Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ram Shankar Mani"'
Autor:
Arul M. Chinnaiyan, Sooryanarayana Varambally, Scott A. Tomlins, Robert J. Lonigro, Xuhong Cao, Aparna Ghosh, Lei Wang, J. Chad Brenner, Qi Cao, Matthew K. Iyer, Ram-Shankar Mani
Supplemental Materials and Methods from TMPRSS2–ERG-Mediated Feed-Forward Regulation of Wild-Type ERG in Human Prostate Cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2fa557f4d736ebfe18fa1e7a868408
https://doi.org/10.1158/0008-5472.22388219.v1
https://doi.org/10.1158/0008-5472.22388219.v1
Autor:
Michèle Orain, Lawrence E. Heisler, Alexander Gusev, Cindy Q. Yao, Matthew L. Freedman, Takafumi N. Yamaguchi, Ada Wong, Kathleen E. Houlahan, Vincent Huang, Ram Shankar Mani, Paul C. Boutros, Melvin L.K. Chua, Connor Bell, Thomas Kislinger, John Douglas Mcpherson, Lee Timms, Susmita G. Ramanand, Housheng Hansen He, Jiapei Yuan, Alain Bergeron, Hélène Hovington, Julie Livingstone, Mathieu Lupien, Shadrielle Melijah G. Espiritu, Yves Fradet, Mark Pomerantz, Edward P. O’Connor, Valérie Picard, Anamay Shetty, Alex Murison, Bogdan Pasaniuc, Bernard Têtu, Theodorus van der Kwast, Louis Lacombe, Yu Jia Shiah, Michelle Sam, Jeremy Johns, Alexandre Rouette, Michael Fraser, Ankit Sinha, Adrien Foucal, Robert G. Bristow, Musaddeque Ahmed
Publikováno v:
Nature Medicine. 25:1615-1626
Oncogenesis is driven by germline, environmental and stochastic factors. It is unknown how these interact to produce the molecular phenotypes of tumors. We therefore quantified the influence of germline polymorphisms on the somatic epigenome of 589 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c67083979c487da7774a4986c249f84b
https://doi.org/10.1038/s41591-019-0579-z
https://doi.org/10.1038/s41591-019-0579-z
Autor:
Chao Xing, Xiaowei Zhan, Ganesh V. Raj, Yunpeng Gao, Kathleen E. Houlahan, Suzanne Carreira, Jiapei Yuan, Johann S. de Bono, Kelly Daescu, Adam Sharp, Paul C. Boutros, Mohammed Kanchwala, Michael Q. Zhang, Adam Aslam, Susmita G. Ramanand, Wei Yuan, Guem Hee Baek, Alec Paschalis, Yong Chen, Nida Safdar, Ram Shankar Mani, Maryou B K Lambros
Publikováno v:
Journal of Clinical Investigation.
Transcriptional dysregulation is a hallmark of prostate cancer (PCa). We mapped the RNA polymerase II-associated (RNA Pol II-associated) chromatin interactions in normal prostate cells and PCa cells. We discovered thousands of enhancer-promoter, enha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea2d92d688ec48ea35d934222bc6fb81
https://doi.org/10.1172/jci134260
https://doi.org/10.1172/jci134260
Autor:
Johann S. de Bono, Ram Shankar Mani, Christina Guo, Jesús Gil, Angelo M. De Marzo, Charles G. Drake, Bora Gurel, Karen S. Sfanos, Andrea Alimonti
Publikováno v:
Nature Reviews Cancer
Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an altered microbiome being causally implicated. Intra-prostatic inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4629800eb3acac94d96f32f1156c9f39
http://hdl.handle.net/11577/3353017
http://hdl.handle.net/11577/3353017
Autor:
Bipasha Mukherjee, Yi Yin, Xiangyi Li, David Dolling, Ram Shankar Mani, Semini Sumanasuriya, Ganesh V. Raj, Yunpeng Gao, Mohammed Kanchwala, Adam Sharp, Guem Hee Baek, Wendy S. Halsey, Mateus Crespo, Sandeep Burma, Daniel Nava Rodrigues, Wei Yuan, Susmita G. Ramanand, Jon Welti, Adam Aslam, Rui Li, Ines Figueiredo, Cheng Ming Chiang, Ashley M. Hughes, Chao Xing, Johann S. de Bono
Publikováno v:
Cell Reports, Vol 22, Iss 3, Pp 796-808 (2018)
Cell reports
Cell reports
Summary BRD4 belongs to the bromodomain and extraterminal (BET) family of chromatin reader proteins that bind acetylated histones and regulate gene expression. Pharmacological inhibition of BRD4 by BET inhibitors (BETi) has indicated antitumor activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b38c89c4bcf3e0b839e77c3b892700
http://www.sciencedirect.com/science/article/pii/S2211124717319150
