Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ram Sudheer Adluri"'
Autor:
Ram Sudheer Adluri, Mahesh Thirunavukkarasu, Lijun Zhan, Nageswara Rao Dunna, Yuzo Akita, Vaithinathan Selvaraju, Hajime Otani, Juan A Sanchez, Ye-Shih Ho, Nilanjana Maulik
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34790 (2012)
Oxidative stress plays a critical role in the pathophysiology of cardiac failure, including the modulation of neovascularization following myocardial infarction (MI). Redox molecules thioredoxin (Trx) and glutaredoxin (Grx) superfamilies actively mai
Externí odkaz:
https://doaj.org/article/a57dce194154469dbe00298c8d5ddedf
Autor:
Juan A. Sanchez, Gautam Maulik, Babatunde Oriowo, Guo-Hua Fong, Nageswara Rao Dunna, Ram Sudheer Adluri, Kotaro Takeda, Mahesh Thirunavukkarasu, Hajime Otani, Nilanjana Maulik, Lijun Zhan
Publikováno v:
Antioxidants & Redox Signaling. 15:1789-1797
Hypoxia-inducible transcription factor (HIF)-prolyl hydroxylases domain (PHD-1–3) are oxygen sensors that regulate the stability of the HIFs in an oxygen-dependent manner. Suppression of PHD enzymes leads to stabilization of HIFs and offers a poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80c5c4410809d970ca5ddea717d58fa
https://doi.org/10.1089/ars.2010.3769
https://doi.org/10.1089/ars.2010.3769
Autor:
Mahesh Thirunavukkarasu, Gautam Maulik, Katja Svennevig, Lijun Zhan, Nilanjana Maulik, Manashi Bagchi, Ram Sudheer Adluri
Publikováno v:
Cell Biochemistry and Biophysics. 67:281-286
Circumstantial evidence frequently implicates oxygen-derived free radicals and oxidative stress as mediators of myocardial ischemia/reperfusion (I/R) injury. Therefore, external supplementation of natural antioxidants plays a main role as cardioprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e1440d2a3678783a33a2a8dabe0672
https://doi.org/10.1007/s12013-011-9300-7
https://doi.org/10.1007/s12013-011-9300-7
Autor:
Mahesh Thirunavukkarasu, Nilanjana Maulik, Ye-Shih Ho, Lijun Zhan, Yuzo Akita, Gautam Maulik, Ram Sudheer Adluri, Samson Mathews Samuel, Hajime Otani
Publikováno v:
Journal of Molecular and Cellular Cardiology. 50:239-247
Oxidative stress plays a crucial role in disruption of neovascularization by alterations in thioredoxin 1 (Trx1) expression and its interaction with other proteins after myocardial infarction (MI). We previously showed that Trx1 has angiogenic proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251d5a20ac625fc0520cb0ae35b80975
https://doi.org/10.1016/j.yjmcc.2010.11.002
https://doi.org/10.1016/j.yjmcc.2010.11.002
Autor:
Padmanabhan Menon Venugopal, Vishwanathan Periyaswamy, Devipriya Nagarajan, Ram Sudheer Adluri
Publikováno v:
Fundamental & Clinical Pharmacology. 22:557-567
In the present study, ferulic acid (FA), a naturally occurring nutritional compound, was investigated for its protective effect against nicotine-induced toxicity in a dose dependent manner. The toxicity was induced by subcutaneous injection of nicoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735230fffe7763f1f1fef844e30b5ca5
https://doi.org/10.1111/j.1472-8206.2008.00622.x
https://doi.org/10.1111/j.1472-8206.2008.00622.x
Autor:
Juan A. Sanchez, Narasimham L. Parinandi, Ram Sudheer Adluri, Joshua W. Goldman, Naveed Hussain, Vaithinathan Selvaraju, Nilanjana Maulik
Publikováno v:
Antioxidantsredox signaling. 20(16)
Significance: In this review, we have discussed the efficacy and effect of small molecules that act as prolyl hydroxylase domain inhibitors (PHDIs). The use of these compounds causes upregulation of the pro-angiogenic factors and hypoxia inducible fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a573341b947bd3efae7ceff375d45446
https://pubmed.ncbi.nlm.nih.gov/23992027
https://pubmed.ncbi.nlm.nih.gov/23992027
Autor:
Lijun Zhan, Mahesh Thirunavukkarasu, Vaithinathan Selvaraju, Juan A. Sanchez, Guo-Hua Fong, Babatunde Oriowo, Kotaro Takeda, Nilanjana Maulik, Ram Sudheer Adluri
Publikováno v:
Current pharmaceutical design. 20(9)
The key oxygen sensing molecules, Prolyl-hydroxylase domain 1-3 enzymes (PHD1-3), regulate hypoxia-inducible factor (HIF) under hypoxia. In the settings of cardiomyopathy and ischemia-reperfusion injury, PHD3 expression is elevated, resulting in decr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fcf6066c1b32da6c5cf5c72c4f54fcf
https://pubmed.ncbi.nlm.nih.gov/23978105
https://pubmed.ncbi.nlm.nih.gov/23978105
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 24
BACKGROUND The present study aimed to evaluate the antihyperlipidemic effect of ferulic acid (FA) on carbon tetrachloride (CCl4)-treated rats. METHODS Female albino rats of the Wistar strain were used in the present study. The rats were divided into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2e71eb5a97245c88b1de4b66cd821b
https://doi.org/10.1515/jbcpp-2012-0053
https://doi.org/10.1515/jbcpp-2012-0053
Autor:
Bethi Sridhar Reddy, Jang B. Gupta, Jeyaraj Duraiswamy Athisayamani, Ram Sudheer Adluri, Joshi Hemant, Sayan Mitra, Arnab Roy Chowdhury, Srinivas Maddi, Vijaya G. Tirunagaru
Publikováno v:
Cancer Research. 76:373-373
PTEN somatic mutations occur in a large percentage of human cancers, from breast to prostate. Deletions of PTEN e.g. in prostate cancers are associated with tumor aggression and poor outcome, and up to 70 percent of prostate cancer patients have lost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d64c5b3e543bfa9dc3709967b8c9c6c
https://doi.org/10.1158/1538-7445.am2016-373
https://doi.org/10.1158/1538-7445.am2016-373
Autor:
Ram Sudheer Adluri, Jang B. Gupta, Joshi Hemant, Vijaya G. Tirunagaru, Kumaragurubaran Nagaswamy, Srinivas Maddi, Sayan Mitra
Publikováno v:
Cancer Research. 76:2643-2643
Kinase gene fusions have been implicated as oncogenic drivers promoting cell survival and proliferation. TrkA gene fusions have been reported in a number of cancer types including lung, colorectal, papillary thyroid, sarcoma, cholangiocarcinoma and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1819411cc09e7bbcfc4f5020c7a5ad34
https://doi.org/10.1158/1538-7445.am2016-2643
https://doi.org/10.1158/1538-7445.am2016-2643