Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ram P. Chakrabarty"'
Autor:
Nathan Meade, Helen K. Toreev, Ram P. Chakrabarty, Charles R. Hesser, Chorong Park, Navdeep S. Chandel, Derek Walsh
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Poxviruses are unusual DNA viruses that replicate in the cytoplasm. To do so, they encode approximately 100 immunomodulatory proteins that counteract cytosolic nucleic acid sensors such as cGAMP synthase (cGAS) along with several other antiv
Externí odkaz:
https://doaj.org/article/10cdeac366b04e5c96ee9f6eb5cecfe9
Autor:
Gregory S. McElroy, Ram P. Chakrabarty, Karis B. D’Alessandro, Karthik Vasan, Jerica Tan, Joshua S. Stoolman, Samuel E. Weinberg, Elizabeth M. Steinert, Paul A. Reyfman, Benjamin D. Singer, Warren C. Ladiges, Lin Gao, José Lopéz-Barneo, G. R. Scott Budinger, Navdeep S. Chandel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Aging in mammals leads to reduction in genes encoding the 45-subunit mitochondrial electron transport chain complex I. It has been hypothesized that normal aging and age-related diseases such as Parkinson’s disease are in part due to modes
Externí odkaz:
https://doaj.org/article/60fed24d6ad7416e898540e89de1e6c5
Autor:
Sean-Patrick Riechers, Jelena Mojsilovic-Petrovic, Tayler B. Belton, Ram P. Chakrabarty, Mehraveh Garjani, Valentina Medvedeva, Casey Dalton, Yvette C. Wong, Navdeep S. Chandel, Gerald Dienel, Robert G. Kalb
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101468- (2022)
Abstract Objectives: Normal cellular function requires a rate of ATP production sufficient to meet demand. In most neurodegenerative diseases (including Amyotrophic Lateral Sclerosis [ALS]), mitochondrial dysfunction is postulated raising the possibi
Externí odkaz:
https://doaj.org/article/793ced6e34284310b19b681f8b0d3fce
Autor:
Gregory S. McElroy, Ram P. Chakrabarty, Karis B. D’Alessandro, Yuan-Shih Hu, Karthik Vasan, Jerica Tan, Joshua S. Stoolman, Samuel E. Weinberg, Elizabeth M. Steinert, Paul A. Reyfman, Benjamin D. Singer, Warren C. Ladiges, Lin Gao, José Lopéz‑Barneo, Karen Ridge, G. R. Scott Budinger, Navdeep S. Chandel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/bf88894a9fed4d829ae4270cde645adf
Autor:
Christopher J. Yuskaitis, Jinita B. Modasia, Sandra Schrötter, Leigh-Ana Rossitto, Karenna J. Groff, Christopher Morici, Divakar S. Mithal, Ram P. Chakrabarty, Navdeep S. Chandel, Brendan D. Manning, Mustafa Sahin
Publikováno v:
Cell reports. 40(9)
Caloric restriction and acute fasting are known to reduce seizures but through unclear mechanisms. mTOR signaling has been suggested as a potential mechanism for seizure protection from fasting. We demonstrate that brain mTORC1 signaling is reduced a
Autor:
Lucy Granat, Debbra Y. Knorr, Daniel C. Ranson, Ram Prosad Chakrabarty, Navdeep S. Chandel, Joseph M. Bateman
Publikováno v:
Biology Open, Vol 13, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/46633e0f244a488ab57f783dc16bd03c
Autor:
Lucy Granat, Debbra Y Knorr, Daniel C Ranson, Emma L Hamer, Ram Prosad Chakrabarty, Francesca Mattedi, Laura Fort-Aznar, Frank Hirth, Sean T Sweeney, Alessio Vagnoni, Navdeep S Chandel, Joseph M Bateman
Publikováno v:
PLoS Genetics, Vol 19, Iss 7, p e1010793 (2023)
Mutations in subunits of the mitochondrial NADH dehydrogenase cause mitochondrial complex I deficiency, a group of severe neurological diseases that can result in death in infancy. The pathogenesis of complex I deficiency remain poorly understood, an
Externí odkaz:
https://doaj.org/article/720dde159eb94f2e9971e386d99fd3c0