http://www.sciencedirect.com/science/article/pii/S2211124717319150
Autor:
Alisa E. Koch, Bradley J. Rabquer, Brendan A. Veeneman, Sameek Roychowdhury, Ram Shankar Mani, Saravana M. Dhanasekaran, Maxwell Tran, Xiangyi Li, Shanker Kalyana-Sundaram, Nallasivam Palanisamy, Hesham A. Sadek, Mohammad A. Amin, Lei Wang, Wataru Kimura, Arul M. Chinnaiyan, Adam Aslam, Susmita G. Ramanand, Payal Kapur, Xuhong Cao, Aparna Ghosh
Publikováno v:
Cell Reports. 17:2620-2631
Approximately 50% of prostate cancers are associated with gene fusions of the androgen-regulated gene TMPRSS2 to the oncogenic erythroblast transformation-specific (ETS) transcription factor ERG. The three-dimensional proximity of TMPRSS2 and ERG gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2e1b65f7ee413622fe1bff1d11f45b
https://doi.org/10.1016/j.celrep.2016.11.019
https://doi.org/10.1016/j.celrep.2016.11.019
Autor:
Ajith Tharakan, Ram Shankar Mani, Arunima Chatterjee, Anuranjan Anand, Dennis F. Xavier, Ravi Hiremagalore, Nishtha Pandey, B. Rajashekhar
Publikováno v:
Annals of Human Genetics. 80:11-19
Mutations in the gap-junction gene Cx30 (Connexin30, GJB6) are a known cause of hearing loss. Here, we report our findings on a large multigeneration family in which severe to profound sensorineural hearing impairment is associated with a variety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::129daa39cbce5c9a0e91808d50827efa
https://doi.org/10.1111/ahg.12141
https://doi.org/10.1111/ahg.12141
Autor:
Elizabeth A. Van Tubergen, Tarek Metwally, Arul M. Chinnaiyan, Christina Springstead Scanlon, Ram Shankar Mani, Mukesh K. Nyati, Nallasivam Palanisamy, Ronald C. Inglehart, Rogerio M. Castilho, Anastasia K. Yocum, Nickole Russo, Emily Bellile, Sooryanarayana Varambally, Rajat Banerjee, Nisha J. D'Silva, Min Liu, Venkatesha Basrur
Publikováno v:
Nature Communications. 7
Nature Communications 5 Article number: 452710.1038/ncomms5527 (2014); Published July312014; Updated February242016 In Fig. 4e,f of this Article, the plotted tumour volumes are incorrect due to an error in the formula used to convert length and width
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::372f2ddc95952d104a98097be7dd7de7
https://doi.org/10.1038/ncomms10726
https://doi.org/10.1038/ncomms10726
Autor:
Arie P. Otte, Rohit Mehra, Radhika Menawat, Daniel F. Camacho, Robert J. Lonigro, Irfan A. Asangani, Arul M. Chinnaiyan, Xiaojun Jing, Taibriana Schumann, Mark A. Rubin, Qi Cao, Kenneth J. Pienta, Mukesh K. Nyati, Javed Siddiqui, Sooryanarayana Varambally, Scott A. Tomlins, Ram Shankar Mani, Balabhadrapatruni V. S. K. Chakravarthi, Saravana M. Dhanasekaran, Bushra Ateeq, Lakshmi P. Kunju, Rui Wang, Nallasivam Palanisamy, Natalie McGregor, Heng Zheng
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 10, Pp 905-914 (2012)
Transcriptional repressors and corepressors play a critical role in cellular homeostasis and are frequently altered in cancer. C-terminal binding protein 1 (CtBP1), a transcriptional corepressor that regulates the expression of tumor suppressors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3827deccbc5ef6a7533e59b2b9ecc9
http://www.sciencedirect.com/science/article/pii/S1476558612800224
http://www.sciencedirect.com/science/article/pii/S1476558612800224
Autor:
Shin Mineishi, Koji Kato, Jina Wang, Arul M. Chinnaiyan, Kazuhiro Mochizuki, Yi Zhang, Ram Shankar Mani, Fang Xie, Victor E. Marquez, Shan He, Yongnian Liu, Evelyn Nieves, Sooryanarayana Varambally, Rork Kuick
Publikováno v:
Blood. 119:1274-1282
Abstract 820 Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment option for patients with hematological malignancies. However, its success is limited by life-threatening graft-versus-host disease (GVHD).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4a0e95816939c81f67655f98c8b302
https://doi.org/10.1182/blood-2011-06-364422
https://doi.org/10.1182/blood-2011-06-364422