d85781d8ee1dfed5c03e0
https://doi.org/10.1107/s2053273317091495
https://doi.org/10.1107/s2053273317091495
Publikováno v:
Acta Crystallographica Section B Structural Science. 64:483-490
The co-crystal structure of N-methylpiperidine betaine with N-methylpiperidine betaine hexafluorosilicate represents an unusual case of a salt co-crystal with a high Z′ value (3), unexpected conformational variability, and with nearly 50% of its co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6693ad70e4bc77c337028a995d28491
https://doi.org/10.1107/s0108768108011476
https://doi.org/10.1107/s0108768108011476
Publikováno v:
Current Pharmaceutical Design. 13:2751-2765
Protein kinases are involved in many diseases like cancer, inflammation, cardiovascular disease, and diabetes. They have become attractive target classes for drug development, making kinase inhibitors as important class of therapeutics. The success o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c6394c83967fa254713821dfd6d5aa
https://doi.org/10.2174/138161207781757042
https://doi.org/10.2174/138161207781757042
Publikováno v:
Journal of Molecular Structure. 828:19-24
A 1:1 complex between 4-( N -methylpiperidinium)-butyrate inner salt (betaine) and hydrobromide, MPBUH·Br, has been characterized by single crystal X-ray analysis. The crystals are monoclinic, space group P2 1 /c, with a = 8.284(1), b = 10.369(1), c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e644c8311ddb4a8db36932d6099367f9
https://doi.org/10.1016/j.molstruc.2006.05.035
https://doi.org/10.1016/j.molstruc.2006.05.035
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:4704-4712
Three-dimensional quantitative structure–activity relationship (3D-QSAR) analyses were carried out on quinazoline, quinoline, and cyanoquinoline derivatives inhibiting c-Src kinase. Comparative molecular field analysis (CoMFA) and comparative molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cad979a24bc885396798a019df9625
https://doi.org/10.1016/j.bmc.2005.04.065
https://doi.org/10.1016/j.bmc.2005.04.065
Autor:
Ram Thaimattam, Mariusz Jaskolski
Publikováno v:
Journal of Alloys and Compounds. 362:12-20
The paper discusses the high resolution and quality aspects of synchrotron radiation protein crystallography using examples from our own laboratory. The examples include two inhibitors of trypsin, one (CMTI) derived from plants, and one (BPTI) of mam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f68c53807b2f58c13e8fa796e6c23af
https://doi.org/10.1016/s0925-8388(03)00556-5
https://doi.org/10.1016/s0925-8388(03)00556-5